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Items: 1 to 20 of 33

1.

An effective antidotal combination of polymyxin B and methylprednisolone for α-amanitin intoxication.

Garcia J, Costa VM, Bovolini A, Duarte JA, Rodrigues DF, de Lourdes Bastos M, Carvalho F.

Arch Toxicol. 2019 Mar 19. doi: 10.1007/s00204-019-02426-5. [Epub ahead of print]

PMID:
30891624
2.

The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells.

Reis-Mendes A, Carvalho F, Remião F, Sousa E, Bastos ML, Costa VM.

Biomolecules. 2019 Mar 11;9(3). pii: E98. doi: 10.3390/biom9030098.

3.

Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells.

Pereira-Oliveira M, Reis-Mendes A, Carvalho F, Remião F, Bastos ML, Costa VM.

Biomolecules. 2019 Jan 10;9(1). pii: E21. doi: 10.3390/biom9010021.

4.

Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells.

Reis-Mendes A, Alves M, Carvalho F, Remião F, Bastos ML, Costa VM.

Interdiscip Toxicol. 2018 May;11(1):13-21. doi: 10.2478/intox-2018-0002. Epub 2018 Aug 6.

5.

Mitoxantrone is More Toxic than Doxorubicin in SH-SY5Y Human Cells: A 'Chemobrain' In Vitro Study.

Almeida D, Pinho R, Correia V, Soares J, Bastos ML, Carvalho F, Capela JP, Costa VM.

Pharmaceuticals (Basel). 2018 May 5;11(2). pii: E41. doi: 10.3390/ph11020041.

6.

Methylphenidate clinically oral doses improved brain and heart glutathione redox status and evoked renal and cardiac tissue injury in rats.

Loureiro-Vieira S, Costa VM, Duarte JA, Duarte-Araújo M, Gonçalves-Monteiro S, Maria de Lourdes B, Carvalho F, Capela JP.

Biomed Pharmacother. 2018 Apr;100:551-563. doi: 10.1016/j.biopha.2018.02.017. Epub 2018 Feb 23.

PMID:
29482048
7.

Comprehensive review of cardiovascular toxicity of drugs and related agents.

Mladěnka P, Applová L, Patočka J, Costa VM, Remiao F, Pourová J, Mladěnka A, Karlíčková J, Jahodář L, Vopršalová M, Varner KJ, Štěrba M; TOX-OER and CARDIOTOX Hradec Králové Researchers and Collaborators.

Med Res Rev. 2018 Jul;38(4):1332-1403. doi: 10.1002/med.21476. Epub 2018 Jan 5. Review.

8.

Methylphenidate effects in the young brain: friend or foe?

Loureiro-Vieira S, Costa VM, de Lourdes Bastos M, Carvalho F, Capela JP.

Int J Dev Neurosci. 2017 Aug;60:34-47. doi: 10.1016/j.ijdevneu.2017.04.002. Epub 2017 Apr 13. Review.

PMID:
28412445
9.

The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs.

Hrynchak I, Sousa E, Pinto M, Costa VM.

Drug Metab Rev. 2017 May;49(2):158-196. doi: 10.1080/03602532.2017.1316285. Epub 2017 Apr 25. Review.

PMID:
28393622
10.

Quantitative histochemistry for macrophage biodistribution on mice liver and spleen after the administration of a pharmacological-relevant dose of polyacrylic acid-coated iron oxide nanoparticles.

Rodrigues D, Freitas M, Marisa Costa V, Arturo Lopez-Quintela M, Rivas J, Freitas P, Carvalho F, Fernandes E, Silva P.

Nanotoxicology. 2017 Mar;11(2):256-266. doi: 10.1080/17435390.2017.1291865. Epub 2017 Feb 23.

PMID:
28166432
11.

Chemical characterization and protective effect of the Bactris setosa Mart. fruit against oxidative/nitrosative stress.

Boeing JS, Ribeiro D, Chisté RC, Visentainer JV, Costa VM, Freitas M, Fernandes E.

Food Chem. 2017 Apr 1;220:427-437. doi: 10.1016/j.foodchem.2016.09.188. Epub 2016 Sep 30.

PMID:
27855922
12.

"Ecstasy" toxicity to adolescent rats following an acute low binge dose.

Teixeira-Gomes A, Costa VM, Feio-Azevedo R, Duarte JA, Duarte-Araújo M, Fernandes E, Bastos Mde L, Carvalho F, Capela JP.

BMC Pharmacol Toxicol. 2016 Jun 28;17(1):28. doi: 10.1186/s40360-016-0070-0.

13.

Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity.

Couto D, Freitas M, Costa VM, Chisté RC, Almeida A, Lopez-Quintela MA, Rivas J, Freitas P, Silva P, Carvalho F, Fernandes E.

J Appl Toxicol. 2016 Oct;36(10):1321-31. doi: 10.1002/jat.3323. Epub 2016 Apr 22.

PMID:
27102234
14.

The Role of the Metabolism of Anticancer Drugs in Their Induced-Cardiotoxicity.

Reis-Mendes AF, Sousa E, de Lourdes Bastos M, Costa VM.

Curr Drug Metab. 2015;17(1):75-90.

PMID:
26526839
15.

A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B.

Garcia J, Costa VM, Carvalho AT, Silvestre R, Duarte JA, Dourado DF, Arbo MD, Baltazar T, Dinis-Oliveira RJ, Baptista P, de Lourdes Bastos M, Carvalho F.

Arch Toxicol. 2015 Dec;89(12):2305-23. doi: 10.1007/s00204-015-1582-x. Epub 2015 Sep 18.

PMID:
26385100
16.

The age factor for mitoxantrone's cardiotoxicity: multiple doses render the adult mouse heart more susceptible to injury.

Dores-Sousa JL, Duarte JA, Seabra V, Bastos Mde L, Carvalho F, Costa VM.

Toxicology. 2015 Mar 2;329:106-19. doi: 10.1016/j.tox.2015.01.006. Epub 2015 Jan 9.

PMID:
25582955
17.

The neurotoxicity of amphetamines during the adolescent period.

Teixeira-Gomes A, Costa VM, Feio-Azevedo R, Bastos Mde L, Carvalho F, Capela JP.

Int J Dev Neurosci. 2015 Apr;41:44-62. doi: 10.1016/j.ijdevneu.2014.12.001. Epub 2014 Dec 4. Review.

PMID:
25482046
18.

Inosine strongly enhances proliferation of human C32 melanoma cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K pathways.

Soares AS, Costa VM, Diniz C, Fresco P.

Basic Clin Pharmacol Toxicol. 2015 Jan;116(1):25-36. doi: 10.1111/bcpt.12280. Epub 2014 Jul 19.

19.

Mitochondrial cumulative damage induced by mitoxantrone: late onset cardiac energetic impairment.

Rossato LG, Costa VM, Dallegrave E, Arbo M, Silva R, Ferreira R, Amado F, Dinis-Oliveira RJ, Duarte JA, de Lourdes Bastos M, Palmeira C, Remião F.

Cardiovasc Toxicol. 2014 Mar;14(1):30-40. doi: 10.1007/s12012-013-9230-2.

PMID:
24096626
20.

Therapeutic concentrations of mitoxantrone elicit energetic imbalance in H9c2 cells as an earlier event.

Rossato LG, Costa VM, Vilas-Boas V, de Lourdes Bastos M, Rolo A, Palmeira C, Remião F.

Cardiovasc Toxicol. 2013 Dec;13(4):413-25. doi: 10.1007/s12012-013-9224-0.

PMID:
24046265

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