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Items: 1 to 20 of 24

1.

In Silico and in Vitro Assessment of OATP1B1 Inhibition in Drug Discovery.

Danielson ML, Sawada GA, Raub TJ, Desai PV.

Mol Pharm. 2018 Aug 6;15(8):3060-3068. doi: 10.1021/acs.molpharmaceut.8b00168. Epub 2018 Jul 5.

PMID:
29927611
2.

QSAR Model of Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain: Incorporating P-glycoprotein Efflux as a Variable.

Dolgikh E, Watson IA, Desai PV, Sawada GA, Morton S, Jones TM, Raub TJ.

J Chem Inf Model. 2016 Nov 28;56(11):2225-2233. Epub 2016 Oct 13.

PMID:
27684523
3.

A Tribute to Ronald T. Borchardt--Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man.

Schowen KB, Schowen RL, Borchardt SE, Borchardt PM, Artursson P, Audus KL, Augustijns P, Nicolazzo JA, Raub TJ, Schöneich C, Siahaan TJ, Takakura Y, Thakker DR, Wolfe MS.

J Pharm Sci. 2016 Feb;105(2):370-385. doi: 10.1002/jps.24687. Epub 2016 Jan 29. No abstract available.

PMID:
26453244
4.

Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft.

Raub TJ, Wishart GN, Kulanthaivel P, Staton BA, Ajamie RT, Sawada GA, Gelbert LM, Shannon HE, Sanchez-Martinez C, De Dios A.

Drug Metab Dispos. 2015 Sep;43(9):1360-71. doi: 10.1124/dmd.114.062745. Epub 2015 Jul 6.

PMID:
26149830
5.

Efficiency gains in tracer identification for nuclear imaging: can in vivo LC-MS/MS evaluation of small molecules screen for successful PET tracers?

Joshi EM, Need A, Schaus J, Chen Z, Benesh D, Mitch C, Morton S, Raub TJ, Phebus L, Barth V.

ACS Chem Neurosci. 2014 Dec 17;5(12):1154-63. doi: 10.1021/cn500073j. Epub 2014 Oct 13. Review.

PMID:
25247893
6.

Integration of in silico and in vitro tools for scaffold optimization during drug discovery: predicting P-glycoprotein efflux.

Desai PV, Sawada GA, Watson IA, Raub TJ.

Mol Pharm. 2013 Apr 1;10(4):1249-61. doi: 10.1021/mp300555n. Epub 2013 Mar 1.

PMID:
23363443
7.

How hydrogen bonds impact P-glycoprotein transport and permeability.

Desai PV, Raub TJ, Blanco MJ.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6540-8. doi: 10.1016/j.bmcl.2012.08.059. Epub 2012 Aug 23. Review.

8.

What is your diagnosis? Serum biochemical data from genetically modified mice.

Irizarry Rovira AR, Gao H, Jolly RA, Raub TJ.

Vet Clin Pathol. 2012 Jun;41(2):301-2. doi: 10.1111/j.1939-165X.2012.00428.x. Epub 2012 May 2. No abstract available.

PMID:
22551217
9.

How well do lipophilicity parameters, MEEKC microemulsion capacity factor, and plasma protein binding predict CNS tissue binding?

Zamek-Gliszczynski MJ, Sprague KE, Espada A, Raub TJ, Morton SM, Manro JR, Molina-Martin M.

J Pharm Sci. 2012 May;101(5):1932-40. doi: 10.1002/jps.23081. Epub 2012 Feb 17.

PMID:
22344827
10.

Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver.

Lee JK, Abe K, Bridges AS, Patel NJ, Raub TJ, Pollack GM, Brouwer KL.

Drug Metab Dispos. 2009 Sep;37(9):1916-21. doi: 10.1124/dmd.109.026815. Epub 2009 Jun 1.

11.

Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity.

Gannon MK 2nd, Holt JJ, Bennett SM, Wetzel BR, Loo TW, Bartlett MC, Clarke DM, Sawada GA, Higgins JW, Tombline G, Raub TJ, Detty MR.

J Med Chem. 2009 May 28;52(10):3328-41. doi: 10.1021/jm900253g.

12.

Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier.

Zhao R, Raub TJ, Sawada GA, Kasper SC, Bacon JA, Bridges AS, Pollack GM.

Drug Metab Dispos. 2009 Jun;37(6):1251-8. doi: 10.1124/dmd.108.025064. Epub 2009 Mar 9.

13.

Simple integrated single-atom detector.

Wilzbach M, Heine D, Groth S, Liu X, Raub T, Hessmo B, Schmiedmayer J.

Opt Lett. 2009 Feb 1;34(3):259-61.

PMID:
19183624
14.

Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells.

Sawada GA, Raub TJ, William Higgins J, Brennan NK, Moore TM, Tombline G, Detty MR.

Bioorg Med Chem. 2008 Nov 15;16(22):9745-56. doi: 10.1016/j.bmc.2008.09.065. Epub 2008 Sep 30.

PMID:
18849167
15.

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.

Acker BA, Jacobsen EJ, Rogers BN, Wishka DG, Reitz SC, Piotrowski DW, Myers JK, Wolfe ML, Groppi VE, Thornburgh BA, Tinholt PM, Walters RR, Olson BA, Fitzgerald L, Staton BA, Raub TJ, Krause M, Li KS, Hoffmann WE, Hajos M, Hurst RS, Walker DP.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3611-5. doi: 10.1016/j.bmcl.2008.04.070. Epub 2008 May 1.

PMID:
18490160
16.

ATP occlusion by P-glycoprotein as a surrogate measure for drug coupling.

Tombline G, Holt JJ, Gannon MK, Donnelly DJ, Wetzel B, Sawada GA, Raub TJ, Detty MR.

Biochemistry. 2008 Mar 11;47(10):3294-307. doi: 10.1021/bi7021393. Epub 2008 Feb 15.

PMID:
18275155
17.

Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice.

Tian X, Zamek-Gliszczynski MJ, Li J, Bridges AS, Nezasa K, Patel NJ, Raub TJ, Brouwer KL.

Drug Metab Dispos. 2008 Jan;36(1):61-4. Epub 2007 Oct 3.

18.

Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.

Tian X, Li J, Zamek-Gliszczynski MJ, Bridges AS, Zhang P, Patel NJ, Raub TJ, Pollack GM, Brouwer KL.

Antimicrob Agents Chemother. 2007 Sep;51(9):3230-4. Epub 2007 Jun 18.

19.

Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists.

Walker DP, Wishka DG, Piotrowski DW, Jia S, Reitz SC, Yates KM, Myers JK, Vetman TN, Margolis BJ, Jacobsen EJ, Acker BA, Groppi VE, Wolfe ML, Thornburgh BA, Tinholt PM, Cortes-Burgos LA, Walters RR, Hester MR, Seest EP, Dolak LA, Han F, Olson BA, Fitzgerald L, Staton BA, Raub TJ, Hajos M, Hoffmann WE, Li KS, Higdon NR, Wall TM, Hurst RS, Wong EH, Rogers BN.

Bioorg Med Chem. 2006 Dec 15;14(24):8219-48. Epub 2006 Oct 2.

PMID:
17011782
20.

The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice.

Zamek-Gliszczynski MJ, Nezasa K, Tian X, Kalvass JC, Patel NJ, Raub TJ, Brouwer KL.

Mol Pharmacol. 2006 Dec;70(6):2127-33. Epub 2006 Sep 7.

PMID:
16959944

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