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Mar Drugs. 2018 Oct 25;16(11). pii: E404. doi: 10.3390/md16110404.

Components from the Leaves and Twigs of Mangrove Lumnitzera racemosa with Anti-Angiogenic and Anti-Inflammatory Effects.

Yu SY1, Wang SW2,3, Hwang TL4,5,6, Wei BL7, Su CJ8, Chang FR9,10, Cheng YB11,12.

Author information

1
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. s91412232@gmail.com.
2
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. shihwei@mmc.edu.tw.
3
Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan. shihwei@mmc.edu.tw.
4
Graduate Institute of Natural Products, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
5
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
6
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
7
Department of Life Science, National Taitung University, Taitung 950, Taiwan. blwei@nttu.edu.tw.
8
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. scj820826@gmail.com.
9
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.
10
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan. aaronfrc@kmu.edu.tw.
11
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. jmb@kmu.edu.tw.
12
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. jmb@kmu.edu.tw.

Abstract

One new neolignan, racelactone A (1), together with seven known compounds (2-8) were isolated from the methanolic extract of the leaves and twigs of Lumnitzera racemosa. The structure of racelactone A (1) was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation. Furthermore, compounds 1, 4, and 5 showed significant anti-inflammatory effects with IC50 values of 4.95 ± 0.89, 1.95 ± 0.40, and 2.57 ± 0.23 μM, respectively. The plausible biosynthesis pathway of racelactone A (1) was proposed.

KEYWORDS:

Lumnitzera racemosa; anti-angiogenesis; anti-inflammation; neolignan

PMID:
30366373
PMCID:
PMC6267291
DOI:
10.3390/md16110404
[Indexed for MEDLINE]
Free PMC Article

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