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Methyl DNA Phosphate Adduct Formation in Lung Tumor Tissue and Adjacent Normal Tissue of Lung Cancer Patients.

Ma B, Villalta PW, Hochalter JB, Stepanov I, Hecht SS.

Carcinogenesis. 2019 Mar 12. pii: bgz053. doi: 10.1093/carcin/bgz053. [Epub ahead of print]


The human gut bacterial genotoxin colibactin alkylates DNA.

Wilson MR, Jiang Y, Villalta PW, Stornetta A, Boudreau PD, Carrá A, Brennan CA, Chun E, Ngo L, Samson LD, Engelward BP, Garrett WS, Balbo S, Balskus EP.

Science. 2019 Feb 15;363(6428). pii: eaar7785. doi: 10.1126/science.aar7785.


Analysis of Acrolein-Derived 1, N2-Propanodeoxyguanosine Adducts in Human Lung DNA from Smokers and Nonsmokers.

Yang J, Balbo S, Villalta PW, Hecht SS.

Chem Res Toxicol. 2019 Feb 18;32(2):318-325. doi: 10.1021/acs.chemrestox.8b00326. Epub 2019 Jan 30.


Targeted and Untargeted Detection of DNA Adducts of Aromatic Amine Carcinogens in Human Bladder by Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry.

Guo J, Villalta PW, Weight CJ, Bonala R, Johnson F, Rosenquist TA, Turesky RJ.

Chem Res Toxicol. 2018 Dec 17;31(12):1382-1397. doi: 10.1021/acs.chemrestox.8b00268. Epub 2018 Nov 19.


In Vivo Stable-Isotope Labeling and Mass-Spectrometry-Based Metabolic Profiling of a Potent Tobacco-Specific Carcinogen in Rats.

Dator R, von Weymarn LB, Villalta PW, Hooyman CJ, Maertens LA, Upadhyaya P, Murphy SE, Balbo S.

Anal Chem. 2018 Oct 16;90(20):11863-11872. doi: 10.1021/acs.analchem.8b01881. Epub 2018 Oct 4.


Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.

Carcinogenesis. 2018 Feb 9;39(2):232-241. doi: 10.1093/carcin/bgx135.


Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.

Chem Res Toxicol. 2018 Jan 16;31(1):48-57. doi: 10.1021/acs.chemrestox.7b00281. Epub 2017 Nov 30.


Ultrasensitive High-Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung.

Villalta PW, Hochalter JB, Hecht SS.

Anal Chem. 2017 Dec 5;89(23):12735-12742. doi: 10.1021/acs.analchem.7b02856. Epub 2017 Nov 17.


Data-Independent Mass Spectrometry Approach for Screening and Identification of DNA Adducts.

Guo J, Villalta PW, Turesky RJ.

Anal Chem. 2017 Nov 7;89(21):11728-11736. doi: 10.1021/acs.analchem.7b03208. Epub 2017 Oct 18.


Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon.

Cheng G, Zarth AT, Upadhyaya P, Villalta PW, Balbo S, Hecht SS.

Chem Biol Interact. 2017 Aug 25;274:80-88. doi: 10.1016/j.cbi.2017.07.005. Epub 2017 Jul 8.


Mass Spectrometry Based Proteomics Study of Cisplatin-Induced DNA-Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells.

Ming X, Groehler A 4th, Michaelson-Richie ED, Villalta PW, Campbell C, Tretyakova NY.

Chem Res Toxicol. 2017 Apr 17;30(4):980-995. doi: 10.1021/acs.chemrestox.6b00389. Epub 2017 Mar 29.


DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A.

Stornetta A, Villalta PW, Gossner F, Wilson WR, Balbo S, Sturla SJ.

Chem Res Toxicol. 2017 Mar 20;30(3):830-839. doi: 10.1021/acs.chemrestox.6b00412. Epub 2017 Feb 19.


Biomonitoring DNA Adducts of Cooked Meat Carcinogens in Human Prostate by Nano Liquid Chromatography-High Resolution Tandem Mass Spectrometry: Identification of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA Adduct.

Xiao S, Guo J, Yun BH, Villalta PW, Krishna S, Tejpaul R, Murugan P, Weight CJ, Turesky RJ.

Anal Chem. 2016 Dec 20;88(24):12508-12515. doi: 10.1021/acs.analchem.6b04157. Epub 2016 Dec 1.


Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.

Widen JC, Kempema AM, Villalta PW, Harki DA.

ACS Chem Biol. 2017 Jan 20;12(1):102-113. doi: 10.1021/acschembio.6b00751. Epub 2016 Nov 28.


Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Albumin in Humans.

Wang Y, Villalta PW, Peng L, Dingley K, Malfatti MA, Turteltaub KW, Turesky RJ.

Chem Res Toxicol. 2017 Feb 20;30(2):705-714. doi: 10.1021/acs.chemrestox.6b00426. Epub 2017 Jan 18.


A High Resolution/Accurate Mass (HRAM) Data-Dependent MS3 Neutral Loss Screening, Classification, and Relative Quantitation Methodology for Carbonyl Compounds in Saliva.

Dator R, Carrà A, Maertens L, Guidolin V, Villalta PW, Balbo S.

J Am Soc Mass Spectrom. 2017 Apr;28(4):608-618. doi: 10.1007/s13361-016-1521-y. Epub 2016 Oct 26.


Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in human retinal DNA by liquid chromatography nanoelectrospray-tandem mass spectrometry.

Ma B, Jing M, Villalta PW, Kapphahn RJ, Montezuma SR, Ferrington DA, Stepanov I.

Sci Rep. 2016 Mar 16;6:22375. doi: 10.1038/srep22375.


Covalent DNA-Protein Cross-Linking by Phosphoramide Mustard and Nornitrogen Mustard in Human Cells.

Groehler A 4th, Villalta PW, Campbell C, Tretyakova N.

Chem Res Toxicol. 2016 Feb 15;29(2):190-202. doi: 10.1021/acs.chemrestox.5b00430. Epub 2016 Jan 20.

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