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Items: 1 to 20 of 32

1.

Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype.

Midgley AC, Oltean S, Hascall V, Woods EL, Steadman R, Phillips AO, Meran S.

Sci Signal. 2017 Nov 21;10(506). pii: eaao1822. doi: 10.1126/scisignal.aao1822.

PMID:
29162741
2.

Hepatocyte Growth Factor Mediates Enhanced Wound Healing Responses and Resistance to Transforming Growth Factor-β₁-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts.

Dally J, Khan JS, Voisey A, Charalambous C, John HL, Woods EL, Steadman R, Moseley R, Midgley AC.

Int J Mol Sci. 2017 Aug 24;18(9). pii: E1843. doi: 10.3390/ijms18091843.

3.

Tumor Necrosis Factor-stimulated Gene 6 (TSG-6)-mediated Interactions with the Inter-α-inhibitor Heavy Chain 5 Facilitate Tumor Growth Factor β1 (TGFβ1)-dependent Fibroblast to Myofibroblast Differentiation.

Martin J, Midgley A, Meran S, Woods E, Bowen T, Phillips AO, Steadman R.

J Biol Chem. 2016 Jun 24;291(26):13789-801. doi: 10.1074/jbc.M115.670521. Epub 2016 May 3.

4.

17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation.

Midgley AC, Morris G, Phillips AO, Steadman R.

Aging Cell. 2016 Jun;15(3):531-41. doi: 10.1111/acel.12462. Epub 2016 Mar 2.

5.

Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype.

Midgley AC, Duggal L, Jenkins R, Hascall V, Steadman R, Phillips AO, Meran S.

J Biol Chem. 2015 May 1;290(18):11218-34. doi: 10.1074/jbc.M114.625939. Epub 2015 Feb 25.

6.

MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts.

Midgley AC, Bowen T, Phillips AO, Steadman R.

Aging Cell. 2014 Apr;13(2):235-44. doi: 10.1111/acel.12167. Epub 2013 Nov 12.

7.

Glycosaminoglycan regulation by VEGFA and VEGFC of the glomerular microvascular endothelial cell glycocalyx in vitro.

Foster RR, Armstrong L, Baker S, Wong DW, Wylie EC, Ramnath R, Jenkins R, Singh A, Steadman R, Welsh GI, Mathieson PW, Satchell SC.

Am J Pathol. 2013 Aug;183(2):604-16. doi: 10.1016/j.ajpath.2013.04.019. Epub 2013 Jun 12.

8.

Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts.

Midgley AC, Rogers M, Hallett MB, Clayton A, Bowen T, Phillips AO, Steadman R.

J Biol Chem. 2013 May 24;288(21):14824-38. doi: 10.1074/jbc.M113.451336. Epub 2013 Apr 15.

9.

Interleukin-1β induces hyaluronan and CD44-dependent cell protrusions that facilitate fibroblast-monocyte binding.

Meran S, Martin J, Luo DD, Steadman R, Phillips A.

Am J Pathol. 2013 Jun;182(6):2223-40. doi: 10.1016/j.ajpath.2013.02.038. Epub 2013 Apr 11.

PMID:
23583650
10.

Tumour necrosis factor-stimulated gene (TSG)-6 controls epithelial-mesenchymal transition of proximal tubular epithelial cells.

Bommaya G, Meran S, Krupa A, Phillips AO, Steadman R.

Int J Biochem Cell Biol. 2011 Dec;43(12):1739-46. doi: 10.1016/j.biocel.2011.08.009. Epub 2011 Aug 16.

PMID:
21864707
11.

Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction.

Meran S, Luo DD, Simpson R, Martin J, Wells A, Steadman R, Phillips AO.

J Biol Chem. 2011 May 20;286(20):17618-30. doi: 10.1074/jbc.M111.226563. Epub 2011 Mar 25.

12.

Fibroblasts and myofibroblasts in renal fibrosis.

Meran S, Steadman R.

Int J Exp Pathol. 2011 Jun;92(3):158-67. doi: 10.1111/j.1365-2613.2011.00764.x. Epub 2011 Feb 28. Review.

13.

Characterisation of the human ADAM15 promoter.

Khammas H, Bowen T, Williams JD, Phillips AO, Steadman R, Martin J.

Nephron Exp Nephrol. 2011;118(2):e27-38. doi: 10.1159/000320698. Epub 2010 Dec 23.

PMID:
21196774
14.

Cancer exosomes trigger fibroblast to myofibroblast differentiation.

Webber J, Steadman R, Mason MD, Tabi Z, Clayton A.

Cancer Res. 2010 Dec 1;70(23):9621-30. doi: 10.1158/0008-5472.CAN-10-1722. Epub 2010 Nov 23.

15.

Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling.

Simpson RM, Wells A, Thomas D, Stephens P, Steadman R, Phillips A.

Am J Pathol. 2010 Mar;176(3):1215-28. doi: 10.2353/ajpath.2010.090802. Epub 2010 Jan 21.

16.

Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation.

Simpson RM, Meran S, Thomas D, Stephens P, Bowen T, Steadman R, Phillips A.

Am J Pathol. 2009 Nov;175(5):1915-28. doi: 10.2353/ajpath.2009.090045. Epub 2009 Oct 1.

17.

Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction.

Zhang L, Bowen T, Grennan-Jones F, Paddon C, Giles P, Webber J, Steadman R, Ludgate M.

J Biol Chem. 2009 Sep 25;284(39):26447-55. doi: 10.1074/jbc.M109.003616. Epub 2009 Jul 24.

18.

Modulation of TGFbeta1-dependent myofibroblast differentiation by hyaluronan.

Webber J, Jenkins RH, Meran S, Phillips A, Steadman R.

Am J Pathol. 2009 Jul;175(1):148-60. doi: 10.2353/ajpath.2009.080837. Epub 2009 Jun 18.

19.

Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype.

Webber J, Meran S, Steadman R, Phillips A.

J Biol Chem. 2009 Apr 3;284(14):9083-92. doi: 10.1074/jbc.M806989200. Epub 2009 Feb 4.

20.

Diabetic nephropathy, inflammation, hyaluronan and interstitial fibrosis.

Lewis A, Steadman R, Manley P, Craig K, de la Motte C, Hascall V, Phillips AO.

Histol Histopathol. 2008 Jun;23(6):731-9. doi: 10.14670/HH-23.731.

PMID:
18366011

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