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Items: 19

1.

Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.

Acton B, Small HF, Smith KM, McGonagle A, Stowell AIJ, James DI, Hamilton NM, Hamilton N, Hitchin JR, Hutton CP, Waddell ID, Ogilvie DJ, Jordan AM.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):560-562. doi: 10.1016/j.bmcl.2018.12.066. Epub 2019 Jan 2.

2.

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

Waszkowycz B, Smith KM, McGonagle AE, Jordan AM, Acton B, Fairweather EE, Griffiths LA, Hamilton NM, Hamilton NS, Hitchin JR, Hutton CP, James DI, Jones CD, Jones S, Mould DP, Small HF, Stowell AIJ, Tucker JA, Waddell ID, Ogilvie DJ.

J Med Chem. 2018 Dec 13;61(23):10767-10792. doi: 10.1021/acs.jmedchem.8b01407. Epub 2018 Nov 19.

PMID:
30403352
3.

Discovery of potent inhibitors of the lysophospholipase autotaxin.

Shah P, Cheasty A, Foxton C, Raynham T, Farooq M, Gutierrez IF, Lejeune A, Pritchard M, Turnbull A, Pang L, Owen P, Boyd S, Stowell A, Jordan A, Hamilton NM, Hitchin JR, Stockley M, MacDonald E, Quesada MJ, Trivier E, Skeete J, Ovaa H, Moolenaar WH, Ryder H.

Bioorg Med Chem Lett. 2016 Nov 15;26(22):5403-5410. doi: 10.1016/j.bmcl.2016.10.036. Epub 2016 Oct 14.

PMID:
27780639
4.

Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.

Jordan AM, Begum H, Fairweather E, Fritzl S, Goldberg K, Hopkins GV, Hamilton NM, Lyons AJ, March HN, Newton R, Small HF, Vishwanath S, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ.

Bioorg Med Chem Lett. 2016 Jun 1;26(11):2724-9. doi: 10.1016/j.bmcl.2016.03.100. Epub 2016 Mar 30.

5.

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi.

Ortiz C, Moraca F, Medeiros A, Botta M, Hamilton N, Comini MA.

Molecules. 2016 Mar 17;21(3):368. doi: 10.3390/molecules21030368.

6.

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.

Newton R, Bowler KA, Burns EM, Chapman PJ, Fairweather EE, Fritzl SJR, Goldberg KM, Hamilton NM, Holt SV, Hopkins GV, Jones SD, Jordan AM, Lyons AJ, Nikki March H, McDonald NQ, Maguire LA, Mould DP, Purkiss AG, Small HF, Stowell AIJ, Thomson GJ, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ.

Eur J Med Chem. 2016 Apr 13;112:20-32. doi: 10.1016/j.ejmech.2016.01.039. Epub 2016 Jan 29.

7.

Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.

Raoof A, Depledge P, Hamilton NM, Hamilton NS, Hitchin JR, Hopkins GV, Jordan AM, Maguire LA, McGonagle AE, Mould DP, Rushbrooke M, Small HF, Smith KM, Thomson GJ, Turlais F, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ.

J Med Chem. 2013 Aug 22;56(16):6352-70. doi: 10.1021/jm400568p. Epub 2013 Jul 31.

PMID:
23859074
8.

Isolation of Mycobacterium thermoresistible from a mesh used in an incisional hernia repair.

Hamilton N, Roadley G.

N Z Med J. 2013 Apr 19;126(1373):81-4.

PMID:
23797080
9.

Medical image. The vanishing lung.

Hamilton N, Hills MA.

N Z Med J. 2012 Sep 21;125(1362):92-4. No abstract available.

PMID:
23178610
10.

Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.

Hamilton NM, Dawson M, Fairweather EE, Hamilton NS, Hitchin JR, James DI, Jones SD, Jordan AM, Lyons AJ, Small HF, Thomson GJ, Waddell ID, Ogilvie DJ.

J Med Chem. 2012 May 10;55(9):4431-45. doi: 10.1021/jm300317k. Epub 2012 Apr 27.

PMID:
22506561
11.

Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.

Lusher SJ, Raaijmakers HC, Vu-Pham D, Dechering K, Lam TW, Brown AR, Hamilton NM, Nimz O, Bosch R, McGuire R, Oubrie A, de Vlieg J.

J Biol Chem. 2011 Oct 7;286(40):35079-86. doi: 10.1074/jbc.M111.273029. Epub 2011 Aug 17.

12.

Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.

Brown AR, Bosies M, Cameron H, Clark J, Cowley A, Craighead M, Elmore MA, Firth A, Goodwin R, Goutcher S, Grant E, Grassie M, Grove SJ, Hamilton NM, Hampson H, Hillier A, Ho KK, Kiczun M, Kingsbury C, Kultgen SG, Littlewood PT, Lusher SJ, Macdonald S, McIntosh L, McIntyre T, Mistry A, Morphy JR, Nimz O, Ohlmeyer M, Pick J, Rankovic Z, Sherborne B, Smith A, Speake M, Spinks G, Thomson F, Watson L, Weston M.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):137-40. doi: 10.1016/j.bmcl.2010.11.054. Epub 2010 Nov 16.

PMID:
21129964
13.
14.

Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.

Palin R, Clark JK, Evans L, Feilden H, Fletcher D, Hamilton NM, Houghton AK, Jones PS, McArthur D, Montgomery B, Ratcliffe PD, Smith AR, Sutherland A, Weston MA, Wishart G.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6441-6. doi: 10.1016/j.bmcl.2009.09.028. Epub 2009 Sep 12.

PMID:
19818611
15.

Antiglucocorticoids, neurogenesis and depression.

Fitzsimons CP, van Hooijdonk LW, Morrow JA, Peeters BW, Hamilton N, Craighead M, Vreugdenhil E.

Mini Rev Med Chem. 2009 Feb;9(2):249-64. Review.

PMID:
19200029
16.

The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia.

Belelli D, Muntoni AL, Merrywest SD, Gentet LJ, Casula A, Callachan H, Madau P, Gemmell DK, Hamilton NM, Lambert JJ, Sillar KT, Peters JA.

Neuropharmacology. 2003 Jul;45(1):57-71.

PMID:
12814659
17.

Novel water soluble 2,6-dimethoxyphenyl ester derivatives with intravenous anaesthetic activity.

Bennett DJ, Anderson A, Buchanan K, Byford A, Cooke A, Gemmell DK, Hamilton NM, Maidment MS, McPhail P, Stevenson DF, Sundaram H, Vijn P.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):1971-5. Erratum in: Bioorg Med Chem Lett. 2003 Sep 1;13(17):2939.

PMID:
12781176
18.

Novel alpha-amino-acid phenolic ester derivatives with intravenous anaesthetic activity.

Cooke A, Anderson A, Bennett J, Buchanan K, Gemmell D, Hamilton N, Maidment M, McPhail P, Stevenson D, Sundaram H.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1107-10.

PMID:
12643922
19.

Interaction of steroids with the GABA(A) receptor.

Hamilton NM.

Curr Top Med Chem. 2002 Aug;2(8):887-902. Review.

PMID:
12171578

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