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Items: 1 to 20 of 51

1.

Thiazolidinone/thiazole based hybrids - New class of antitrypanosomal agents.

Kryshchyshyn A, Kaminskyy D, Karpenko O, Gzella A, Grellier P, Lesyk R.

Eur J Med Chem. 2019 Jul 15;174:292-308. doi: 10.1016/j.ejmech.2019.04.052. Epub 2019 Apr 24.

PMID:
31051403
2.

Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity.

Holota S, Kryshchyshyn A, Derkach H, Trufin Y, Demchuk I, Gzella A, Grellier P, Lesyk R.

Bioorg Chem. 2019 May;86:126-136. doi: 10.1016/j.bioorg.2019.01.045. Epub 2019 Jan 22.

PMID:
30690336
3.

Isothiochromenothiazoles-A Class of Fused Thiazolidinone Derivatives with Established Anticancer Activity That Inhibits Growth of Trypanosoma brucei brucei.

Kryshchyshyn A, Kaminskyy D, Nektegayev I, Grellier P, Lesyk R.

Sci Pharm. 2018 Oct 19;86(4). pii: E47. doi: 10.3390/scipharm86040047.

4.

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry.

Kryshchyshyn A, Roman O, Lozynskyi A, Lesyk R.

Sci Pharm. 2018 Jun 14;86(2). pii: E26. doi: 10.3390/scipharm86020026. Review.

5.

HYBRIDS OF OLEANOLIC ACID WITH NORBORNENE-2,3-DICARBOXIMIDE-N- CARBOXYLIC ACIDS AS POTENTIAL ANTICANCER AGENTS.

Bednarczyk-Cwynar B, Ruszkowskp P, Atamanyuk D, Lesyk R, Zaprutko L.

Acta Pol Pharm. 2017 May;74(3):827-835.

6.

Development of Predictive QSAR Models of 4-Thiazolidinones Antitrypanosomal Activity Using Modern Machine Learning Algorithms.

Kryshchyshyn A, Devinyak O, Kaminskyy D, Grellier P, Lesyk R.

Mol Inform. 2018 May;37(5):e1700078. doi: 10.1002/minf.201700078. Epub 2017 Nov 14.

PMID:
29134756
7.

Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy.

Sklyarova Y, Fomenko I, Lozynska I, Lozynskyi A, Lesyk R, Sklyarov A.

Sci Pharm. 2017 Oct 24;85(4). pii: E35. doi: 10.3390/scipharm85040035.

8.

Anticancer properties of 4-thiazolidinone derivatives depend on peroxisome proliferator-activated receptor gamma (PPARγ).

Szychowski KA, Leja ML, Kaminskyy DV, Kryshchyshyn AP, Binduga UE, Pinyazhko OR, Lesyk RB, Tobiasz J, Gmiński J.

Eur J Med Chem. 2017 Dec 1;141:162-168. doi: 10.1016/j.ejmech.2017.09.071. Epub 2017 Sep 30.

PMID:
29031063
9.

Recent developments with rhodanine as a scaffold for drug discovery.

Kaminskyy D, Kryshchyshyn A, Lesyk R.

Expert Opin Drug Discov. 2017 Dec;12(12):1233-1252. doi: 10.1080/17460441.2017.1388370. Epub 2017 Oct 11. Review.

PMID:
29019278
10.

5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

Kaminskyy D, Kryshchyshyn A, Lesyk R.

Eur J Med Chem. 2017 Nov 10;140:542-594. doi: 10.1016/j.ejmech.2017.09.031. Epub 2017 Sep 20. Review.

PMID:
28987611
11.

Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids.

Lozynskyi A, Zasidko V, Atamanyuk D, Kaminskyy D, Derkach H, Karpenko O, Ogurtsov V, Kutsyk R, Lesyk R.

Mol Divers. 2017 May;21(2):427-436. doi: 10.1007/s11030-017-9737-8. Epub 2017 Apr 19.

PMID:
28424934
12.

Differential pro-apoptotic effects of synthetic 4-thiazolidinone derivative Les-3288, doxorubicin and temozolomide in human glioma U251 cells.

Коbylinska LI, Klyuchivska OY, Grytsyna II, Finiuk N, Panchuk RR, Starykovych MO, Lehka L, Lesyk RB, Zіmenkovsky BS, Stoika RS.

Croat Med J. 2017 Apr 14;58(2):150-159.

13.

4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms.

Finiuk N, Boiko N, Klyuchivska O, Коbylinska L, Kril I, Zimenkovsky B, Lesyk R, Stoika R.

Croat Med J. 2017 Apr 14;58(2):129-139.

14.

Synthesis and evaluation of anticancer activity of 6-pyrazolinylcoumarin derivatives.

Garazd Y, Garazd M, Lesyk R.

Saudi Pharm J. 2017 Feb;25(2):214-223. doi: 10.1016/j.jsps.2016.05.005. Epub 2016 Jun 3.

15.

Study of novel anticancer 4-thiazolidinone derivatives.

Szychowski KA, Leja ML, Kaminskyy DV, Binduga UE, Pinyazhko OR, Lesyk RB, Gmiński J.

Chem Biol Interact. 2017 Jan 25;262:46-56. doi: 10.1016/j.cbi.2016.12.008. Epub 2016 Dec 11.

PMID:
27965178
16.

5-Year Trends in QSAR and its Machine Learning Methods.

Devinyak OT, Lesyk RB.

Curr Comput Aided Drug Des. 2016;12(4):265-271.

PMID:
27156868
17.

Putative anticancer potential of novel 4-thiazolidinone derivatives: cytotoxicity toward rat C6 glioma in vitro and correlation of general toxicity with the balance of free radical oxidation in rats.

Коbylinska LI, Boiko NM, Panchuk RR, Grytsyna II, Klyuchivska OY, Biletska LP, Lesyk RB, Zіmenkovsky BS, Stoika RS.

Croat Med J. 2016 Apr 23;57(2):151-63.

18.

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells.

Senkiv J, Finiuk N, Kaminskyy D, Havrylyuk D, Wojtyra M, Kril I, Gzella A, Stoika R, Lesyk R.

Eur J Med Chem. 2016 Jul 19;117:33-46. doi: 10.1016/j.ejmech.2016.03.089. Epub 2016 Apr 2.

PMID:
27089210
19.

Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids.

Havrylyuk D, Roman O, Lesyk R.

Eur J Med Chem. 2016 May 4;113:145-66. doi: 10.1016/j.ejmech.2016.02.030. Epub 2016 Feb 16. Review.

PMID:
26922234
20.

Antifibrotic and anticancer action of 5-ene amino/iminothiazolidinones.

Kaminskyy D, den Hartog GJM, Wojtyra M, Lelyukh M, Gzella A, Bast A, Lesyk R.

Eur J Med Chem. 2016 Apr 13;112:180-195. doi: 10.1016/j.ejmech.2016.02.011. Epub 2016 Feb 9.

PMID:
26896707

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