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Items: 1 to 20 of 32

1.

A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.

Zeng T, Zuo Z, Luo Y, Zhao Y, Yu Y, Chen Q.

FEBS Open Bio. 2019 May 13. doi: 10.1002/2211-5463.12658. [Epub ahead of print]

2.

In-situ biogas upgrading by a stepwise addition of ash additives: Methanogen adaption and CO2 sequestration.

Yin C, Shen Y, Yu Y, Yuan H, Lou Z, Zhu N.

Bioresour Technol. 2019 Jun;282:1-8. doi: 10.1016/j.biortech.2019.02.110. Epub 2019 Feb 25.

PMID:
30844515
3.

Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase.

Yang LL, Xu W, Yan J, Su HL, Yuan C, Li C, Zhang X, Yu ZJ, Yan YH, Yu Y, Chen Q, Wang Z, Li L, Qian S, Li GB.

Medchemcomm. 2018 Dec 7;10(1):164-168. doi: 10.1039/c8md00462e. eCollection 2019 Jan 1.

4.

Structural connectome alterations in patients with disorders of consciousness revealed by 7-tesla magnetic resonance imaging.

Tan X, Zhou Z, Gao J, Meng F, Yu Y, Zhang J, He F, Wei R, Wang J, Peng G, Zhang X, Pan G, Luo B.

Neuroimage Clin. 2019 Jan 29;22:101702. doi: 10.1016/j.nicl.2019.101702. [Epub ahead of print]

5.

Prenatal determinants of childhood obesity: a review of risk factors 1.

Liao XP, Yu Y, Marc I, Dubois L, Abdelouahab N, Bouchard L, Wu YT, Ouyang F, Huang HF, Fraser WD.

Can J Physiol Pharmacol. 2019 Mar;97(3):147-154. doi: 10.1139/cjpp-2018-0403. Epub 2019 Jan 19.

PMID:
30661367
6.

Discovery of a Prenylated Flavonol Derivative as a Pin1 Inhibitor to Suppress Hepatocellular Carcinoma by Modulating MicroRNA Biogenesis.

Zheng Y, Pu W, Li J, Shen X, Zhou Q, Fan X, Yang SY, Yu Y, Chen Q, Wang C, Wu X, Peng Y.

Chem Asian J. 2019 Jan 4;14(1):130-134. doi: 10.1002/asia.201801461. Epub 2018 Nov 26.

PMID:
30474357
7.

A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.

Ning N, Yu Y, Wu M, Zhang R, Zhang T, Zhu C, Huang L, Yun CH, Benes CH, Zhang J, Deng X, Chen Q, Ren R.

Cancer Res. 2018 Oct 15;78(20):5949-5957. doi: 10.1158/0008-5472.CAN-18-0455. Epub 2018 Aug 22.

PMID:
30135190
8.

Effects of theta burst stimulation of the left dorsolateral prefrontal cortex in disorders of consciousness.

Wu M, Wu Y, Yu Y, Gao J, Meng F, He F, Shi J, Luo B.

Brain Stimul. 2018 Nov - Dec;11(6):1382-1384. doi: 10.1016/j.brs.2018.07.055. Epub 2018 Aug 1. No abstract available.

PMID:
30120046
9.

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.

Yang LL, Wang HL, Zhong L, Yuan C, Liu SY, Yu ZJ, Liu S, Yan YH, Wu C, Wang Y, Wang Z, Yu Y, Chen Q, Li GB.

Eur J Med Chem. 2018 Jul 15;155:806-823. doi: 10.1016/j.ejmech.2018.06.041. Epub 2018 Jun 19.

PMID:
29957526
10.

SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines.

Yan W, Yang T, Yang J, Wang T, Yu Y, Wang Y, Chen Q, Bai P, Li D, Ye H, Qiu Q, Zhou Y, Hu Y, Yang S, Wei Y, Li W, Chen L.

Cell Physiol Biochem. 2018;47(2):489-504. doi: 10.1159/000489983. Epub 2018 May 22.

11.

The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin.

Yang J, Yan W, Yu Y, Wang Y, Yang T, Xue L, Yuan X, Long C, Liu Z, Chen X, Hu M, Zheng L, Qiu Q, Pei H, Li D, Wang F, Bai P, Wen J, Ye H, Chen L.

J Biol Chem. 2018 Jun 15;293(24):9461-9472. doi: 10.1074/jbc.RA117.001658. Epub 2018 Apr 24.

PMID:
29691282
12.

Preparation and anti-cancer evaluation of promiximab-MMAE, an anti-CD56 antibody drug conjugate, in small cell lung cancer cell line xenograft models.

Yu L, Yao Y, Wang Y, Zhou S, Lai Q, Lu Y, Liu Y, Zhang R, Wang R, Liu C, Gou L, Chen X, Yu Y, Chen Q, Yang J.

J Drug Target. 2018 Dec;26(10):905-912. doi: 10.1080/1061186X.2018.1450413. Epub 2018 Apr 13.

PMID:
29630426
13.

Multifunctional Roles of the Ventral Stream in Language Models: Advanced Segmental Quantification in Post-Stroke Aphasic Patients.

Zhang J, Wei X, Xie S, Zhou Z, Shang D, Ji R, Yu Y, He F, Du Y, Ye X, Luo B.

Front Neurol. 2018 Feb 27;9:89. doi: 10.3389/fneur.2018.00089. eCollection 2018.

14.

((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.

Liu S, Jing L, Yu ZJ, Wu C, Zheng Y, Zhang E, Chen Q, Yu Y, Guo L, Wu Y, Li GB.

Eur J Med Chem. 2018 Feb 10;145:649-660. doi: 10.1016/j.ejmech.2018.01.032. Epub 2018 Jan 11.

PMID:
29353720
15.

Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design.

Cheng J, Wu Y, Wang Y, Wang C, Wang Y, Wu C, Zeng S, Yu Y, Chen Q.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):185-188. doi: 10.1016/j.bbrc.2017.10.104. Epub 2017 Nov 2.

PMID:
29102632
16.

Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design.

Niu L, Wang Y, Wang C, Wang Y, Jiang X, Ma L, Wu C, Yu Y, Chen Q.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):718-722. doi: 10.1016/j.bbrc.2017.08.125. Epub 2017 Aug 30.

PMID:
28864414
17.

Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

Liu S, Ji S, Yu ZJ, Wang HL, Cheng X, Li WJ, Jing L, Yu Y, Chen Q, Yang LL, Li GB, Wu Y.

Chem Biol Drug Des. 2018 Jan;91(1):257-268. doi: 10.1111/cbdd.13077. Epub 2017 Aug 18.

PMID:
28756638
18.

Mechanism of microtubule stabilization by taccalonolide AJ.

Wang Y, Yu Y, Li GB, Li SA, Wu C, Gigant B, Qin W, Chen H, Wu Y, Chen Q, Yang J.

Nat Commun. 2017 Jun 6;8:15787. doi: 10.1038/ncomms15787.

19.

Hypertension and breast cancer risk: a systematic review and meta-analysis.

Han H, Guo W, Shi W, Yu Y, Zhang Y, Ye X, He J.

Sci Rep. 2017 Mar 20;7:44877. doi: 10.1038/srep44877. Review.

20.

PGRMC1 Is a Novel Potential Tumor Biomarker of Human Renal Cell Carcinoma Based on Quantitative Proteomic and Integrative Biological Assessments.

Zhang D, Xia X, Wang X, Zhang P, Lu W, Yu Y, Deng S, Yang H, Zhu H, Xu N, Liang S.

PLoS One. 2017 Jan 20;12(1):e0170453. doi: 10.1371/journal.pone.0170453. eCollection 2017.

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