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Items: 1 to 20 of 47


One century of ConA and 40 years of ConBr research: A structural review.

Cavada BS, Osterne VJS, Lossio CF, Pinto-Junior VR, Oliveira MV, Silva MTL, Leal RB, Nascimento KS.

Int J Biol Macromol. 2019 May 17. pii: S0141-8130(19)32136-1. doi: 10.1016/j.ijbiomac.2019.05.100. [Epub ahead of print] Review.


Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons.

Colle D, Santos DB, de Souza V, Lopes MW, Leal RB, de Souza Brocardo P, Farina M.

Mol Biol Rep. 2019 Feb;46(1):751-762. doi: 10.1007/s11033-018-4531-y. Epub 2018 Dec 3.


Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.

Leal RB, Lopes MW, Formolo DA, de Carvalho CR, Hoeller AA, Latini A, Sousa DS, Wolf P, Prediger RD, Bortolotto ZA, Linhares MN, Lin K, Walz R.

Mol Psychiatry. 2018 Jun 7. doi: 10.1038/s41380-018-0084-7. [Epub ahead of print]


Crystal structure of DlyL, a mannose-specific lectin from Dioclea lasiophylla Mart. Ex Benth seeds that display cytotoxic effects against C6 glioma cells.

Leal RB, Pinto-Junior VR, Osterne VJS, Wolin IAV, Nascimento APM, Neco AHB, Araripe DA, Welter PG, Neto CC, Correia JLA, Rocha CRC, Nascimento KS, Cavada BS.

Int J Biol Macromol. 2018 Jul 15;114:64-76. doi: 10.1016/j.ijbiomac.2018.03.080. Epub 2018 Mar 17. No abstract available.


Neuropsychological functioning and brain energetics of drug resistant mesial temporal lobe epilepsy patients.

Osório CM, Latini A, Leal RB, de Oliveira Thais MER, Vascouto HD, Remor AP, Lopes MW, Linhares MN, Ben J, de Paula Martins R, Prediger RD, Hoeller AA, Markowitsch HJ, Wolf P, Lin K, Walz R.

Epilepsy Res. 2017 Dec;138:26-31. doi: 10.1016/j.eplepsyres.2017.10.009. Epub 2017 Oct 12.


Structural analysis of Dioclea lasiocarpa lectin: A C6 cells apoptosis-inducing protein.

Nascimento KS, Santiago MQ, Pinto-Junior VR, Osterne VJS, Martins FWV, Nascimento APM, Wolin IAV, Heinrich IA, Martins MGQ, Silva MTL, Lossio CF, Rocha CRC, Leal RB, Cavada BS.

Int J Biochem Cell Biol. 2017 Nov;92:79-89. doi: 10.1016/j.biocel.2017.09.014. Epub 2017 Sep 20.


Behavioral and Neurochemical Consequences of Pentylenetetrazol-Induced Kindling in Young and Middle-Aged Rats.

Hoeller AA, de Carvalho CR, Franco PLC, Formolo DA, Imthon AK, Dos Santos HR, Eidt I, Souza GR, Constantino LC, Ferreira CL, Prediger RD, Bainy Leal R, Walz R.

Pharmaceuticals (Basel). 2017 Sep 13;10(3). pii: E75. doi: 10.3390/ph10030075.


Canavalia bonariensis lectin: Molecular bases of glycoconjugates interaction and antiglioma potential.

Cavada BS, Silva MTL, Osterne VJS, Pinto-Junior VR, Nascimento APM, Wolin IAV, Heinrich IA, Nobre CAS, Moreira CG, Lossio CF, Rocha CRC, Martins JL, Nascimento KS, Leal RB.

Int J Biol Macromol. 2018 Jan;106:369-378. doi: 10.1016/j.ijbiomac.2017.08.023. Epub 2017 Aug 10.


Crystal structure of Pisum arvense seed lectin (PAL) and characterization of its interaction with carbohydrates by molecular docking and dynamics.

Pinto-Junior VR, Santiago MQ, Nobre CB, Osterne VJS, Leal RB, Cajazeiras JB, Lossio CF, Rocha BAM, Martins MGQ, Nobre CAS, Silva MTL, Nascimento KS, Cavada BS.

Arch Biochem Biophys. 2017 Sep 15;630:27-37. doi: 10.1016/ Epub 2017 Jul 25.


Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test.

Gonçalves FM, Neis VB, Rieger DK, Peres TV, Lopes MW, Heinrich IA, Costa AP, Rodrigues ALS, Kaster MP, Leal RB.

J Neural Transm (Vienna). 2017 Oct;124(10):1227-1237. doi: 10.1007/s00702-017-1753-4. Epub 2017 Jul 10.


Partial characterization and immobilization in CNBr-activated Sepharose of a native lectin from Platypodium elegans seeds (PELa) and comparative study of edematogenic effect with the recombinant form.

Araripe DA, Pinto-Junior VR, Neco AHB, Santiago MQ, Osterne VJS, Pires AF, Lossio CF, Martins MGQ, Correia JLA, Benevides RG, Leal RB, Assreuy AMS, Nascimento KS, Cavada BS.

Int J Biol Macromol. 2017 Sep;102:323-330. doi: 10.1016/j.ijbiomac.2017.03.193. Epub 2017 Apr 2.


Molecular modeling, docking and dynamics simulations of the Dioclea lasiophylla Mart. Ex Benth seed lectin: An edematogenic and hypernociceptive protein.

Pinto-Junior VR, Osterne VJS, Santiago MQ, Lossio CF, Nagano CS, Rocha CRC, Nascimento JCF, Nascimento FLF, Silva IB, Oliveira AS, Correia JLA, Leal RB, Assreuy AMS, Cavada BS, Nascimento KS.

Biochimie. 2017 Apr;135:126-136. doi: 10.1016/j.biochi.2017.02.002. Epub 2017 Feb 11.


Structural studies of a vasorelaxant lectin from Dioclea reflexa Hook seeds: Crystal structure, molecular docking and dynamics.

Pinto-Junior VR, Osterne VJ, Santiago MQ, Correia JL, Pereira-Junior FN, Leal RB, Pereira MG, Chicas LS, Nagano CS, Rocha BA, Silva-Filho JC, Ferreira WP, Rocha CR, Nascimento KS, Assreuy AM, Cavada BS.

Int J Biol Macromol. 2017 May;98:12-23. doi: 10.1016/j.ijbiomac.2017.01.092. Epub 2017 Jan 24.


Signaling pathways underlying the antidepressant-like effect of inosine in mice.

Gonçalves FM, Neis VB, Rieger DK, Lopes MW, Heinrich IA, Costa AP, Rodrigues ALS, Kaster MP, Leal RB.

Purinergic Signal. 2017 Jun;13(2):203-214. doi: 10.1007/s11302-016-9551-2. Epub 2016 Dec 13.


Structural characterization of a lectin from Canavalia virosa seeds with inflammatory and cytotoxic activities.

Osterne VJS, Silva-Filho JC, Santiago MQ, Pinto-Junior VR, Almeida AC, Barreto AAGC, Wolin IAV, Nascimento APM, Amorim RMF, Rocha BAM, Delatorre P, Nagano CS, Leal RB, Assreuy AMS, Nascimento KS, Cavada BS.

Int J Biol Macromol. 2017 Jan;94(Pt A):271-282. doi: 10.1016/j.ijbiomac.2016.10.020. Epub 2016 Oct 11.


Subchronic administration of ascorbic acid elicits antidepressant-like effect and modulates cell survival signaling pathways in mice.

Moretti M, Budni J, Ribeiro CM, Rieger DK, Leal RB, Rodrigues ALS.

J Nutr Biochem. 2016 Dec;38:50-56. doi: 10.1016/j.jnutbio.2016.09.004. Epub 2016 Sep 14.


Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling.

Neis VB, Moretti M, Bettio LE, Ribeiro CM, Rosa PB, Gonçalves FM, Lopes MW, Leal RB, Rodrigues AL.

Eur Neuropsychopharmacol. 2016 Jun;26(6):959-71. doi: 10.1016/j.euroneuro.2016.03.009. Epub 2016 Mar 26.


Structural analysis of Centrolobium tomentosum seed lectin with inflammatory activity.

Almeida AC, Osterne VJ, Santiago MQ, Pinto-Junior VR, Silva-Filho JC, Lossio CF, Nascimento FL, Almeida RP, Teixeira CS, Leal RB, Delatorre P, Rocha BA, Assreuy AM, Nascimento KS, Cavada BS.

Arch Biochem Biophys. 2016 Apr 15;596:73-83. doi: 10.1016/ Epub 2016 Mar 3.


Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy.

Lopes MW, Lopes SC, Santos DB, Costa AP, Gonçalves FM, de Mello N, Prediger RD, Farina M, Walz R, Leal RB.

Epilepsy Behav. 2016 Feb;55:92-100. doi: 10.1016/j.yebeh.2015.12.001. Epub 2016 Jan 13.


Modulation of Brain Glutathione Reductase and Peroxiredoxin 2 by α-Tocopheryl Phosphate.

Uchoa MF, de Souza LF, Dos Santos DB, Peres TV, Mello DF, Leal RB, Farina M, Dafre AL.

Cell Mol Neurobiol. 2016 Aug;36(6):1015-1022. doi: 10.1007/s10571-015-0298-z. Epub 2016 Jan 9.


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