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Items: 1 to 20 of 122


The functional switch of TGF-β signaling in breast cancer.

Shi Q, Chen YG.

Oncotarget. 2019 Feb 26;10(17):1604-1605. doi: 10.18632/oncotarget.26715. eCollection 2019 Feb 26. No abstract available.


ALK-mediated Tyr95 phosphorylation of Smad4 impairs its transcription activity and the tumor suppressive activity of TGF-β.

Shi Q, Chen YG.

Sci China Life Sci. 2019 Mar;62(3):431-432. doi: 10.1007/s11427-019-9506-x. Epub 2019 Feb 27. No abstract available.


2D- and 3D-Based Intestinal Stem Cell Cultures for Personalized Medicine.

Liu Y, Chen YG.

Cells. 2018 Nov 22;7(12). pii: E225. doi: 10.3390/cells7120225. Review.


Activin/Smad2 and Wnt/β-catenin up-regulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human embryonic stem cells.

Xu X, Wang L, Liu B, Xie W, Chen YG.

J Biol Chem. 2018 Nov 30;293(48):18444-18453. doi: 10.1074/jbc.RA118.003688. Epub 2018 Oct 3.


Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.

Ye P, Chiang YJ, Qi Z, Li Y, Wang S, Liu Y, Li X, Chen YG.

PLoS Genet. 2018 Sep 27;14(9):e1007697. doi: 10.1371/journal.pgen.1007697. eCollection 2018 Sep.


A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5+ intestinal stem cell maintenance.

Li Y, Liu Y, Liu B, Wang J, Wei S, Qi Z, Wang S, Fu W, Chen YG.

Cell Discov. 2018 Sep 4;4:49. doi: 10.1038/s41421-018-0051-0. eCollection 2018.


HER2/EGFR-AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer.

Huang F, Shi Q, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG.

Cancer Res. 2018 Nov 1;78(21):6073-6085. doi: 10.1158/0008-5472.CAN-18-0136. Epub 2018 Aug 31.


Monolayer culture of intestinal epithelium sustains Lgr5+ intestinal stem cells.

Liu Y, Qi Z, Li X, Du Y, Chen YG.

Cell Discov. 2018 Jun 12;4:32. doi: 10.1038/s41421-018-0036-z. eCollection 2018. No abstract available.


BMP signaling in homeostasis, transformation and inflammatory response of intestinal epithelium.

Wang S, Chen YG.

Sci China Life Sci. 2018 Jul;61(7):800-807. doi: 10.1007/s11427-018-9310-7. Epub 2018 May 29. Review.


Efficient Culture of Intestinal Organoids with Blebbistatin.

Qi Z, Chen YG.

Methods Mol Biol. 2017 Sep 27. doi: 10.1007/7651_2017_70. [Epub ahead of print]


Feedback regulation of TGF-β signaling.

Yan X, Xiong X, Chen YG.

Acta Biochim Biophys Sin (Shanghai). 2018 Jan 1;50(1):37-50. doi: 10.1093/abbs/gmx129. Review.


A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/β-catenin signalling pathway.

Wu Y, Li YH, Li X, Zou Y, Liao HL, Liu L, Chen YG, Bierer D, Hu HG.

Chem Sci. 2017 Nov 1;8(11):7368-7373. doi: 10.1039/c7sc02420g. Epub 2017 Aug 29.


Interplay between TGF-β signaling and receptor tyrosine kinases in tumor development.

Shi Q, Chen YG.

Sci China Life Sci. 2017 Oct;60(10):1133-1141. doi: 10.1007/s11427-017-9173-5. Epub 2017 Oct 23. Review.


TGFβ induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/β-catenin signaling.

Wang JL, Qi Z, Li YH, Zhao HM, Chen YG, Fu W.

Oncotarget. 2017 Jul 26;8(41):70214-70225. doi: 10.18632/oncotarget.19603. eCollection 2017 Sep 19.


CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis.

Yan X, Wu J, Jiang Q, Cheng H, Han JJ, Chen YG.

J Mol Cell Biol. 2018 Feb 1;10(1):48-59. doi: 10.1093/jmcb/mjx042.


Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling.

Yu Y, Gu S, Li W, Sun C, Chen F, Xiao M, Wang L, Xu D, Li Y, Ding C, Xia Z, Li Y, Ye S, Xu P, Zhao B, Qin J, Chen YG, Lin X, Feng XH.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10113-10118. doi: 10.1073/pnas.1705755114. Epub 2017 Sep 5.


AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation.

Lin H, Ying Y, Wang YY, Wang G, Jiang SS, Huang D, Luo L, Chen YG, Gerstenfeld LC, Luo Z.

Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2369-2377. doi: 10.1016/j.bbamcr.2017.08.009. Epub 2017 Aug 25.


Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK.

Ying Y, Ueta T, Jiang S, Lin H, Wang Y, Vavvas D, Wen R, Chen YG, Luo Z.

Oncotarget. 2017 May 16;8(20):32794-32806. doi: 10.18632/oncotarget.15825.


BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.

Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han JJ, Chen YG.

Nat Commun. 2017 Jan 6;8:13824. doi: 10.1038/ncomms13824.


Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells.

Wang L, Xu X, Cao Y, Li Z, Cheng H, Zhu G, Duan F, Na J, Han JJ, Chen YG.

J Biol Chem. 2017 Jan 27;292(4):1339-1350. doi: 10.1074/jbc.M116.766949. Epub 2016 Dec 13.

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