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Items: 1 to 20 of 90

1.

Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry.

Santos-Ferreira T, Herbig M, Otto O, Carido M, Karl MO, Michalakis S, Guck J, Ader M.

Cytometry A. 2019 May 20. doi: 10.1002/cyto.a.23798. [Epub ahead of print]

PMID:
31107590
2.

Safety and toxicology of ocular gene therapy with recombinant AAV Vector rAAV.hCNGA3 in non-human primates.

Peters T, Seitz IP, Michalakis S, Biel M, Wilhelm B, Reichel FF, Ochakovski GA, Zrenner E, Ueffing M, Korbmacher B, Korte S, Bartz-Schmidt KU, Fischer MD, Rd-Cure C.

Hum Gene Ther Clin Dev. 2019 Mar 13. doi: 10.1089/humc.2018.188. [Epub ahead of print]

PMID:
30864850
3.

Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis.

Borland K, Diesend J, Ito-Kureha T, Heissmeyer V, Hammann C, Buck AH, Michalakis S, Kellner S.

Genes (Basel). 2019 Jan 5;10(1). pii: E26. doi: 10.3390/genes10010026.

4.

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy.

Burkard M, Kohl S, Krätzig T, Tanimoto N, Brennenstuhl C, Bausch AE, Junger K, Reuter P, Sothilingam V, Beck SC, Huber G, Ding XQ, Mayer AK, Baumann B, Weisschuh N, Zobor D, Hahn GA, Kellner U, Venturelli S, Becirovic E, Charbel Issa P, Koenekoop RK, Rudolph G, Heckenlively J, Sieving P, Weleber RG, Hamel C, Zong X, Biel M, Lukowski R, Seeliger MW, Michalakis S, Wissinger B, Ruth P.

J Clin Invest. 2018 Dec 3;128(12):5663-5675. doi: 10.1172/JCI96098. Epub 2018 Nov 12.

5.

Optimized Subretinal Injection Technique for Gene Therapy Approaches.

Mühlfriedel R, Michalakis S, Garrido MG, Sothilingam V, Schön C, Biel M, Seeliger MW.

Methods Mol Biol. 2019;1834:405-412. doi: 10.1007/978-1-4939-8669-9_26.

PMID:
30324458
6.

In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy.

Wagner JE, Schön C, Becirovic E, Biel M, Michalakis S.

Methods Mol Biol. 2019;1834:383-390. doi: 10.1007/978-1-4939-8669-9_24.

PMID:
30324456
7.

Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial.

Kahle NA, Peters T, Zobor D, Kuehlewein L, Kohl S, Zhour A, Werner A, Seitz IP, Sothilingam V, Michalakis S, Biel M, Ueffing M, Zrenner E, Bartz-Schmidt KU, Fischer MD, Wilhelm BJC.

Hum Gene Ther Clin Dev. 2018 Sep;29(3):121-131. doi: 10.1089/humc.2018.088.

PMID:
30187779
8.

Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis.

Falk N, Kessler K, Schramm SF, Boldt K, Becirovic E, Michalakis S, Regus-Leidig H, Noegel AA, Ueffing M, Thiel CT, Roepman R, Brandstätter JH, Gießl A.

J Cell Sci. 2018 Aug 17;131(16). pii: jcs218487. doi: 10.1242/jcs.218487.

9.

Optogenetic Control of Neural Circuits in the Mongolian Gerbil.

Keplinger S, Beiderbeck B, Michalakis S, Biel M, Grothe B, Kunz L.

Front Cell Neurosci. 2018 Apr 24;12:111. doi: 10.3389/fncel.2018.00111. eCollection 2018.

10.

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients.

Reichel FF, Peters T, Wilhelm B, Biel M, Ueffing M, Wissinger B, Bartz-Schmidt KU, Klein R, Michalakis S, Fischer MD; RD-CURE Consortium.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1910-1915. doi: 10.1167/iovs.17-22494.

PMID:
29677353
11.

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress.

Barben M, Ail D, Storti F, Klee K, Schori C, Samardzija M, Michalakis S, Biel M, Meneau I, Blaser F, Barthelmes D, Grimm C.

Cell Death Differ. 2018 Dec;25(12):2071-2085. doi: 10.1038/s41418-018-0094-7. Epub 2018 Apr 17.

12.

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.

Michalakis S, Becirovic E, Biel M.

Int J Mol Sci. 2018 Mar 7;19(3). pii: E749. doi: 10.3390/ijms19030749. Review.

13.

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.

Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C.

Front Mol Neurosci. 2018 Jan 9;10:436. doi: 10.3389/fnmol.2017.00436. eCollection 2017.

14.

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.

Blank T, Goldmann T, Koch M, Amann L, Schön C, Bonin M, Pang S, Prinz M, Burnet M, Wagner JE, Biel M, Michalakis S.

Front Immunol. 2018 Jan 5;8:1930. doi: 10.3389/fimmu.2017.01930. eCollection 2017.

15.

Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

Schön C, Sothilingam V, Mühlfriedel R, Garcia Garrido M, Beck SC, Tanimoto N, Wissinger B, Paquet-Durand F, Biel M, Michalakis S, Seeliger MW, Consortium RC.

Hum Gene Ther. 2017 Dec 7. doi: 10.1089/hum.2017.156. [Epub ahead of print]

PMID:
29212391
16.

Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa.

Occelli LM, Schön C, Seeliger MW, Biel M, Michalakis S, Petersen-Jones S, Consortium RC.

Hum Gene Ther. 2017 Dec 6. doi: 10.1089/hum.2017.155. [Epub ahead of print]

PMID:
29212382
17.

Patients and animal models of CNGβ1-deficient retinitis pigmentosa support gene augmentation approach.

Petersen-Jones SM, Occelli LM, Winkler PA, Lee W, Sparrow JR, Tsukikawa M, Boye SL, Chiodo V, Capasso JE, Becirovic E, Schön C, Seeliger MW, Levin AV, Michalakis S, Hauswirth WW, Tsang SH.

J Clin Invest. 2018 Jan 2;128(1):190-206. doi: 10.1172/JCI95161. Epub 2017 Nov 20.

18.

Design and Development of AAV-based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa.

Schön C, Becirovic E, Biel M, Michalakis S.

Methods Mol Biol. 2018;1715:33-46. doi: 10.1007/978-1-4939-7522-8_3.

PMID:
29188504
19.

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates.

Seitz IP, Michalakis S, Wilhelm B, Reichel FF, Ochakovski GA, Zrenner E, Ueffing M, Biel M, Wissinger B, Bartz-Schmidt KU, Peters T, Fischer MD; RD-CURE Consortium.

Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5792-5801. doi: 10.1167/iovs.17-22473.

PMID:
29117317
20.

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

Reichel FF, Dauletbekov DL, Klein R, Peters T, Ochakovski GA, Seitz IP, Wilhelm B, Ueffing M, Biel M, Wissinger B, Michalakis S, Bartz-Schmidt KU, Fischer MD; RD-CURE Consortium.

Mol Ther. 2017 Dec 6;25(12):2648-2660. doi: 10.1016/j.ymthe.2017.08.018. Epub 2017 Aug 31.

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