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Items: 1 to 20 of 65


In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials.

Evans SJ, Clift MJD, Singh N, Wills JW, Hondow N, Wilkinson TS, Burgum MJ, Brown AP, Jenkins GJ, Doak SH.

Part Fibre Toxicol. 2019 Feb 13;16(1):8. doi: 10.1186/s12989-019-0291-7.


Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro.

Verma JR, Harte DSG, Shah UK, Summers H, Thornton CA, Doak SH, Jenkins GJS, Rees P, Wills JW, Johnson GE.

Mutagenesis. 2018 Oct 11;33(4):283-289. doi: 10.1093/mutage/gey021.


Reprint of: A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies.

Shah UK, Mallia JO, Singh N, Chapman KE, Doak SH, Jenkins GJS.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Oct;834:35-41. doi: 10.1016/j.mrgentox.2018.06.020. Epub 2018 Aug 18.


Genotoxicity Assessment of Nanomaterials: Recommendations on Best Practices, Assays, and Methods.

Elespuru R, Pfuhler S, Aardema MJ, Chen T, Doak SH, Doherty A, Farabaugh CS, Kenny J, Manjanatha M, Mahadevan B, Moore MM, Ouédraogo G, Stankowski LF Jr, Tanir JY.

Toxicol Sci. 2018 Aug 1;164(2):391-416. doi: 10.1093/toxsci/kfy100.


STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells.

Burnell SEA, Spencer-Harty S, Howarth S, Bodger O, Kynaston H, Morgan C, Doak SH.

Sci Rep. 2018 Apr 19;8(1):6252. doi: 10.1038/s41598-018-24655-x.


A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies.

Shah UK, Mallia JO, Singh N, Chapman KE, Doak SH, Jenkins GJS.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Jan;825:51-58. doi: 10.1016/j.mrgentox.2017.12.005. Epub 2017 Dec 15.


A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells.

Wilde EC, Chapman KE, Stannard LM, Seager AL, Brüsehafer K, Shah UK, Tonkin JA, Brown MR, Verma JR, Doherty AT, Johnson GE, Doak SH, Jenkins GJS.

Arch Toxicol. 2018 Feb;92(2):935-951. doi: 10.1007/s00204-017-2102-y. Epub 2017 Nov 6.


Characterizing Nanoparticles in Biological Matrices: Tipping Points in Agglomeration State and Cellular Delivery In Vitro.

Wills JW, Summers HD, Hondow N, Sooresh A, Meissner KE, White PA, Rees P, Brown A, Doak SH.

ACS Nano. 2017 Dec 26;11(12):11986-12000. doi: 10.1021/acsnano.7b03708. Epub 2017 Nov 1.


Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities?

Burden N, Aschberger K, Chaudhry Q, Clift MJD, Fowler P, Johnston H, Landsiedel R, Rowland J, Stone V, Doak SH.

Regul Toxicol Pharmacol. 2017 Dec;91:257-266. doi: 10.1016/j.yrtph.2017.10.021. Epub 2017 Oct 22.


Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways.

Singh N, Nelson BC, Scanlan LD, Coskun E, Jaruga P, Doak SH.

Int J Mol Sci. 2017 Jul 13;18(7). pii: E1515. doi: 10.3390/ijms18071515. Review.


Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N-methyl-N-nitrosourea.

Chapman KE, Hoffmann GR, Doak SH, Jenkins GJS.

Mutat Res. 2017 Jul;819:38-46. doi: 10.1016/j.mrgentox.2017.05.002. Epub 2017 May 4.


The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile.

Manshian BB, Martens TF, Kantner K, Braeckmans K, De Smedt SC, Demeester J, Jenkins GJS, Parak WJ, Pelaz B, Doak SH, Himmelreich U, Soenen SJ.

J Nanobiotechnology. 2017 Jun 15;15(1):45. doi: 10.1186/s12951-017-0279-0.


Choose your cell model wisely: The in vitro nanoneurotoxicity of differentially coated iron oxide nanoparticles for neural cell labeling.

Joris F, Valdepérez D, Pelaz B, Wang T, Doak SH, Manshian BB, Soenen SJ, Parak WJ, De Smedt SC, Raemdonck K.

Acta Biomater. 2017 Jun;55:204-213. doi: 10.1016/j.actbio.2017.03.053. Epub 2017 Apr 1.


Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice.

Al-Himdani S, Jessop ZM, Al-Sabah A, Combellack E, Ibrahim A, Doak SH, Hart AM, Archer CW, Thornton CA, Whitaker IS.

Front Surg. 2017 Feb 23;4:4. doi: 10.3389/fsurg.2017.00004. eCollection 2017. Review.


NanoGenotoxicology: present and the future.

Doak SH, Dusinska M.

Mutagenesis. 2017 Jan;32(1):1-4. doi: 10.1093/mutage/gew066.


Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells.

Verma JR, Rees BJ, Wilde EC, Thornton CA, Jenkins GJS, Doak SH, Johnson GE.

Arch Toxicol. 2017 Jul;91(7):2689-2698. doi: 10.1007/s00204-016-1903-8. Epub 2016 Dec 10.


Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity.

Evans SJ, Clift MJ, Singh N, de Oliveira Mallia J, Burgum M, Wills JW, Wilkinson TS, Jenkins GJ, Doak SH.

Mutagenesis. 2017 Jan;32(1):233-241. doi: 10.1093/mutage/gew054. Epub 2016 Nov 4. Review.


Coating of Quantum Dots strongly defines their effect on lysosomal health and autophagy.

Peynshaert K, Soenen SJ, Manshian BB, Doak SH, Braeckmans K, De Smedt SC, Remaut K.

Acta Biomater. 2017 Jan 15;48:195-205. doi: 10.1016/j.actbio.2016.10.022. Epub 2016 Oct 17.


Is Nickel Chloride really a Non-Genotoxic Carcinogen?

Stannard L, Doak SH, Doherty A, Jenkins GJ.

Basic Clin Pharmacol Toxicol. 2017 Sep;121 Suppl 3:10-15. doi: 10.1111/bcpt.12689. Epub 2016 Dec 22. Review.


A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity.

Shah UK, Seager AL, Fowler P, Doak SH, Johnson GE, Scott SJ, Scott AD, Jenkins GJ.

Mutat Res Genet Toxicol Environ Mutagen. 2016 Sep 15;808:8-19. doi: 10.1016/j.mrgentox.2016.06.009. Epub 2016 Jul 26.


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