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Items: 1 to 20 of 38

1.

Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models.

Alarcan J, Dubreil E, Huguet A, Aráoz R, Brée F, Bouaita B, Hurtaud-Pessel D, Braeuning A, Hessel-Pras S, Lampen A, Le Hégarat L, Fessard V.

Toxicol Lett. 2019 Jun 1;307:17-25. doi: 10.1016/j.toxlet.2019.02.012. Epub 2019 Feb 27.

PMID:
30825503
2.

Di- and heptavalent nicotinic analogues to interfere with α7 nicotinic acetylcholine receptors.

Brissonnet Y, Araoz R, Sousa R, Percevault L, Brument S, Deniaud D, Servent D, Le Questel JY, Lebreton J, Gouin SG.

Bioorg Med Chem. 2019 Mar 1;27(5):700-707. doi: 10.1016/j.bmc.2019.01.013. Epub 2019 Jan 17.

PMID:
30692022
3.

Prorocentrolide-A from Cultured Prorocentrum lima Dinoflagellates Collected in Japan Blocks Sub-Types of Nicotinic Acetylcholine Receptors.

Amar M, Aráoz R, Iorga BI, Yasumoto T, Servent D, Molgó J.

Toxins (Basel). 2018 Feb 28;10(3). pii: E97. doi: 10.3390/toxins10030097.

4.

Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors.

Molgó J, Marchot P, Aráoz R, Benoit E, Iorga BI, Zakarian A, Taylor P, Bourne Y, Servent D.

J Neurochem. 2017 Aug;142 Suppl 2:41-51. doi: 10.1111/jnc.13995. Epub 2017 Mar 21. Review.

5.

Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry.

Echterbille J, Gilles N, Araóz R, Mourier G, Amar M, Servent D, De Pauw E, Quinton L.

Toxicon. 2017 May;130:1-10. doi: 10.1016/j.toxicon.2017.02.023. Epub 2017 Feb 24.

PMID:
28238803
6.

The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors.

Couesnon A, Aráoz R, Iorga BI, Benoit E, Reynaud M, Servent D, Molgó J.

Toxins (Basel). 2016 Aug 24;8(9). pii: E249. doi: 10.3390/toxins8090249.

7.

The Neurotoxic Effect of 13,19-Didesmethyl and 13-Desmethyl Spirolide C Phycotoxins Is Mainly Mediated by Nicotinic Rather Than Muscarinic Acetylcholine Receptors.

Aráoz R, Ouanounou G, Iorga BI, Goudet A, Alili D, Amar M, Benoit E, Molgó J, Servent D.

Toxicol Sci. 2015 Sep;147(1):156-67. doi: 10.1093/toxsci/kfv119. Epub 2015 Jun 10.

PMID:
26063663
8.

Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α1(2)βγδ nAChRs.

Bourne Y, Sulzenbacher G, Radić Z, Aráoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgó J, Taylor P, Marchot P.

Structure. 2015 Jun 2;23(6):1106-15. doi: 10.1016/j.str.2015.04.009. Epub 2015 May 21.

9.

Isolation, purification and functional characterization of alpha-BnIA from Conus bandanus venom.

Nguyen B, Le Caer JP, Aráoz R, Thai R, Lamthanh H, Benoit E, Molgó J.

Toxicon. 2014 Dec;91:155-63. doi: 10.1016/j.toxicon.2014.10.006. Epub 2014 Oct 15.

PMID:
25449095
10.

Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins.

Stivala CE, Benoit E, Aráoz R, Servent D, Novikov A, Molgó J, Zakarian A.

Nat Prod Rep. 2015 Mar;32(3):411-35. doi: 10.1039/c4np00089g. Review.

11.

Colorimetric microtiter plate receptor-binding assay for the detection of freshwater and marine neurotoxins targeting the nicotinic acetylcholine receptors.

Rubio F, Kamp L, Carpino J, Faltin E, Loftin K, Molgó J, Aráoz R.

Toxicon. 2014 Dec;91:45-56. doi: 10.1016/j.toxicon.2014.08.073. Epub 2014 Sep 27.

PMID:
25260255
12.

Detection of anatoxin-a and three analogs in Anabaena spp. cultures: new fluorescence polarization assay and toxin profile by LC-MS/MS.

Sanchez JA, Otero P, Alfonso A, Ramos V, Vasconcelos V, Aráoz R, Molgó J, Vieytes MR, Botana LM.

Toxins (Basel). 2014 Jan 24;6(2):402-15. doi: 10.3390/toxins6020402.

13.

Physical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors.

Molgó J, Aráoz R, Benoit E, Iorga BI.

Expert Opin Drug Discov. 2013 Oct;8(10):1203-23. doi: 10.1517/17460441.2013.822365. Epub 2013 Aug 6. Review.

PMID:
23919818
14.

High-throughput receptor-based assay for the detection of spirolides by chemiluminescence.

Rodríguez LP, Vilariño N, Molgó J, Aráoz R, Botana LM.

Toxicon. 2013 Dec 1;75:35-43. doi: 10.1016/j.toxicon.2013.06.015. Epub 2013 Jul 1.

PMID:
23827412
15.

Pinnatoxin G is responsible for atypical toxicity in mussels (Mytilus galloprovincialis) and clams (Venerupis decussata) from Ingril, a French Mediterranean lagoon.

Hess P, Abadie E, Hervé F, Berteaux T, Séchet V, Aráoz R, Molgó J, Zakarian A, Sibat M, Rundberget T, Miles CO, Amzil Z.

Toxicon. 2013 Dec 1;75:16-26. doi: 10.1016/j.toxicon.2013.05.001. Epub 2013 May 30.

16.

Development of a solid-phase receptor-based assay for the detection of cyclic imines using a microsphere-flow cytometry system.

Rodríguez LP, Vilariño N, Molgó J, Aráoz R, Louzao MC, Taylor P, Talley T, Botana LM.

Anal Chem. 2013 Feb 19;85(4):2340-7. doi: 10.1021/ac3033432. Epub 2013 Feb 7.

17.

Toxicity of the synthetic polymeric 3-alkylpyridinium salt (APS3) is due to specific block of nicotinic acetylcholine receptors.

Grandič M, Aráoz R, Molgó J, Turk T, Sepčić K, Benoit E, Frangež R.

Toxicology. 2013 Jan 7;303:25-33. doi: 10.1016/j.tox.2012.10.013. Epub 2012 Nov 9.

PMID:
23146756
18.

Coupling the Torpedo microplate-receptor binding assay with mass spectrometry to detect cyclic imine neurotoxins.

Aráoz R, Ramos S, Pelissier F, Guérineau V, Benoit E, Vilariño N, Botana LM, Zakarian A, Molgó J.

Anal Chem. 2012 Dec 4;84(23):10445-53. doi: 10.1021/ac3027564. Epub 2012 Nov 21.

19.

The non-competitive acetylcholinesterase inhibitor APS12-2 is a potent antagonist of skeletal muscle nicotinic acetylcholine receptors.

Grandič M, Aráoz R, Molgó J, Turk T, Sepčić K, Benoit E, Frangež R.

Toxicol Appl Pharmacol. 2012 Dec 1;265(2):221-8. doi: 10.1016/j.taap.2012.09.024. Epub 2012 Oct 6.

PMID:
23046821
20.

6,6-Spiroimine analogs of (-)-gymnodimine A: synthesis and biological evaluation on nicotinic acetylcholine receptors.

Duroure L, Jousseaume T, Aráoz R, Barré E, Retailleau P, Chabaud L, Molgó J, Guillou C.

Org Biomol Chem. 2011 Dec 7;9(23):8112-8. doi: 10.1039/c1ob06257c. Epub 2011 Oct 24.

PMID:
22024965

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