Format

Send to

Choose Destination
Mar Drugs. 2016 Dec 20;14(12). pii: E233. doi: 10.3390/md14120233.

Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum.

Author information

1
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. zhihanzhang1992@163.com.
2
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. mixmix@stu.scau.edu.cn.
3
Pharmaceutical Research Center, School of Pharmacology, Guangzhou Medical University, Guangzhou 510182, China. huangjunjun1985@sina.com.
4
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. sloe96824400@126.com.
5
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. wuyuehua_10@163.com.
6
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. m18320728922@163.com.
7
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. ydeng@scau.edu.cn.
8
Guangdong Innovative and Entrepreneurial Research Team of Sociomicrobiology Basic Science and Frontier Technology, South China Agricultural University, Guangzhou 510642, China. ydeng@scau.edu.cn.
9
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. zdjiang@scau.edu.cn.
10
State Key Laboratory Breeding Base of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, Key Laboratory of Marine Genetic Resources of Fujian Province, Xiamen 361005, China. shaozz@163.com.
11
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. lhzhang01@scau.edu.cn.
12
Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. hefei@scsio.ac.cn.

Abstract

Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (3-9), were isolated from the deep-sea-derived fungus Chaetomium globosum. The structures of new compounds 1 and 2 were elucidated by extensive 1D and 2D NMR and mass spectroscopic data. All the compounds were evaluated for their antiproliferative activities against MDA-MB-231 human breast cancer cells, LNCaP human prostate cancer cells, and B16F10 mouse melanoma cells. Compound 6 showed significant antiproliferative activity against LNCaP and B16F10 cell lines with IC50 values of 0.62 and 2.78 μM, respectively. Further testing confirmed that compound 6 inhibited the growth of LNCaP cells by inducing apoptosis.

KEYWORDS:

antiproliferative activity; cytochalasans; fungus

PMID:
27999388
PMCID:
PMC5192470
DOI:
10.3390/md14120233
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center