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Items: 1 to 20 of 30


Benzo[d]thiazol-2(3H)-ones as new potent selective CB2 agonists with anti-inflammatory properties.

Leleu-Chavain N, Baudelet D, Heloire VM, Rocha DE, Renault N, Barczyk A, Djouina M, Body-Malapel M, Carato P, Millet R.

Eur J Med Chem. 2019 Mar 1;165:347-362. doi: 10.1016/j.ejmech.2018.12.008. Epub 2018 Dec 13.


A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.

Gay M, Evrard C, Descamps F, Carato P, Renault N, Coevoet M, Eddarkaoui S, Baud C, Larchanché PE, Buée L, El Bakali J, Vingtdeux V, Sergeant N, Melnyk P.

Eur J Med Chem. 2018 Nov 5;159:104-125. doi: 10.1016/j.ejmech.2018.08.092. Epub 2018 Sep 22.


Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure.

Boulahjar R, Rincon Arias A, Bolteau R, Renault N, Coevoet M, Barczyk A, Duroux R, Yous S, Melnyk P, Agouridas L.

Bioorg Med Chem. 2018 Jul 23;26(12):3296-3307. doi: 10.1016/j.bmc.2018.04.057. Epub 2018 Apr 30.


Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

Gibault F, Coevoet M, Sturbaut M, Farce A, Renault N, Allemand F, Guichou JF, Drucbert AS, Foulon C, Magnez R, Thuru X, Corvaisier M, Huet G, Chavatte P, Melnyk P, Bailly F, Cotelle P.

Cancers (Basel). 2018 May 8;10(5). pii: E140. doi: 10.3390/cancers10050140.


New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.

Gay M, Carato P, Coevoet M, Renault N, Larchanché PE, Barczyk A, Yous S, Buée L, Sergeant N, Melnyk P.

Bioorg Med Chem. 2018 May 1;26(8):2151-2164. doi: 10.1016/j.bmc.2018.03.016. Epub 2018 Mar 12.


Antagonists of the adenosine A2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity.

Duroux R, Agouridas L, Renault N, El Bakali J, Furman C, Melnyk P, Yous S.

Eur J Med Chem. 2018 Jan 20;144:151-163. doi: 10.1016/j.ejmech.2017.12.007. Epub 2017 Dec 5.


Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50.

Clement N, Renault N, Guillaume JL, Cecon E, Journé AS, Laurent X, Tadagaki K, Cogé F, Gohier A, Delagrange P, Chavatte P, Jockers R.

Br J Pharmacol. 2018 Aug;175(16):3281-3297. doi: 10.1111/bph.14029. Epub 2017 Oct 27.


Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor.

Duroux R, Renault N, Cuelho JE, Agouridas L, Blum D, Lopes LV, Melnyk P, Yous S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):850-864. doi: 10.1080/14756366.2017.1334648.


Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity.

Segaoula Z, Leclercq J, Verones V, Flouquet N, Lecoeur M, Ach L, Renault N, Barczyk A, Melnyk P, Berthelot P, Thuru X, Lebegue N.

J Med Chem. 2016 Sep 22;59(18):8422-40. doi: 10.1021/acs.jmedchem.6b00847. Epub 2016 Aug 30.


Update on melatonin receptors: IUPHAR Review 20.

Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP.

Br J Pharmacol. 2016 Sep;173(18):2702-25. doi: 10.1111/bph.13536. Epub 2016 Aug 8. Review.


Design, synthesis and biological evaluation of potent FAAH inhibitors.

Tuo W, Leleu-Chavain N, Barczyk A, Renault N, Lemaire L, Chavatte P, Millet R.

Bioorg Med Chem Lett. 2016 Jun 1;26(11):2701-5. doi: 10.1016/j.bmcl.2016.04.004. Epub 2016 Apr 23.


Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents.

Driowya M, Leclercq J, Verones V, Barczyk A, Lecoeur M, Renault N, Flouquet N, Ghinet A, Berthelot P, Lebegue N.

Eur J Med Chem. 2016 Jun 10;115:393-405. doi: 10.1016/j.ejmech.2016.03.056. Epub 2016 Mar 22.


Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines.

Moas-Héloire V, Renault N, Batalha V, Arias AR, Marchivie M, Yous S, Deguine N, Buée L, Chavatte P, Blum D, Lopes L, Melnyk P, Agouridas L.

Eur J Med Chem. 2015 Dec 1;106:15-25. doi: 10.1016/j.ejmech.2015.10.030. Epub 2015 Oct 19.


Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.

El Bakali J, Muccioli GG, Body-Malapel M, Djouina M, Klupsch F, Ghinet A, Barczyk A, Renault N, Chavatte P, Desreumaux P, Lambert DM, Millet R.

ACS Med Chem Lett. 2014 Dec 4;6(2):198-203. doi: 10.1021/ml500439x. eCollection 2015 Feb 12.


Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations.

Laurent X, Renault N, Farce A, Chavatte P, Hénon E.

PLoS Comput Biol. 2014 Nov 6;10(11):e1003902. doi: 10.1371/journal.pcbi.1003902. eCollection 2014 Nov.


Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

Laurent X, Bertin B, Renault N, Farce A, Speca S, Milhomme O, Millet R, Desreumaux P, Hénon E, Chavatte P.

J Med Chem. 2014 Jul 10;57(13):5489-508. doi: 10.1021/jm4010863. Epub 2014 Feb 12. Review.


3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

Tourteau A, Andrzejak V, Body-Malapel M, Lemaire L, Lemoine A, Mansouri R, Djouina M, Renault N, El Bakali J, Desreumaux P, Muccioli GG, Lambert DM, Chavatte P, Rigo B, Leleu-Chavain N, Millet R.

Bioorg Med Chem. 2013 Sep 1;21(17):5383-94. doi: 10.1016/j.bmc.2013.06.010. Epub 2013 Jun 15.


Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes.

Karamitri A, Renault N, Clement N, Guillaume JL, Jockers R.

Mol Endocrinol. 2013 Aug;27(8):1217-33. doi: 10.1210/me.2013-1101. Epub 2013 Jun 24. Review.


Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.

Renault N, Laurent X, Farce A, El Bakali J, Mansouri R, Gervois P, Millet R, Desreumaux P, Furman C, Chavatte P.

Chem Biol Drug Des. 2013 Apr;81(4):442-54. doi: 10.1111/cbdd.12095.


Mixed metallic Ba(Co,Fe)X(0.2)O(3-δ) (X = F, Cl) hexagonal perovskites: drastic effect of Fe-incorporation on structural and electronic features.

Iorgulescu M, Roussel P, Tancret N, Renault N, Porcher F, André G, Kabbour H, Mentré O.

Inorg Chem. 2012 Jul 16;51(14):7598-608. doi: 10.1021/ic3004068. Epub 2012 Jun 27.


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