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Items: 1 to 20 of 92

1.

Longitudinal characterization of diet-induced genetic murine models of non-alcoholic steatohepatitis with metabolic, histological, and transcriptomic hallmarks of human patients.

Abe N, Kato S, Tsuchida T, Sugimoto K, Saito R, Verschuren L, Kleemann R, Oka K.

Biol Open. 2019 May 1;8(5). pii: bio041251. doi: 10.1242/bio.041251.

2.

Study rationale and protocol of the BARICO study: a longitudinal, prospective, observational study to evaluate the effects of weight loss on brain function and structure after bariatric surgery.

Vreeken D, Wiesmann M, Deden LN, Arnoldussen IAC, Aarts E, Kessels RPC, Kleemann R, Hazebroek EJ, Aarts EO, Kiliaan AJ.

BMJ Open. 2019 Jan 9;9(1):e025464. doi: 10.1136/bmjopen-2018-025464.

3.

FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.

Yakala GK, Cabrera-Fuentes HA, Crespo-Avilan GE, Rattanasopa C, Burlacu A, George BL, Anand K, Mayan DC, Corlianò M, Hernández-Reséndiz S, Wu Z, Schwerk AMK, Tan ALJ, Trigueros-Motos L, Chèvre R, Chua T, Kleemann R, Liehn EA, Hausenloy DJ, Ghosh S, Singaraja RR.

Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):387-401. doi: 10.1161/ATVBAHA.118.311903.

PMID:
30651003
4.

Diet-Independent Correlations between Bacteria and Dysfunction of Gut, Adipose Tissue, and Liver: A Comprehensive Microbiota Analysis in Feces and Mucosa of the Ileum and Colon in Obese Mice with NAFLD.

Gart E, Souto Lima E, Schuren F, de Ruiter CGF, Attema J, Verschuren L, Keijer J, Salic K, Morrison MC, Kleemann R.

Int J Mol Sci. 2018 Dec 20;20(1). pii: E1. doi: 10.3390/ijms20010001.

5.

Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice.

Morrison MC, Verschuren L, Salic K, Verheij J, Menke A, Wielinga PY, Iruarrizaga-Lejarreta M, Gole L, Yu WM, Turner S, Caspers MPM, Martínez-Arranz I, Pieterman E, Stoop R, van Koppen A, van den Hoek AM, Mato JM, Hanemaaijer R, Alonso C, Kleemann R.

Hepatol Commun. 2018 Oct 29;2(12):1513-1532. doi: 10.1002/hep4.1270. eCollection 2018 Dec.

6.

Extra-Virgin Olive Oil with Natural Phenolic Content Exerts an Anti-Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr-/-.Leiden Mice.

Luque-Sierra A, Alvarez-Amor L, Kleemann R, Martín F, Varela LM.

Mol Nutr Food Res. 2018 Jul;62(13):e1800295. doi: 10.1002/mnfr.201800295. Epub 2018 Jun 12.

PMID:
29763526
7.

Key Inflammatory Processes in Human NASH Are Reflected in Ldlr-/-.Leiden Mice: A Translational Gene Profiling Study.

Morrison MC, Kleemann R, van Koppen A, Hanemaaijer R, Verschuren L.

Front Physiol. 2018 Feb 23;9:132. doi: 10.3389/fphys.2018.00132. eCollection 2018.

8.

Cardiovascular effects among workers exposed to multiwalled carbon nanotubes.

Kuijpers E, Pronk A, Kleemann R, Vlaanderen J, Lan Q, Rothman N, Silverman D, Hoet P, Godderis L, Vermeulen R.

Occup Environ Med. 2018 May;75(5):351-358. doi: 10.1136/oemed-2017-104796. Epub 2018 Feb 10.

PMID:
29440327
9.

CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice.

Zimmer M, Bista P, Benson EL, Lee DY, Liu F, Picarella D, Vega RB, Vu CB, Yeager M, Ding M, Liang G, Horton JD, Kleemann R, Kooistra T, Morrison MC, Wielinga PY, Milne JC, Jirousek MR, Nichols AJ.

Hepatol Commun. 2017 May 12;1(4):311-325. doi: 10.1002/hep4.1042. eCollection 2017 Jun.

10.

LPS-Induced Systemic Inflammation Does Not Alter Atherosclerotic Plaque Area or Inflammation in APOE3*LEIDEN Mice in the Early Phase Up to 15 Days.

Fuijkschot WW, Morrison MC, Zethof IPA, Krijnen PAJ, Kleemann R, Niessen HWM, Smulders YM.

Shock. 2018 Sep;50(3):360-365. doi: 10.1097/SHK.0000000000001026.

PMID:
29023363
11.

Butyrate Reduces HFD-Induced Adipocyte Hypertrophy and Metabolic Risk Factors in Obese LDLr-/-.Leiden Mice.

Pelgrim CE, Franx BAA, Snabel J, Kleemann R, Arnoldussen IAC, Kiliaan AJ.

Nutrients. 2017 Jul 7;9(7). pii: E714. doi: 10.3390/nu9070714.

12.

A casein hydrolysate based formulation attenuates obesity and associated non-alcoholic fatty liver disease and atherosclerosis in LDLr-/-.Leiden mice.

Schoemaker MH, Kleemann R, Morrison MC, Verheij J, Salic K, van Tol EAF, Kooistra T, Wielinga PY.

PLoS One. 2017 Jul 5;12(7):e0180648. doi: 10.1371/journal.pone.0180648. eCollection 2017.

13.

Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21?

Morrison MC, Yakala GK, Liang W, Wielinga PY, Salic K, van Koppen A, Tomar T, Kleemann R, Heeringa P, Kooistra T.

Sci Rep. 2017 Jun 6;7(1):2915. doi: 10.1038/s41598-017-02444-2.

14.

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice.

Zwamborn RA, Slieker RC, Mulder PC, Zoetemelk I, Verschuren L, Suchiman HE, Toet KH, Droog S, Slagboom PE, Kooistra T, Kleemann R, Heijmans BT.

Sci Rep. 2017 Mar 3;7:43261. doi: 10.1038/srep43261.

15.

The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis.

Mulder P, van den Hoek AM, Kleemann R.

PLoS One. 2017 Jan 11;12(1):e0169740. doi: 10.1371/journal.pone.0169740. eCollection 2017.

16.

Orthopedic surgery increases atherosclerotic lesions and necrotic core area in ApoE-/- mice.

Fuijkschot WW, Morrison MC, van der Linden R, Krijnen PAJ, Zethof IPA, Theyse LFH, Kleemann R, Niessen HWM, Smulders YM.

Atherosclerosis. 2016 Dec;255:164-170. doi: 10.1016/j.atherosclerosis.2016.07.909. Epub 2016 Oct 28.

PMID:
27825629
17.

Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice.

Mulder P, Morrison MC, Verschuren L, Liang W, van Bockel JH, Kooistra T, Wielinga PY, Kleemann R.

Sci Rep. 2016 Aug 22;6:31542. doi: 10.1038/srep31542.

18.

Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity.

van der Heijden RA, Morrison MC, Sheedfar F, Mulder P, Schreurs M, Hommelberg PP, Hofker MH, Schalkwijk C, Kleemann R, Tietge UJ, Koonen DP, Heeringa P.

Mediators Inflamm. 2016;2016:2042107. doi: 10.1155/2016/2042107. Epub 2016 Jun 6.

19.

Resolvin E1 attenuates atherosclerosis in absence of cholesterol-lowering effects and on top of atorvastatin.

Salic K, Morrison MC, Verschuren L, Wielinga PY, Wu L, Kleemann R, Gjorstrup P, Kooistra T.

Atherosclerosis. 2016 Jul;250:158-65. doi: 10.1016/j.atherosclerosis.2016.05.001. Epub 2016 May 2.

20.

Early intake of long-chain polyunsaturated fatty acids preserves brain structure and function in diet-induced obesity.

Arnoldussen IA, Zerbi V, Wiesmann M, Noordman RH, Bolijn S, Mutsaers MP, Dederen PJ, Kleemann R, Kooistra T, van Tol EA, Gross G, Schoemaker MH, Heerschap A, Wielinga PY, Kiliaan AJ.

J Nutr Biochem. 2016 Apr;30:177-88. doi: 10.1016/j.jnutbio.2015.12.011. Epub 2016 Jan 21.

PMID:
27012634

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