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Items: 1 to 20 of 173

1.

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines.

Hirano K, Gondo S, Punna N, Tokunaga E, Shibata N.

ChemistryOpen. 2019 Feb 5;8(4):406-410. doi: 10.1002/open.201800286. eCollection 2019 Apr.

2.

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines.

Hirano K, Gondo S, Punna N, Tokunaga E, Shibata N.

ChemistryOpen. 2019 Mar 12;8(4):402. doi: 10.1002/open.201900070. eCollection 2019 Apr.

3.

Pd-Catalyzed Decarboxylative Cyclization of Trifluoromethyl Vinyl Benzoxazinanones with Sulfur Ylides: Access to Trifluoromethyl Dihydroquinolines.

Punna N, Harada K, Zhou J, Shibata N.

Org Lett. 2019 Mar 1;21(5):1515-1520. doi: 10.1021/acs.orglett.9b00330. Epub 2019 Feb 21.

PMID:
30789742
4.

Asymmetric Electrophilic Difluoromethylthiolation of Indanone-Based β-Keto Esters Using Difluoromethanesulfonyl Hypervalent Iodonium Ylides.

Gondo S, Matsubara O, Chachignon H, Sumii Y, Cahard D, Shibata N.

Molecules. 2019 Jan 9;24(2). pii: E221. doi: 10.3390/molecules24020221.

5.

Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers.

Tokunaga E, Yamamoto T, Ito E, Shibata N.

Sci Rep. 2018 Nov 20;8(1):17131. doi: 10.1038/s41598-018-35457-6.

6.

Synthesis of Chiral Nonracemic α-Difluoromethylthio Compounds with Tetrasubstituted Stereogenic Centers via a Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation.

Kondo H, Maeno M, Sasaki K, Guo M, Hashimoto M, Shiro M, Shibata N.

Org Lett. 2018 Nov 16;20(22):7044-7048. doi: 10.1021/acs.orglett.8b02998. Epub 2018 Nov 8.

PMID:
30407832
7.

Defluorosilylation of fluoroarenes and fluoroalkanes.

Cui B, Jia S, Tokunaga E, Shibata N.

Nat Commun. 2018 Oct 22;9(1):4393. doi: 10.1038/s41467-018-06830-w.

8.

Design and synthesis of galactose-conjugated fluorinated and non-fluorinated proline oligomers: towards antifreeze molecules.

Sumii Y, Hibino H, Saidalimu I, Kawahara H, Shibata N.

Chem Commun (Camb). 2018 Aug 28;54(70):9749-9752. doi: 10.1039/c8cc05588b.

PMID:
30102305
9.
10.

Highly C-selective difluoromethylation of β-ketoesters by using TMSCF2Br/lithium hydroxide/N,N,N-trimethylhexadecan-1-ammonium bromide.

Wang J, Tokunaga E, Shibata N.

Chem Commun (Camb). 2018 Aug 7;54(64):8881-8884. doi: 10.1039/c8cc05135f.

PMID:
30043773
11.

The CF3-DAST-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones/lactams/lactones and its extension to deacylative pentafluorophenylthiolation.

Saidalimu I, Yoshioka T, Liang Y, Tokunaga E, Shibata N.

Chem Commun (Camb). 2018 Aug 2;54(63):8761-8764. doi: 10.1039/c8cc05409f.

PMID:
30033470
12.

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.

Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, Nakamura S, Nakagawa H, Ikeda SI, Umezawa N, Kato N, Yokoshima S, Shibuya M, Shimonishi M, Kojima H, Okabe T, Nagano T, Naguro I, Imamura K, Inoue H, Fujisawa T, Ichijo H.

Nat Commun. 2018 Jul 10;9(1):2668. doi: 10.1038/s41467-018-05127-2.

13.

An eccentric rod-like linear connection of two heterocycles: synthesis of pyridine trans-tetrafluoro-λ6-sulfanyl triazoles.

Das P, Niina K, Hiromura T, Tokunaga E, Saito N, Shibata N.

Chem Sci. 2018 May 14;9(22):4931-4936. doi: 10.1039/c8sc01216d. eCollection 2018 Jun 14.

14.

Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes.

Punna N, Harada K, Shibata N.

Chem Commun (Camb). 2018 Jun 26;54(52):7171-7174. doi: 10.1039/c8cc03541e.

PMID:
29888364
15.
16.

Access to benzo-fused nine-membered heterocyclic alkenes with a trifluoromethyl carbinol moiety via a double decarboxylative formal ring-expansion process under palladium catalysis.

Das P, Gondo S, Nagender P, Uno H, Tokunaga E, Shibata N.

Chem Sci. 2018 Feb 23;9(13):3276-3281. doi: 10.1039/c7sc05447e. eCollection 2018 Apr 7.

17.

Stereodivergent trifluoromethylation of N-sulfinylimines by fluoroform with either organic-superbase or organometallic-base.

Punna N, Saito T, Kosobokov M, Tokunaga E, Sumii Y, Shibata N.

Chem Commun (Camb). 2018 Apr 24;54(34):4294-4297. doi: 10.1039/c8cc01526k.

PMID:
29632907
18.

Modern Approaches for Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs.

Zhu Y, Han J, Wang J, Shibata N, Sodeoka M, Soloshonok VA, Coelho JAS, Toste FD.

Chem Rev. 2018 Apr 11;118(7):3887-3964. doi: 10.1021/acs.chemrev.7b00778. Epub 2018 Apr 2.

19.

Synthesis of fluoro-functionalized diaryl-λ3-iodonium salts and their cytotoxicity against human lymphoma U937 cells.

Das P, Tokunaga E, Akiyama H, Doi H, Saito N, Shibata N.

Beilstein J Org Chem. 2018 Feb 7;14:364-372. doi: 10.3762/bjoc.14.24. eCollection 2018.

20.

Synthesis of Aryl Triflones through the Trifluoromethanesulfonylation of Benzynes.

Sumii Y, Sugita Y, Tokunaga E, Shibata N.

ChemistryOpen. 2018 Feb 27;7(2):204-211. doi: 10.1002/open.201700204. eCollection 2018 Feb.

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