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Items: 1 to 20 of 34

1.

Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome.

El-Kasaby A, Kasture A, Koban F, Hotka M, Asjad HMM, Kubista H, Freissmuth M, Sucic S.

Neuropharmacology. 2019 Mar 15. pii: S0028-3908(19)30100-5. doi: 10.1016/j.neuropharm.2019.03.015. [Epub ahead of print]

2.

Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction.

Kasture AS, Bartel D, Steinkellner T, Sucic S, Hummel T, Freissmuth M.

Neuropharmacology. 2019 Mar 6. pii: S0028-3908(19)30084-X. doi: 10.1016/j.neuropharm.2019.03.007. [Epub ahead of print]

3.

Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum.

Kovalchuk V, Samluk Ł, Juraszek B, Jurkiewicz-Trząska D, Sucic S, Freissmuth M, Nałęcz KA.

Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):252-263. doi: 10.1016/j.bbamcr.2018.11.005. Epub 2018 Nov 14.

4.

Standardized phytotherapic extracts rescue anomalous locomotion and electrophysiological responses of TDP-43 Drosophila melanogaster model of ALS.

Maccioni R, Setzu MD, Talani G, Solari P, Kasture A, Sucic S, Porru S, Muroni P, Sanna E, Kasture S, Acquas E, Liscia A.

Sci Rep. 2018 Oct 30;8(1):16002. doi: 10.1038/s41598-018-34452-1.

5.

Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems.

Kasture AS, Hummel T, Sucic S, Freissmuth M.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1788. doi: 10.3390/ijms19061788. Review.

6.

Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.

Asjad HMM, Nasrollahi-Shirazi S, Sucic S, Freissmuth M, Nanoff C.

Int J Mol Sci. 2017 Nov 14;18(11). pii: E2416. doi: 10.3390/ijms18112416. Review.

7.

SLC6 Transporter Folding Diseases and Pharmacochaperoning.

Freissmuth M, Stockner T, Sucic S.

Handb Exp Pharmacol. 2018;245:249-270. doi: 10.1007/164_2017_71. Review.

PMID:
29086036
8.

Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism.

Asjad HMM, Kasture A, El-Kasaby A, Sackel M, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2017 Nov 24;292(47):19250-19265. doi: 10.1074/jbc.M117.797092. Epub 2017 Sep 29.

9.

An unfolding story: Small molecules remedy misfolded monoamine transporters.

Kasture A, Stockner T, Freissmuth M, Sucic S.

Int J Biochem Cell Biol. 2017 Nov;92:1-5. doi: 10.1016/j.biocel.2017.09.004. Epub 2017 Sep 7. Review.

10.

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M.

J Biol Chem. 2017 Oct 6;292(40):16773-16786. doi: 10.1074/jbc.M117.794081. Epub 2017 Aug 23.

11.

When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters.

Sucic S, Kasture A, Mazhar Asjad HM, Kern C, El-Kasaby A, Freissmuth M.

J Neurol Neuromedicine. 2016 Dec 30;1(9):34-40.

12.

The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.

Kern C, Erdem FA, El-Kasaby A, Sandtner W, Freissmuth M, Sucic S.

J Biol Chem. 2017 Mar 3;292(9):3603-3613. doi: 10.1074/jbc.M116.771360. Epub 2017 Jan 19.

13.

Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells.

Schaletzki Y, Kromrey ML, Bröderdorf S, Hammer E, Grube M, Hagen P, Sucic S, Freissmuth M, Völker U, Greinacher A, Rauch BH, Kroemer HK, Jedlitschky G.

Thromb Haemost. 2017 Jan 5;117(1):105-115. doi: 10.1160/TH16-01-0045. Epub 2016 Oct 20.

PMID:
27761583
14.

Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.

Kasture A, El-Kasaby A, Szöllősi D, Asjad HMM, Grimm A, Stockner T, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2016 Sep 30;291(40):20876-20890. doi: 10.1074/jbc.M116.737551. Epub 2016 Aug 1.

15.

Comparison of the β-Adrenergic Receptor Antagonists Landiolol and Esmolol: Receptor Selectivity, Partial Agonism, and Pharmacochaperoning Actions.

Nasrollahi-Shirazi S, Sucic S, Yang Q, Freissmuth M, Nanoff C.

J Pharmacol Exp Ther. 2016 Oct;359(1):73-81. doi: 10.1124/jpet.116.232884. Epub 2016 Jul 22.

PMID:
27451411
16.

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1719-22. doi: 10.1002/anie.201508755. Epub 2015 Dec 22.

17.

Corrigendum: STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behaviour.

Kong E, Sucic S, Monje FJ, Reisinger SN, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD.

Sci Rep. 2015 Jul 15;5:11965. doi: 10.1038/srep11965. No abstract available.

18.

Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W.

Mol Pharmacol. 2015 Jul;88(1):12-8. doi: 10.1124/mol.115.099036. Epub 2015 Apr 14.

PMID:
25873594
19.

A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.

Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2015 May 22;290(21):13263-78. doi: 10.1074/jbc.M115.641357. Epub 2015 Apr 13.

20.

STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior.

Kong E, Sucic S, Monje FJ, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD.

Sci Rep. 2015 Mar 11;5:9009. doi: 10.1038/srep09009. Erratum in: Sci Rep. 2015;5:11965.

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