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Items: 1 to 20 of 133


Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome.

Shilo A, Tosto FA, Rausch JW, Le Grice SFJ, Misteli T.

Nucleic Acids Res. 2019 Apr 22. pii: gkz259. doi: 10.1093/nar/gkz259. [Epub ahead of print]


Molecular recognition of a branched peptide with HIV-1 Rev Response Element (RRE) RNA.

Dai Y, Peralta AN, Wynn JE, Sherpa C, Li H, Verma A, Le Grice SFJ, Santos WL.

Bioorg Med Chem. 2019 Apr 15;27(8):1759-1765. doi: 10.1016/j.bmc.2019.03.016. Epub 2019 Mar 7.


Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time.

Sherpa C, Jackson PEH, Gray LR, Anastos K, Le Grice SFJ, Hammarskjold ML, Rekosh D.

J Virol. 2019 May 15;93(11). pii: e02102-18. doi: 10.1128/JVI.02102-18. Print 2019 Jun 1.


Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1.

Abulwerdi FA, Xu W, Ageeli AA, Yonkunas MJ, Arun G, Nam H, Schneekloth JS Jr, Dayie TK, Spector D, Baird N, Le Grice SFJ.

ACS Chem Biol. 2019 Feb 15;14(2):223-235. doi: 10.1021/acschembio.8b00807. Epub 2019 Jan 31.


Polymorphisms in KSHV-encoded microRNA sequences affect levels of mature viral microRNA in Kaposi Sarcoma lesions.

Marshall VA, Labo N, Sztuba-Solinska J, Cornejo Castro EM, Aleman K, Wyvill KM, McNamara L, Le Grice SFJ, Yarchoan R, Uldrick TS, MacPhail P, Polizzotto MN, Whitby D.

Oncotarget. 2018 Nov 9;9(88):35856-35869. doi: 10.18632/oncotarget.26321. eCollection 2018 Nov 9.


APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R.

Okamoto K, Rausch JW, Wakashin H, Fu Y, Chung JY, Dummer PD, Shin MK, Chandra P, Suzuki K, Shrivastav S, Rosenberg AZ, Hewitt SM, Ray PE, Noiri E, Le Grice SFJ, Hoek M, Han Z, Winkler CA, Kopp JB.

Commun Biol. 2018 Nov 7;1:188. doi: 10.1038/s42003-018-0188-2. eCollection 2018.


Sensitivity of the C-Terminal Nuclease Domain of Kaposi's Sarcoma-Associated Herpesvirus ORF29 to Two Classes of Active-Site Ligands.

Miller JT, Zhao H, Masaoka T, Varnado B, Cornejo Castro EM, Marshall VA, Kouhestani K, Lynn AY, Aron KE, Xia A, Beutler JA, Hirsch DR, Tang L, Whitby D, Murelli RP, Le Grice SFJ.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00233-18. doi: 10.1128/AAC.00233-18. Print 2018 Oct.


Broad anti-herpesviral activity of α-hydroxytropolones.

Dehghanpir SD, Birkenheuer CH, Yang K, Murelli RP, Morrison LA, Le Grice SFJ, Baines JD.

Vet Microbiol. 2018 Feb;214:125-131. doi: 10.1016/j.vetmic.2017.12.016. Epub 2017 Dec 27.


Probing the Structures of Viral RNA Regulatory Elements with SHAPE and Related Methodologies.

Rausch JW, Sztuba-Solinska J, Le Grice SFJ.

Front Microbiol. 2018 Jan 9;8:2634. doi: 10.3389/fmicb.2017.02634. eCollection 2017. Review.


The "Topological Train Ride" of a viral long non-coding RNA.

Sztuba-Solinska J, Le Grice SFJ.

RNA Biol. 2018 Jan 2;15(1):13-16. doi: 10.1080/15476286.2017.1391442. Epub 2017 Dec 7.


The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.

Grady LM, Szczepaniak R, Murelli RP, Masaoka T, Le Grice SFJ, Wright DL, Weller SK.

J Virol. 2017 Nov 14;91(23). pii: e01380-17. doi: 10.1128/JVI.01380-17. Print 2017 Dec 1.


Combining asymmetric 13C-labeling and isotopic filter/edit NOESY: a novel strategy for rapid and logical RNA resonance assignment.

LeBlanc RM, Longhini AP, Le Grice SFJ, Johnson BA, Dayie TK.

Nucleic Acids Res. 2017 Sep 19;45(16):e146. doi: 10.1093/nar/gkx591.


Recent Advances in Targeting the HIV-1 Tat/TAR Complex.

Abulwerdi FA, Le Grice SFJ.

Curr Pharm Des. 2017;23(28):4112-4121. doi: 10.2174/1381612823666170616081736. Review.


Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA: a structural scaffold for nuclear, cytoplasmic and viral proteins.

Sztuba-Solinska J, Rausch JW, Smith R, Miller JT, Whitby D, Le Grice SFJ.

Nucleic Acids Res. 2017 Jun 20;45(11):6805-6821. doi: 10.1093/nar/gkx241.


Reverse Transcription in the Saccharomyces cerevisiae Long-Terminal Repeat Retrotransposon Ty3.

Rausch JW, Miller JT, Le Grice SF.

Viruses. 2017 Mar 15;9(3). pii: E44. doi: 10.3390/v9030044. Review.


Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity.

Murelli RP, D'Erasmo MP, Hirsch DR, Meck C, Masaoka T, Wilson JA, Zhang B, Pal RK, Gallicchio E, Beutler JA, Le Grice SF.

Medchemcomm. 2016 Sep 1;7(9):1783-1788. doi: 10.1039/C6MD00238B. Epub 2016 Jul 7.


Traceless Solid-Phase α-Hydroxytropolone Synthesis.

D'Erasmo MP, Masaoka T, Wilson JA, Hunte EM Jr, Beutler JA, Le Grice SF, Murelli RP.

Medchemcomm. 2016 Sep 1;7(9):1789-1792. doi: 10.1039/C6MD00237D. Epub 2016 Jul 7.


Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA.

Abulwerdi FA, Shortridge MD, Sztuba-Solinska J, Wilson R, Le Grice SF, Varani G, Schneekloth JS Jr.

J Med Chem. 2016 Dec 22;59(24):11148-11160. doi: 10.1021/acs.jmedchem.6b01450. Epub 2016 Dec 2.


Meeting report: Third Summer School on Innovative Approaches for Identification of Antiviral Agents (IAAASS).

Le Grice SF, Sztuba-Solinska J, Maccioni E, Purzycka KJ, Parolin C, Tramontano E.

Antiviral Res. 2017 Mar;139:13-17. doi: 10.1016/j.antiviral.2016.12.004. Epub 2016 Dec 8.


A small stem-loop structure of the Ebola virus trailer is essential for replication and interacts with heat-shock protein A8.

Sztuba-Solinska J, Diaz L, Kumar MR, Kolb G, Wiley MR, Jozwick L, Kuhn JH, Palacios G, Radoshitzky SR, J Le Grice SF, Johnson RF.

Nucleic Acids Res. 2016 Nov 16;44(20):9831-9846. Epub 2016 Sep 19.

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