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Items: 1 to 20 of 85

1.

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signalling and motility in Toxoplasma gondii.

Yang L, Uboldi AD, Seizova S, Wilde ML, Coffey MJ, Katris NJ, Yamaryo-Bottè Y, Kocan M, Bathgate RAD, Stewart RJ, McConville MJ, Thompson PE, Botté CY, Tonkin CJ.

J Biol Chem. 2019 Apr 16. pii: jbc.RA118.005491. doi: 10.1074/jbc.RA118.005491. [Epub ahead of print]

2.

Structural Determinants of Isoform Selectivity in PI3K Inhibitors.

Miller MS, Thompson PE, Gabelli SB.

Biomolecules. 2019 Feb 26;9(3). pii: E82. doi: 10.3390/biom9030082. Review.

3.

Controlled Construction of Cyclic d / l Peptide Nanorods.

Silk MR, Mohanty B, Sampson JB, Scanlon MJ, Thompson PE, Chalmers DK.

Angew Chem Int Ed Engl. 2019 Jan 8;58(2):596-601. doi: 10.1002/anie.201811910. Epub 2018 Dec 5.

PMID:
30452108
4.

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.

Sadek MM, Barlow N, Leung EWW, Williams-Noonan BJ, Yap BK, Shariff FM, Caradoc-Davies TT, Nicholson SE, Chalmers DK, Thompson PE, Law RHP, Norton RS.

ACS Chem Biol. 2018 Oct 19;13(10):2930-2938. doi: 10.1021/acschembio.8b00561. Epub 2018 Sep 18.

PMID:
30226743
5.

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase.

Northfield SE, Wielens J, Headey SJ, Williams-Noonan BJ, Mulcair M, Scanlon MJ, Parker MW, Thompson PE, Chalmers DK.

ChemMedChem. 2018 Aug 10;13(15):1555-1565. doi: 10.1002/cmdc.201800129. Epub 2018 Jul 6.

PMID:
29862651
6.

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.

Velkov T, Gallardo-Godoy A, Swarbrick JD, Blaskovich MAT, Elliott AG, Han M, Thompson PE, Roberts KD, Huang JX, Becker B, Butler MS, Lash LH, Henriques ST, Nation RL, Sivanesan S, Sani MA, Separovic F, Mertens H, Bulach D, Seemann T, Owen J, Li J, Cooper MA.

Cell Chem Biol. 2018 Apr 19;25(4):380-391.e5. doi: 10.1016/j.chembiol.2018.01.005. Epub 2018 Feb 3.

7.

Design and Evaluation of Novel Polymyxin Fluorescent Probes.

Yun B, Roberts KD, Thompson PE, Nation RL, Velkov T, Li J.

Sensors (Basel). 2017 Nov 11;17(11). pii: E2598. doi: 10.3390/s17112598.

8.

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress.

Azad MAK, Sivanesan S, Wang J, Chen K, Nation RL, Thompson PE, Roberts KD, Velkov T, Li J.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01254-17. doi: 10.1128/AAC.01254-17. Print 2018 Jan.

9.

IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model.

Li C, Lev S, Desmarini D, Kaufman-Francis K, Saiardi A, Silva APG, Mackay JP, Thompson PE, Sorrell TC, Djordjevic JT.

Virulence. 2017 Nov 17;8(8):1833-1848. doi: 10.1080/21505594.2017.1385692. Epub 2017 Dec 8.

10.

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation.

Saifuzzaman M, Morrison R, Zheng Z, Orive S, Hamilton J, Thompson PE, Al-Rawi JMA.

Bioorg Med Chem. 2017 Oct 15;25(20):5531-5536. doi: 10.1016/j.bmc.2017.08.022. Epub 2017 Aug 15.

PMID:
28838830
11.

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes.

Han ML, Shen HH, Hansford KA, Schneider EK, Sivanesan S, Roberts KD, Thompson PE, Le Brun AP, Zhu Y, Sani MA, Separovic F, Blaskovich MAT, Baker MA, Moskowitz SM, Cooper MA, Li J, Velkov T.

ACS Infect Dis. 2017 Aug 11;3(8):606-619. doi: 10.1021/acsinfecdis.7b00065. Epub 2017 Jul 11.

12.

Parallel and antiparallel cyclic d/l peptide nanotubes.

Silk MR, Newman J, Ratcliffe JC, White JF, Caradoc-Davies T, Price JR, Perrier S, Thompson PE, Chalmers DK.

Chem Commun (Camb). 2017 Jun 21;53(49):6613-6616. doi: 10.1039/c7cc00846e. Epub 2017 Jun 5.

PMID:
28581562
13.

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.

Galea CA, Han M, Zhu Y, Roberts K, Wang J, Thompson PE, L J, Velkov T.

J Nat Prod. 2017 May 26;80(5):1264-1274. doi: 10.1021/acs.jnatprod.6b00807. Epub 2017 May 2.

PMID:
28463513
14.

Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats.

Sivanesan S, Roberts K, Wang J, Chea SE, Thompson PE, Li J, Nation RL, Velkov T.

J Nat Prod. 2017 Jan 27;80(1):225-229. doi: 10.1021/acs.jnatprod.6b01176. Epub 2017 Jan 12.

PMID:
28080060
15.

Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase.

Galea CA, Roberts KD, Zhu Y, Thompson PE, Li J, Velkov T.

Biochemistry. 2017 Jan 31;56(4):657-668. doi: 10.1021/acs.biochem.6b01139. Epub 2017 Jan 17.

PMID:
28071053
16.

Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity.

Morrison R, Zheng Z, Jennings IG, Thompson PE, Al-Rawi JMA.

Bioorg Med Chem Lett. 2016 Nov 15;26(22):5534-5538. doi: 10.1016/j.bmcl.2016.10.003. Epub 2016 Oct 5.

PMID:
27765510
17.

Class II Phosphoinositide 3-Kinases as Novel Drug Targets.

Falasca M, Hamilton JR, Selvadurai M, Sundaram K, Adamska A, Thompson PE.

J Med Chem. 2017 Jan 12;60(1):47-65. doi: 10.1021/acs.jmedchem.6b00963. Epub 2016 Oct 21. Review.

PMID:
27644332
18.

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes.

Velkov T, Yun B, Schneider EK, Azad MA, Dolezal O, Morris FC, Nation RL, Wang J, Chen K, Yu HH, Wang L, Thompson PE, Roberts KD, Li J.

ACS Infect Dis. 2016 May 13;2(5):341-51. doi: 10.1021/acsinfecdis.6b00031. Epub 2016 Mar 29.

19.

Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ.

Miller MS, Mountford SJ, Pinson JA, Zheng Z, Künzli M, Patel V, Hogg SJ, Shortt J, Jennings IG, Thompson PE.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4790-4794. doi: 10.1016/j.bmcl.2016.08.028. Epub 2016 Aug 11.

PMID:
27561716
20.

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria.

Roberts KD, Azad MA, Wang J, Horne AS, Thompson PE, Nation RL, Velkov T, Li J.

ACS Infect Dis. 2015 Nov 13;1(11):568-575. Epub 2015 Sep 4.

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