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Nutrients. 2019 Jan 6;11(1). pii: E104. doi: 10.3390/nu11010104.

Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol.

Author information

1
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8572, Japan. eri.k@dc.tohoku.ac.jp.
2
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8572, Japan. junyai@tohoku.ac.jp.
3
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8572, Japan. nshimizu@dc.tohoku.ac.jp.
4
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8572, Japan. t.koku@dc.tohoku.ac.jp.
5
Department of Cell Biology, Division of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan. tyunkato@gmail.com.
6
Tsuno Food Industrial CO., LTD., Ito-Gun, Wakayama 649-7194, Japan. sawada.kazue@tsuno.co.jp.
7
Tsuno Food Industrial CO., LTD., Ito-Gun, Wakayama 649-7194, Japan. hirohas@tsuno.co.jp.
8
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8572, Japan. takahiro.eitsuka.a1@tohoku.ac.jp.
9
Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai, Miyagi 980-8579, Japan. miyazawa@m.tohoku.ac.jp.
10
Food and Health Science Research Unit, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8572, Japan. miyazawa@m.tohoku.ac.jp.
11
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8572, Japan. nkgw@m.tohoku.ac.jp.

Abstract

γ-Oryzanol (OZ), abundant in rice bran oil, has gained attention due to its physiological activities (e.g., lipid-lowering effects). However, the absorption and metabolism of orally ingested OZ have not yet been fully elucidated. In this study, diets containing normal or high contents of OZ were fed to obesity model mice for 8 weeks, and OZ concentrations in plasma and organs were analyzed by HPLC-MS/MS. To evaluate the relationship between OZ accumulation and lipid metabolism in vivo, lipid concentrations in the mice plasma and liver were also measured. As a result, the accumulation of intact OZ in plasma and organs was seen in mice fed diets containing OZ, where mice fed diets containing higher OZ contents demonstrated higher levels of OZ accumulation and lower amounts of plasma lipids. These results, in combination with our additional data from a single oral administration test, suggest the possibility that intact OZ, along with its metabolites (e.g., ferulic acid), is biologically-active.

KEYWORDS:

HPLC-MS/MS; absorption and metabolism; rice bran oil; γ-oryzanol

PMID:
30621350
PMCID:
PMC6356301
DOI:
10.3390/nu11010104
[Indexed for MEDLINE]
Free PMC Article

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