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A Triple Amino Acid Substitution at Position 88/94/95 in Glycoprotein GP2a of Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV1) Is Responsible for Adaptation to MARC-145 Cells.

Xie J, Trus I, Oh D, Kvisgaard LK, Rappe JCF, Ruggli N, Vanderheijden N, Larsen LE, Lefèvre F, Nauwynck HJ.

Viruses. 2019 Jan 8;11(1). pii: E36. doi: 10.3390/v11010036.


Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids.

Englezou PC, Sapet C, Démoulins T, Milona P, Ebensen T, Schulze K, Guzman CA, Poulhes F, Zelphati O, Ruggli N, McCullough KC.

Mol Ther Nucleic Acids. 2018 Sep 7;12:118-134. doi: 10.1016/j.omtn.2018.04.019. Epub 2018 May 4.


Antiviral activity of K22 against members of the order Nidovirales.

Rappe JCF, de Wilde A, Di H, Müller C, Stalder H, V'kovski P, Snijder E, Brinton MA, Ziebuhr J, Ruggli N, Thiel V.

Virus Res. 2018 Feb 15;246:28-34. doi: 10.1016/j.virusres.2018.01.002. Epub 2018 Jan 11.


Virus replicon particle vaccines expressing nucleoprotein of influenza A virus mediate enhanced inflammatory responses in pigs.

Ricklin ME, Python S, Vielle NJ, Brechbühl D, Zumkehr B, Posthaus H, Zimmer G, Ruggli N, Summerfield A.

Sci Rep. 2017 Nov 27;7(1):16379. doi: 10.1038/s41598-017-16419-w.


Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure.

Démoulins T, Ebensen T, Schulze K, Englezou PC, Pelliccia M, Guzmán CA, Ruggli N, McCullough KC.

J Control Release. 2017 Nov 28;266:256-271. doi: 10.1016/j.jconrel.2017.09.018. Epub 2017 Sep 19.


Novel poly-uridine insertion in the 3'UTR and E2 amino acid substitutions in a low virulent classical swine fever virus.

Coronado L, Liniger M, Muñoz-González S, Postel A, Pérez LJ, Pérez-Simó M, Perera CL, Frías-Lepoureau MT, Rosell R, Grundhoff A, Indenbirken D, Alawi M, Fischer N, Becher P, Ruggli N, Ganges L.

Vet Microbiol. 2017 Mar;201:103-112. doi: 10.1016/j.vetmic.2017.01.013. Epub 2017 Jan 17.


Self-Replicating RNA Vaccine Delivery to Dendritic Cells.

Démoulins T, Englezou PC, Milona P, Ruggli N, Tirelli N, Pichon C, Sapet C, Ebensen T, Guzmán CA, McCullough KC.

Methods Mol Biol. 2017;1499:37-75. Review.


Heterogeneous antigenic properties of the porcine reproductive and respiratory syndrome virus nucleocapsid.

Rappe JC, García-Nicolás O, Flückiger F, Thür B, Hofmann MA, Summerfield A, Ruggli N.

Vet Res. 2016 Nov 21;47(1):117.


Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences.

Auray G, Keller I, Python S, Gerber M, Bruggmann R, Ruggli N, Summerfield A.

J Immunol. 2016 Dec 15;197(12):4791-4806. Epub 2016 Nov 11.


Sensing of Porcine Reproductive and Respiratory Syndrome Virus-Infected Macrophages by Plasmacytoid Dendritic Cells.

García-Nicolás O, Auray G, Sautter CA, Rappe JC, McCullough KC, Ruggli N, Summerfield A.

Front Microbiol. 2016 Jun 2;7:771. doi: 10.3389/fmicb.2016.00771. eCollection 2016.


Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer.

Gottipati K, Holthauzen LM, Ruggli N, Choi KH.

J Virol. 2016 Aug 12;90(17):7740-7. doi: 10.1128/JVI.00318-16. Print 2016 Sep 1.


Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model.

Bolz M, Ruggli N, Borel N, Pluschke G, Ruf MT.

PLoS Negl Trop Dis. 2016 Apr 29;10(4):e0004678. doi: 10.1371/journal.pntd.0004678. eCollection 2016 Apr.


A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration.

Scheel TK, Luna JM, Liniger M, Nishiuchi E, Rozen-Gagnon K, Shlomai A, Auray G, Gerber M, Fak J, Keller I, Bruggmann R, Darnell RB, Ruggli N, Rice CM.

Cell Host Microbe. 2016 Mar 9;19(3):409-23. doi: 10.1016/j.chom.2016.02.007.


Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs.

Eck M, Durán MG, Ricklin ME, Locher S, Sarraseca J, Rodríguez MJ, McCullough KC, Summerfield A, Zimmer G, Ruggli N.

Vet Res. 2016 Feb 19;47:33. doi: 10.1186/s13567-016-0318-0.


Immune Responses Against Classical Swine Fever Virus: Between Ignorance and Lunacy.

Summerfield A, Ruggli N.

Front Vet Sci. 2015 May 7;2:10. doi: 10.3389/fvets.2015.00010. eCollection 2015. Review.


Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines.

Démoulins T, Milona P, Englezou PC, Ebensen T, Schulze K, Suter R, Pichon C, Midoux P, Guzmán CA, Ruggli N, McCullough KC.

Nanomedicine. 2016 Apr;12(3):711-722. doi: 10.1016/j.nano.2015.11.001. Epub 2015 Dec 1.


Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs.

Muñoz-González S, Perez-Simó M, Muñoz M, Bohorquez JA, Rosell R, Summerfield A, Domingo M, Ruggli N, Ganges L.

Vet Res. 2015 Jul 9;46:78. doi: 10.1186/s13567-015-0209-9.


Intracellular membrane association of the N-terminal domain of classical swine fever virus NS4B determines viral genome replication and virulence.

Tamura T, Ruggli N, Nagashima N, Okamatsu M, Igarashi M, Mine J, Hofmann MA, Liniger M, Summerfield A, Kida H, Sakoda Y.

J Gen Virol. 2015 Sep;96(9):2623-35. doi: 10.1099/vir.0.000200. Epub 2015 May 26.


Postnatal persistent infection with classical Swine Fever virus and its immunological implications.

Muñoz-González S, Ruggli N, Rosell R, Pérez LJ, Frías-Leuporeau MT, Fraile L, Montoya M, Cordoba L, Domingo M, Ehrensperger F, Summerfield A, Ganges L.

PLoS One. 2015 May 4;10(5):e0125692. doi: 10.1371/journal.pone.0125692. eCollection 2015.


The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production.

Mine J, Tamura T, Mitsuhashi K, Okamatsu M, Parchariyanon S, Pinyochon W, Ruggli N, Tratschin JD, Kida H, Sakoda Y.

J Gen Virol. 2015 Jul;96(Pt 7):1746-56. doi: 10.1099/vir.0.000132. Epub 2015 Mar 25.


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