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Items: 1 to 20 of 40


Binge Drinking.

White AM, Tapert S, Shukla SD.

Alcohol Res. 2018;39(1):1-3. No abstract available.


Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation.

Restrepo RJ, Lim RW, Korthuis RJ, Shukla SD.

Alcohol. 2017 May;60:77-82. doi: 10.1016/j.alcohol.2017.01.009. Epub 2017 Mar 12.


High Intrinsic Aerobic Capacity Protects against Ethanol-Induced Hepatic Injury and Metabolic Dysfunction: Study Using High Capacity Runner Rat Model.

Szary N, Rector RS, Uptergrove GM, Ridenhour SE, Shukla SD, Thyfault JP, Koch LG, Britton SL, Ibdah JA.

Biomolecules. 2015 Nov 20;5(4):3295-308. doi: 10.3390/biom5043295.


In Vivo Acute on Chronic Ethanol Effects in Liver: A Mouse Model Exhibiting Exacerbated Injury, Altered Metabolic and Epigenetic Responses.

Shukla SD, Aroor AR, Restrepo R, Kharbanda KK, Ibdah JA.

Biomolecules. 2015 Nov 20;5(4):3280-94. doi: 10.3390/biom5043280.


Erratum to: Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.

Aroor AR, Restrepo RJ, Kharbanda KK, Shukla SD.

Hepatol Int. 2014 Sep;8 Suppl 2:431. doi: 10.1007/s12072-014-9564-2. No abstract available.


Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.

Aroor AR, Restrepo RJ, Kharbanda KK, Shukla SD.

Hepatol Int. 2014 Sep;8 Suppl 2:421-30. doi: 10.1007/s12072-014-9546-4. Epub 2014 Jun 18. Erratum in: Hepatol Int. 2014 Sep;8 Suppl 2:431.


Different mechanisms for histone acetylation by ethanol and its metabolite acetate in rat primary hepatocytes.

Shukla SD, Restrepo R, Fish P, Lim RW, Ibdah JA.

J Pharmacol Exp Ther. 2015 Jul;354(1):18-23. doi: 10.1124/jpet.115.223867. Epub 2015 Apr 17.


Epigenetic effects of ethanol on the liver and gastrointestinal system.

Shukla SD, Lim RW.

Alcohol Res. 2013;35(1):47-55. Review.


Epigenetics--new frontier for alcohol research.

Shukla SD, Zakhari S.

Alcohol Res. 2013;35(1):1-2. No abstract available.


Binge ethanol and liver: new molecular developments.

Shukla SD, Pruett SB, Szabo G, Arteel GE.

Alcohol Clin Exp Res. 2013 Apr;37(4):550-7. doi: 10.1111/acer.12011. Epub 2013 Jan 24. Review.


A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats.

Aroor AR, Roy LJ, Restrepo RJ, Mooney BP, Shukla SD.

Proteome Sci. 2012 Apr 30;10(1):29. doi: 10.1186/1477-5956-10-29.


Gene-selective histone H3 acetylation in the absence of increase in global histone acetylation in liver of rats chronically fed alcohol.

Park PH, Lim RW, Shukla SD.

Alcohol Alcohol. 2012 May-Jun;47(3):233-9. doi: 10.1093/alcalc/ags004. Epub 2012 Feb 2.


Dysregulated phosphorylation and nuclear translocation of cyclic AMP response element binding protein (CREB) in rat liver after chronic ethanol binge.

Aroor AR, Jackson DE, Shukla SD.

Eur J Pharmacol. 2012 Mar 15;679(1-3):101-8. doi: 10.1016/j.ejphar.2011.12.045. Epub 2012 Jan 15.


Histone H3 phosphorylation (Ser10, Ser28) and phosphoacetylation (K9S10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol.

James TT, Aroor AR, Lim RW, Shukla SD.

J Pharmacol Exp Ther. 2012 Feb;340(2):237-47. doi: 10.1124/jpet.111.186775. Epub 2011 Oct 24.


Binge ethanol intake in chronically exposed rat liver decreases LDL-receptor and increases angiotensinogen gene expression.

Aroor AR, Shukla SD.

World J Hepatol. 2011 Sep 27;3(9):250-5. doi: 10.4254/wjh.v3.i9.250.


Elevated activation of ERK1 and ERK2 accompany enhanced liver injury following alcohol binge in chronically ethanol-fed rats.

Aroor AR, Jackson DE, Shukla SD.

Alcohol Clin Exp Res. 2011 Dec;35(12):2128-38. doi: 10.1111/j.1530-0277.2011.01577.x. Epub 2011 Jul 25.


Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells.

Choudhury M, Pandey RS, Clemens DL, Davis JW, Lim RW, Shukla SD.

Alcohol. 2011 Jun;45(4):311-24. doi: 10.1016/j.alcohol.2010.12.003. Epub 2011 Mar 2.


Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.

Nichols LA, Jackson DE, Manthey JA, Shukla SD, Holland LJ.

Lipids Health Dis. 2011 Feb 23;10:36. doi: 10.1186/1476-511X-10-36.


Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes.

Choudhury M, Park PH, Jackson D, Shukla SD.

Alcohol. 2010 Sep;44(6):531-40. doi: 10.1016/j.alcohol.2010.06.003. Epub 2010 Aug 12.


Differential changes in MAP kinases, histone modifications, and liver injury in rats acutely treated with ethanol.

Aroor AR, James TT, Jackson DE, Shukla SD.

Alcohol Clin Exp Res. 2010 Sep 1;34(9):1543-51. doi: 10.1111/j.1530-0277.2010.01239.x. Epub 2010 Jun 25.

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