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Items: 10


Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC.

Dinnen RD, Mao Y, Qiu W, Cassai N, Slavkovich VN, Nichols G, Su GH, Brandt-Rauf P, Fine RL.

Mol Cancer Ther. 2013 Dec;12(12):2792-803. doi: 10.1158/1535-7163.MCT-13-0234. Epub 2013 Oct 14.


Capecitabine and temozolomide (CAPTEM) for metastatic, well-differentiated neuroendocrine cancers: The Pancreas Center at Columbia University experience.

Fine RL, Gulati AP, Krantz BA, Moss RA, Schreibman S, Tsushima DA, Mowatt KB, Dinnen RD, Mao Y, Stevens PD, Schrope B, Allendorf J, Lee JA, Sherman WH, Chabot JA.

Cancer Chemother Pharmacol. 2013 Mar;71(3):663-70. doi: 10.1007/s00280-012-2055-z. Epub 2013 Jan 31.


The use of fluorescent probes in the study of reactive oxygen species in pancreatic cancer cells.

Dinnen RD, Mao Y, Fine RL.

Methods Mol Biol. 2013;980:321-9. doi: 10.1007/978-1-62703-287-2_18.


Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.

Wang X, Di Pasqua AJ, Govind S, McCracken E, Hong C, Mi L, Mao Y, Wu JY, Tomita Y, Woodrick JC, Fine RL, Chung FL.

J Med Chem. 2011 Feb 10;54(3):809-16. doi: 10.1021/jm101199t. Epub 2011 Jan 11.


Activation of targeted necrosis by a p53 peptide: a novel death pathway that circumvents apoptotic resistance.

Dinnen RD, Drew L, Petrylak DP, Mao Y, Cassai N, Szmulewicz J, Brandt-Rauf P, Fine RL.

J Biol Chem. 2007 Sep 14;282(37):26675-86. Epub 2007 Jul 18.


Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide.

Senatus PB, Li Y, Mandigo C, Nichols G, Moise G, Mao Y, Brown MD, Anderson RC, Parsa AT, Brandt-Rauf PW, Bruce JN, Fine RL.

Mol Cancer Ther. 2006 Jan;5(1):20-8.


The role of alpha-helical structure in p53 peptides as a determinant for their mechanism of cell death: necrosis versus apoptosis.

Rosal R, Brandt-Rauf P, Pincus MR, Wang H, Mao Y, Li Y, Fine RL.

Adv Drug Deliv Rev. 2005 Feb 28;57(4):653-60. Epub 2005 Jan 8. Review.


Selective induction of apoptosis through the FADD/caspase-8 pathway by a p53 c-terminal peptide in human pre-malignant and malignant cells.

Li Y, Mao Y, Rosal RV, Dinnen RD, Williams AC, Brandt-Rauf PW, Fine RL.

Int J Cancer. 2005 May 20;115(1):55-64.


Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143.

Li Y, Raffo AJ, Drew L, Mao Y, Tran A, Petrylak DP, Fine RL.

Cancer Res. 2003 Apr 1;63(7):1527-33.

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