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Items: 1 to 20 of 34

1.

SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent.

Borsari C, Santarem N, Macedo S, Jiménez-Antón MD, Torrado JJ, Olías-Molero AI, Corral MJ, Tait A, Ferrari S, Costantino L, Luciani R, Ponterini G, Gul S, Kuzikov M, Ellinger B, Behrens B, Reinshagen J, Alunda JM, Cordeiro-da-Silva A, Costi MP.

ACS Med Chem Lett. 2019 Jan 29;10(4):528-533. doi: 10.1021/acsmedchemlett.8b00565. eCollection 2019 Apr 11.

PMID:
30996791
2.

Quantification of Leishmania Parasites in Murine Models of Visceral Infection.

Tavares J, Santarém N, Cordeiro-da-Silva A.

Methods Mol Biol. 2019;1971:289-301. doi: 10.1007/978-1-4939-9210-2_16.

PMID:
30980311
3.

In Vitro Infections of Macrophage-Like Cell Lines with Leishmania infantum for Drug Screening.

Santarém N, Tavares J, Cordeiro-da-Silva A.

Methods Mol Biol. 2019;1971:265-277. doi: 10.1007/978-1-4939-9210-2_14.

PMID:
30980309
4.

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.

Linciano P, Pozzi C, Iacono LD, di Pisa F, Landi G, Bonucci A, Gul S, Kuzikov M, Ellinger B, Witt G, Santarem N, Baptista C, Franco C, Moraes CB, Müller W, Wittig U, Luciani R, Sesenna A, Quotadamo A, Ferrari S, Pöhner I, Cordeiro-da-Silva A, Mangani S, Costantino L, Costi MP.

J Med Chem. 2019 Apr 25;62(8):3989-4012. doi: 10.1021/acs.jmedchem.8b02021. Epub 2019 Apr 9.

PMID:
30908048
5.

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.

Moraes CB, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis KC, Mangani S, Di Pisa F, Landi G, Iacono LD, Pozzi C, Freitas-Junior LH, Dos Santos Pascoalino B, Bertolacini CP, Behrens B, Keminer O, Leu J, Wolf M, Reinshagen J, Cordeiro-da-Silva A, Santarem N, Venturelli A, Wrigley S, Karunakaran D, Kebede B, Pöhner I, Müller W, Panecka-Hofman J, Wade RC, Fenske M, Clos J, Alunda JM, Corral MJ, Uliassi E, Bolognesi ML, Linciano P, Quotadamo A, Ferrari S, Santucci M, Borsari C, Costi MP, Gul S.

SLAS Discov. 2019 Mar;24(3):346-361. doi: 10.1177/2472555218823171.

PMID:
30784368
6.

More than just exosomes: distinct Leishmania infantum extracellular products potentiate the establishment of infection.

Pérez-Cabezas B, Santarém N, Cecílio P, Silva C, Silvestre R, A M Catita J, Cordeiro da Silva A.

J Extracell Vesicles. 2018 Nov 8;8(1):1541708. doi: 10.1080/20013078.2018.1541708. eCollection 2019.

7.

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.

Linciano P, Moraes CB, Alcantara LM, Franco CH, Pascoalino B, Freitas-Junior LH, Macedo S, Santarem N, Cordeiro-da-Silva A, Gul S, Witt G, Kuzikov M, Ellinger B, Ferrari S, Luciani R, Quotadamo A, Costantino L, Costi MP.

Eur J Med Chem. 2018 Feb 25;146:423-434. doi: 10.1016/j.ejmech.2018.01.043. Epub 2018 Jan 31.

PMID:
29407968
8.

Potential Drug Targets in the Pentose Phosphate Pathway of Trypanosomatids.

Loureiro I, Faria J, Santarem N, Smith TK, Tavares J, Cordeiro-da-Silva A.

Curr Med Chem. 2018;25(39):5239-5265. doi: 10.2174/0929867325666171206094752. Review.

PMID:
29210635
9.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

Linciano P, Dawson A, Pöhner I, Costa DM, Sá MS, Cordeiro-da-Silva A, Luciani R, Gul S, Witt G, Ellinger B, Kuzikov M, Gribbon P, Reinshagen J, Wolf M, Behrens B, Hannaert V, Michels PAM, Nerini E, Pozzi C, di Pisa F, Landi G, Santarem N, Ferrari S, Saxena P, Lazzari S, Cannazza G, Freitas-Junior LH, Moraes CB, Pascoalino BS, Alcântara LM, Bertolacini CP, Fontana V, Wittig U, Müller W, Wade RC, Hunter WN, Mangani S, Costantino L, Costi MP.

ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11.

10.

Leishmania infantum Exoproducts Inhibit Human Invariant NKT Cell Expansion and Activation.

Belo R, Santarém N, Pereira C, Pérez-Cabezas B, Macedo F, Leite-de-Moraes M, Cordeiro-da-Silva A.

Front Immunol. 2017 Jun 19;8:710. doi: 10.3389/fimmu.2017.00710. eCollection 2017.

11.

The use of Escherichia coli total antigens as a complementary approach to address seropositivity to Leishmania antigens in canine leishmaniosis.

Lima C, Mesquita JR, Brancal H, Vahlenkamp T, Teixeira AR, Cardoso L, Amorim C, Santarém N, DA Silva AC.

Parasitology. 2017 Sep;144(10):1384-1393. doi: 10.1017/S0031182017000713. Epub 2017 May 23.

PMID:
28534448
12.

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.

Di Pisa F, Landi G, Dello Iacono L, Pozzi C, Borsari C, Ferrari S, Santucci M, Santarem N, Cordeiro-da-Silva A, Moraes CB, Alcantara LM, Fontana V, Freitas-Junior LH, Gul S, Kuzikov M, Behrens B, Pöhner I, Wade RC, Costi MP, Mangani S.

Molecules. 2017 Mar 8;22(3). pii: E426. doi: 10.3390/molecules22030426.

13.

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.

Borsari C, Santarem N, Torrado J, Olías AI, Corral MJ, Baptista C, Gul S, Wolf M, Kuzikov M, Ellinger B, Witt G, Gribbon P, Reinshagen J, Linciano P, Tait A, Costantino L, Freitas-Junior LH, Moraes CB, Bruno Dos Santos P, Alcântara LM, Franco CH, Bertolacini CD, Fontana V, Tejera Nevado P, Clos J, Alunda JM, Cordeiro-da-Silva A, Ferrari S, Costi MP.

Eur J Med Chem. 2017 Jan 27;126:1129-1135. doi: 10.1016/j.ejmech.2016.12.017. Epub 2016 Dec 9.

PMID:
28064141
14.

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

Borsari C, Luciani R, Pozzi C, Poehner I, Henrich S, Trande M, Cordeiro-da-Silva A, Santarem N, Baptista C, Tait A, Di Pisa F, Dello Iacono L, Landi G, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Gribbon P, Kohler M, Keminer O, Behrens B, Costantino L, Tejera Nevado P, Bifeld E, Eick J, Clos J, Torrado J, Jiménez-Antón MD, Corral MJ, Alunda JM, Pellati F, Wade RC, Ferrari S, Mangani S, Costi MP.

J Med Chem. 2016 Aug 25;59(16):7598-616. doi: 10.1021/acs.jmedchem.6b00698. Epub 2016 Aug 5.

PMID:
27411733
15.

Disclosing the essentiality of ribose-5-phosphate isomerase B in Trypanosomatids.

Faria J, Loureiro I, Santarém N, Cecílio P, Macedo-Ribeiro S, Tavares J, Cordeiro-da-Silva A.

Sci Rep. 2016 May 27;6:26937. doi: 10.1038/srep26937.

16.

Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity.

Faria J, Loureiro I, Santarém N, Macedo-Ribeiro S, Tavares J, Cordeiro-da-Silva A.

PLoS Negl Trop Dis. 2016 Jan 15;10(1):e0004365. doi: 10.1371/journal.pntd.0004365. eCollection 2016 Jan.

17.

Ribose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivity.

Loureiro I, Faria J, Clayton C, Macedo-Ribeiro S, Santarém N, Roy N, Cordeiro-da-Siva A, Tavares J.

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3430. doi: 10.1371/journal.pntd.0003430. eCollection 2015 Jan.

18.

Deception and manipulation: the arms of leishmania, a successful parasite.

Cecílio P, Pérez-Cabezas B, Santarém N, Maciel J, Rodrigues V, Cordeiro da Silva A.

Front Immunol. 2014 Oct 20;5:480. doi: 10.3389/fimmu.2014.00480. eCollection 2014. Review.

19.

Cutaneous leishmaniosis in a horse from northern Portugal.

Gama A, Elias J, Ribeiro AJ, Alegria N, Schallig HD, Silva F, Santarém N, Cardoso L, Cotovio M.

Vet Parasitol. 2014 Feb 24;200(1-2):189-92. doi: 10.1016/j.vetpar.2013.12.005. Epub 2013 Dec 14.

PMID:
24388338
20.

Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine.

Loureiro I, Faria J, Clayton C, Ribeiro SM, Roy N, Santarém N, Tavares J, Cordeiro-da-Silva A.

PLoS Negl Trop Dis. 2013 Dec 5;7(12):e2578. doi: 10.1371/journal.pntd.0002578. eCollection 2013. Erratum in: PLoS Negl Trop Dis. 2013;7(12). doi:10.1371/annotation/eb4faa32-fc8d-43ae-ba92-f34c0c4e5052.

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