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Items: 1 to 20 of 57


Identification of the Direct Substrates of the ABL Kinase via Kinase Assay Linked Phosphoproteomics with Multiple Drug Treatments.

Arrington J, Xue L, Wang WH, Geahlen RL, Tao WA.

J Proteome Res. 2019 Apr 5;18(4):1679-1690. doi: 10.1021/acs.jproteome.8b00942. Epub 2019 Mar 21.


Spleen Tyrosine Kinase-Mediated Autophagy Is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer.

Shinde A, Hardy SD, Kim D, Akhand SS, Jolly MK, Wang WH, Anderson JC, Khodadadi RB, Brown WS, George JT, Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, Geahlen RL, Wendt MK.

Cancer Res. 2019 Apr 15;79(8):1831-1843. doi: 10.1158/0008-5472.CAN-18-2636. Epub 2019 Feb 7.


Regulation of epithelial-mesenchymal transition and metastasis by TGF-β, P-bodies, and autophagy.

Hardy SD, Shinde A, Wang WH, Wendt MK, Geahlen RL.

Oncotarget. 2017 Oct 17;8(61):103302-103314. doi: 10.18632/oncotarget.21871. eCollection 2017 Nov 28.


Identification of Upstream Kinases by Fluorescence Complementation Mass Spectrometry.

Zeng L, Wang WH, Arrington J, Shao G, Geahlen RL, Hu CD, Tao WA.

ACS Cent Sci. 2017 Oct 25;3(10):1078-1085. doi: 10.1021/acscentsci.7b00261. Epub 2017 Sep 13.


Measuring nanoscale viscoelastic parameters of cells directly from AFM force-displacement curves.

Efremov YM, Wang WH, Hardy SD, Geahlen RL, Raman A.

Sci Rep. 2017 May 8;7(1):1541. doi: 10.1038/s41598-017-01784-3.


Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease.

Ghosh S, Geahlen RL.

EBioMedicine. 2015 Oct 3;2(11):1785-98. doi: 10.1016/j.ebiom.2015.09.053. eCollection 2015 Nov. Erratum in: EBioMedicine. 2016 Jun;8:349.


A Computational Study of the Effects of Syk Activity on B Cell Receptor Signaling Dynamics.

McGee RL, Krisenko MO, Geahlen RL, Rundell AE, Buzzard GT.

Processes (Basel). 2015 Mar;3(1):75-97. Epub 2015 Feb 11.


Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.

Krisenko MO, Higgins RL, Ghosh S, Zhou Q, Trybula JS, Wang WH, Geahlen RL.

J Biol Chem. 2015 Nov 13;290(46):27803-15. doi: 10.1074/jbc.M115.642900. Epub 2015 Oct 1.


Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscope.

Cartagena-Rivera AX, Wang WH, Geahlen RL, Raman A.

Sci Rep. 2015 Jun 29;5:11692. doi: 10.1038/srep11692.


In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC.

Iliuk A, Jayasundera K, Wang WH, Schluttenhofer R, Geahlen RL, Tao WA.

Int J Mass Spectrom. 2015 Feb 1;377:744-753.


Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.

Krisenko MO, Geahlen RL.

Biochim Biophys Acta. 2015 Jan;1853(1):254-63. doi: 10.1016/j.bbamcr.2014.10.022. Epub 2014 Nov 4. Review.


Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.

Wang WH, Childress MO, Geahlen RL.

Mol Cell Biol. 2014 Oct;34(20):3788-99. doi: 10.1128/MCB.00937-14. Epub 2014 Aug 4.


Getting Syk: spleen tyrosine kinase as a therapeutic target.

Geahlen RL.

Trends Pharmacol Sci. 2014 Aug;35(8):414-22. doi: 10.1016/ Epub 2014 Jun 26. Review.


Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B.

Krisenko MO, Cartagena A, Raman A, Geahlen RL.

Biochemistry. 2015 Jan 13;54(1):60-8. doi: 10.1021/bi500325n. Epub 2014 Jun 18.


Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers.

Jayasundera KB, Iliuk AB, Nguyen A, Higgins R, Geahlen RL, Tao WA.

Anal Chem. 2014 Jul 1;86(13):6363-71. doi: 10.1021/ac500599r. Epub 2014 Jun 20.


Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain.

Chen CH, Piraner D, Gorenstein NM, Geahlen RL, Beth Post C.

Biopolymers. 2013 Nov;99(11):897-907. doi: 10.1002/bip.22371.


Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK.

Huang R, Oh H, Arrendale A, Martin VA, Galan J, Workman EJ, Stout JR, Walczak CE, Tao WA, Borch RF, Geahlen RL.

Biochem Pharmacol. 2013 Sep 1;86(5):597-611. doi: 10.1016/j.bcp.2013.06.024. Epub 2013 Jul 4.


Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics.

Xue L, Geahlen RL, Tao WA.

Mol Cell Proteomics. 2013 Oct;12(10):2969-80. doi: 10.1074/mcp.O113.027722. Epub 2013 Jun 22.


Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells.

Fei B, Yu S, Geahlen RL.

Biochim Biophys Acta. 2013 Oct;1833(10):2153-64. doi: 10.1016/j.bbamcr.2013.05.010. Epub 2013 May 16.


A quantitative proteomics-based competition binding assay to characterize pITAM-protein interactions.

Hu L, Yang L, Lipchik AM, Geahlen RL, Parker LL, Tao WA.

Anal Chem. 2013 May 21;85(10):5071-7. doi: 10.1021/ac400359t. Epub 2013 May 8.

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