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Peptide Mimics of the Ribosomal P Stalk Inhibit the Activity of Ricin A Chain by Preventing Ribosome Binding.

Li XP, Kahn JN, Tumer NE.

Toxins (Basel). 2018 Sep 13;10(9). pii: E371. doi: 10.3390/toxins10090371.


Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins.

Zhou Y, Li XP, Kahn JN, Tumer NE.

Toxins (Basel). 2018 Jun 14;10(6). pii: E240. doi: 10.3390/toxins10060240. Review.


Human ribosomal P1-P2 heterodimer represents an optimal docking site for ricin A chain with a prominent role for P1 C-terminus.

Grela P, Li XP, Horbowicz P, Dźwierzyńska M, Tchórzewski M, Tumer NE.

Sci Rep. 2017 Jul 17;7(1):5608. doi: 10.1038/s41598-017-05675-5.


Differences in Ribosome Binding and Sarcin/Ricin Loop Depurination by Shiga and Ricin Holotoxins.

Li XP, Tumer NE.

Toxins (Basel). 2017 Apr 11;9(4). pii: E133. doi: 10.3390/toxins9040133. Erratum in: Toxins (Basel). 2018 Mar 01;10(3):.


Ricin uses arginine 235 as an anchor residue to bind to P-proteins of the ribosomal stalk.

Zhou Y, Li XP, Chen BY, Tumer NE.

Sci Rep. 2017 Feb 23;7:42912. doi: 10.1038/srep42912.


Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome.

Jetzt AE, Li XP, Tumer NE, Cohick WS.

Toxicol Appl Pharmacol. 2016 Nov 1;310:120-128. doi: 10.1016/j.taap.2016.09.004. Epub 2016 Sep 15.


Introduction to the toxins special issue on plant toxins.

Tumer NE.

Toxins (Basel). 2015 Nov;7(11):4503-6. doi: 10.3390/toxins7114503. No abstract available.


The A1 Subunit of Shiga Toxin 2 Has Higher Affinity for Ribosomes and Higher Catalytic Activity than the A1 Subunit of Shiga Toxin 1.

Basu D, Li XP, Kahn JN, May KL, Kahn PC, Tumer NE.

Infect Immun. 2015 Oct 19;84(1):149-61. doi: 10.1128/IAI.00994-15. Print 2016 Jan.


A Lipid Transfer Protein Increases the Glutathione Content and Enhances Arabidopsis Resistance to a Trichothecene Mycotoxin.

McLaughlin JE, Bin-Umer MA, Widiez T, Finn D, McCormick S, Tumer NE.

PLoS One. 2015 Jun 9;10(6):e0130204. doi: 10.1371/journal.pone.0130204. eCollection 2015.


Do the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2?

Basu D, Tumer NE.

Toxins (Basel). 2015 Apr 29;7(5):1467-85. doi: 10.3390/toxins7051467. Review.


Pokeweed antiviral protein: its cytotoxicity mechanism and applications in plant disease resistance.

Di R, Tumer NE.

Toxins (Basel). 2015 Mar 6;7(3):755-72. doi: 10.3390/toxins7030755. Review.


Arabidopsis Bax Inhibitor-1 inhibits cell death induced by pokeweed antiviral protein in Saccharomyces cerevisiae.

Çakır B, Tumer NE.

Microb Cell. 2015 Feb 2;2(2):43-56. doi: 10.15698/mic2015.02.190.


Wild type RTA and less toxic variants have distinct requirements for Png1 for their depurination activity and toxicity in Saccharomyces cerevisiae.

Yan Q, Li XP, Tumer NE.

PLoS One. 2014 Dec 1;9(12):e113719. doi: 10.1371/journal.pone.0113719. eCollection 2014.


Elimination of damaged mitochondria through mitophagy reduces mitochondrial oxidative stress and increases tolerance to trichothecenes.

Bin-Umer MA, McLaughlin JE, Butterly MS, McCormick S, Tumer NE.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11798-803. doi: 10.1073/pnas.1403145111. Epub 2014 Jul 28.


Functional divergence between the two P1-P2 stalk dimers on the ribosome in their interaction with ricin A chain.

Grela P, Li XP, Tchórzewski M, Tumer NE.

Biochem J. 2014 May 15;460(1):59-67. doi: 10.1042/BJ20140014.


Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Li XP, Kahn PC, Kahn JN, Grela P, Tumer NE.

J Biol Chem. 2013 Oct 18;288(42):30270-84. doi: 10.1074/jbc.M113.510966. Epub 2013 Sep 3.


Targeting ricin to the ribosome.

May KL, Yan Q, Tumer NE.

Toxicon. 2013 Jul;69:143-51. doi: 10.1016/j.toxicon.2013.02.001. Epub 2013 Feb 20. Review.

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