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Items: 1 to 20 of 133


Prediction of human pharmacokinetics of antibody-drug conjugates from nonclinical data.

Li C, Zhang C, Deng R, Leipold D, Li D, Latifi B, Gao Y, Zhang C, Li Z, Miles D, Chen SC, Samineni D, Wang B, Agarwal P, Lu D, Prabhu S, Girish S, Kamath AV.

Clin Transl Sci. 2019 May 22. doi: 10.1111/cts.12649. [Epub ahead of print]


FSCN1 is an effective marker of poor prognosis and a potential therapeutic target in human tongue squamous cell carcinoma.

Chen Y, Tian T, Li ZY, Wang CY, Deng R, Deng WY, Yang AK, Chen YF, Li H.

Cell Death Dis. 2019 May 1;10(5):356. doi: 10.1038/s41419-019-1574-5.


G-CSF-mobilized Peripheral Blood Mononuclear Cells Combined with Platelet-rich Plasma Accelerates Restoration of Ovarian Function in Cyclophosphamide-induced POI Rats.

Huang Q, Liu B, Jiang R, Liao S, Wei Z, Bi Y, Liu X, Deng R, Jin Y, Tan Y, Yang Y, Qin A.

Biol Reprod. 2019 Apr 29. pii: ioz077. doi: 10.1093/biolre/ioz077. [Epub ahead of print]


An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.

Chung S, Nguyen V, Lin YL, Lafrance-Vanasse J, Scales SJ, Lin K, Deng R, Williams K, Sperinde G, Li JJ, Zheng K, Sukumaran S, Tesar D, Ernst JA, Fischer S, Lazar GA, Prabhu S, Song A.

MAbs. 2019 Apr 29:1-14. doi: 10.1080/19420862.2019.1605270. [Epub ahead of print]


Regorafenib Promotes Antitumor Immunity via Inhibiting PD-L1 and IDO1 Expression in Melanoma.

Wu RY, Kong PF, Xia LP, Huang Y, Li ZL, Tang YY, Chen YH, Li X, Senthilkumar R, Zhang HL, Sun T, Xu XL, Yu Y, Mai J, Peng XD, Yang D, Zhou LH, Feng GK, Deng R, Zhu XF.

Clin Cancer Res. 2019 Apr 2. doi: 10.1158/1078-0432.CCR-18-2840. [Epub ahead of print]


Multifunctional Gold Nanoparticles Overcome MicroRNA Regulatory Network Mediated-Multidrug Resistant Leukemia.

Deng R, Ji B, Yu H, Bao W, Yang Z, Yu Y, Cui Y, Du Y, Song M, Liu S, Meguellati K, Yan F.

Sci Rep. 2019 Mar 29;9(1):5348. doi: 10.1038/s41598-019-41866-y.


A phase 1, randomized, single ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of DSTA4637S, an anti-Staphylococcus aureus THIOMAB™ antibody-antibiotic conjugate, in healthy volunteers.

Peck M, Rothenberg ME, Deng R, Lewin-Koh N, She G, Kamath AV, Carrasco-Triguero M, Saad O, Castro A, Teufel L, Dickerson DS, Leonardelli M, Tavel JA.

Antimicrob Agents Chemother. 2019 Mar 25. pii: AAC.02588-18. doi: 10.1128/AAC.02588-18. [Epub ahead of print]


Investigating Dynamic Molecular Events in Melanoma Cell Nucleus During Photodynamic Therapy by SERS.

Yue J, Liang L, Shen Y, Guan X, Zhang J, Li Z, Deng R, Xu S, Liang C, Shi W, Xu W.

Front Chem. 2019 Jan 28;6:665. doi: 10.3389/fchem.2018.00665. eCollection 2018.


Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy.

Yuan MX, Qiu Y, Ran YQ, Feng GK, Deng R, Zhu XF, Lan WJ, Li HJ.

Mar Drugs. 2019 Jan 23;17(2). pii: E77. doi: 10.3390/md17020077.


Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer.

Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, Huang WC, Chiang SF, Nie L, Hou J, Chen CT, Huo L, Yang WH, Deng R, Nakai K, Hsu YH, Chang SS, Chiu TJ, Tang J, Zhang R, Wang L, Fang B, Chen T, Wong KK, Hsu JL, Hung MC.

Cancer Cell. 2018 Dec 10;34(6):954-969.e4. doi: 10.1016/j.ccell.2018.11.007.


Performance of serum HBcrAg in chronic hepatitis B patients with 8-year nucleos(t)ide analogs therapy.

Wang ML, Deng R, Chen EQ, Tao CM, Liao J, Zhou TY, Wang J, Tang H.

Clin Res Hepatol Gastroenterol. 2018 Nov 26. pii: S2210-7401(18)30256-0. doi: 10.1016/j.clinre.2018.10.020. [Epub ahead of print]


Resolution of unexpected pregnancy-related findings in a rat embryofetal development and toxicokinetic study of monoclonal antibodies specific for hCMV.

Katavolos P, Prell R, Zane D, Deng R, Halpern W.

Birth Defects Res. 2018 Nov 1;110(18):1347-1357. doi: 10.1002/bdr2.1402. Epub 2018 Oct 31.


Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis.

Zhang H, Wang Y, Dou J, Guo Y, He J, Li L, Liu X, Chen R, Deng R, Huang J, Xie R, Zhao X, Yu J.

Oncogene. 2019 Feb;38(9):1410-1431. doi: 10.1038/s41388-018-0530-7. Epub 2018 Oct 10.


SMAR1 promotes immune escape of Tri-negative Breast Cancer through a mechanism involving T-bet/PD-1 Axis.

Xiaohua W, Hongxia X, Rong D, Pingping W, Xing H, Yichao Z, Cheng C.

Cell Mol Biol (Noisy-le-grand). 2018 Sep 30;64(12):70-75.


In situ exploration of characteristics of macropinocytosis and size range of internalized substances in cells by 3D-structured illumination microscopy.

Jin J, Shen Y, Zhang B, Deng R, Huang D, Lu T, Sun F, Xu S, Liang C.

Int J Nanomedicine. 2018 Sep 12;13:5321-5333. doi: 10.2147/IJN.S171973. eCollection 2018.


Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model.

Wang-Lin SX, Zhou C, Kamath AV, Hong K, Koppada N, Saad OM, Carrasco-Triguero M, Khojasteh C, Deng R.

MAbs. 2018 Oct;10(7):1131-1143. doi: 10.1080/19420862.2018.1494478. Epub 2018 Aug 6.


[Shufeng Huoxue Formula suppresses proliferation and regulates melanin metabolism in murine B16 melanoma cells in vitro through autophagy pathway].

Geng YW, Wang YL, Deng R, Fu KL, Deng Y.

Nan Fang Yi Ke Da Xue Xue Bao. 2018 May 20;38(5):630-634. Chinese.


Correction: Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.

Shan J, Zhao B, Shan Z, Nie J, Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Liang R, Li D, Sun B, Lavillette D, Xu K, Li B.

PLoS Pathog. 2018 Apr 30;14(4):e1007037. doi: 10.1371/journal.ppat.1007037. eCollection 2018 Apr.


XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells.

Ji J, Yu Y, Li ZL, Chen MY, Deng R, Huang X, Wang GF, Zhang MX, Yang Q, Ravichandran S, Feng GK, Xu XL, Yang CL, Qiu MZ, Jiao L, Yang D, Zhu XF.

Theranostics. 2018 Feb 5;8(6):1494-1510. doi: 10.7150/thno.21717. eCollection 2018.

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