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Items: 17


In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials.

Evans SJ, Clift MJD, Singh N, Wills JW, Hondow N, Wilkinson TS, Burgum MJ, Brown AP, Jenkins GJ, Doak SH.

Part Fibre Toxicol. 2019 Feb 13;16(1):8. doi: 10.1186/s12989-019-0291-7.


Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses.

Mehta P, Al-Kinani AA, Arshad MS, Singh N, van der Merwe SM, Chang MW, Alany RG, Ahmad Z.

J Pharm Sci. 2019 Apr;108(4):1540-1551. doi: 10.1016/j.xphs.2018.11.036. Epub 2018 Dec 1.


Reprint of: A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies.

Shah UK, Mallia JO, Singh N, Chapman KE, Doak SH, Jenkins GJS.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Oct;834:35-41. doi: 10.1016/j.mrgentox.2018.06.020. Epub 2018 Aug 18.


Electrosprayed mesoporous particles for improved aqueous solubility of a poorly water soluble anticancer agent: in vitro and ex vivo evaluation.

Sayed E, Karavasili C, Ruparelia K, Haj-Ahmad R, Charalambopoulou G, Steriotis T, Giasafaki D, Cox P, Singh N, Giassafaki LN, Mpenekou A, Markopoulou CK, Vizirianakis IS, Chang MW, Fatouros DG, Ahmad Z.

J Control Release. 2018 May 28;278:142-155. doi: 10.1016/j.jconrel.2018.03.031. Epub 2018 Mar 30.


A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies.

Shah UK, Mallia JO, Singh N, Chapman KE, Doak SH, Jenkins GJS.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Jan;825:51-58. doi: 10.1016/j.mrgentox.2017.12.005. Epub 2017 Dec 15.


Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways.

Singh N, Nelson BC, Scanlan LD, Coskun E, Jaruga P, Doak SH.

Int J Mol Sci. 2017 Jul 13;18(7). pii: E1515. doi: 10.3390/ijms18071515. Review.


Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity.

Evans SJ, Clift MJ, Singh N, de Oliveira Mallia J, Burgum M, Wills JW, Wilkinson TS, Jenkins GJ, Doak SH.

Mutagenesis. 2017 Jan;32(1):233-241. doi: 10.1093/mutage/gew054. Epub 2016 Nov 4. Review.


Emerging metrology for high-throughput nanomaterial genotoxicology.

Nelson BC, Wright CW, Ibuki Y, Moreno-Villanueva M, Karlsson HL, Hendriks G, Sims CM, Singh N, Doak SH.

Mutagenesis. 2017 Jan;32(1):215-232. doi: 10.1093/mutage/gew037. Epub 2016 Aug 26. Review.


Analysis of the influence of cell heterogeneity on nanoparticle dose response.

Ware MJ, Godin B, Singh N, Majithia R, Shamsudeen S, Serda RE, Meissner KE, Rees P, Summers HD.

ACS Nano. 2014 Jul 22;8(7):6693-700.


The in vitro micronucleus assay and kinetochore staining: methodology and criteria for the accurate assessment of genotoxicity and cytotoxicity.

Manshian BB, Singh N, Doak SH.

Methods Mol Biol. 2013;1044:269-89. doi: 10.1007/978-1-62703-529-3_14.


The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles.

Singh N, Jenkins GJ, Nelson BC, Marquis BJ, Maffeis TG, Brown AP, Williams PM, Wright CJ, Doak SH.

Biomaterials. 2012 Jan;33(1):163-70. doi: 10.1016/j.biomaterials.2011.09.087. Epub 2011 Oct 24.


Dextran coated ultrafine superparamagnetic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyes.

Griffiths SM, Singh N, Jenkins GJ, Williams PM, Orbaek AW, Barron AR, Wright CJ, Doak SH.

Anal Chem. 2011 May 15;83(10):3778-85. doi: 10.1021/ac200103x. Epub 2011 Apr 20.


STEM mode in the SEM: a practical tool for nanotoxicology.

Hondow N, Harrington J, Brydson R, Doak SH, Singh N, Manshian B, Brown A.

Nanotoxicology. 2011 Jun;5(2):215-27. doi: 10.3109/17435390.2010.535622. Epub 2010 Nov 19.


Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION).

Singh N, Jenkins GJ, Asadi R, Doak SH.

Nano Rev. 2010;1. doi: 10.3402/nano.v1i0.5358. Epub 2010 Sep 21.


Conference scene - nanotoxicology: health and environmental impacts.

Singh N.

Nanomedicine (Lond). 2009 Jun;4(4):385-90. doi: 10.2217/nnm.09.20.


NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.

Singh N, Manshian B, Jenkins GJ, Griffiths SM, Williams PM, Maffeis TG, Wright CJ, Doak SH.

Biomaterials. 2009 Aug;30(23-24):3891-914. doi: 10.1016/j.biomaterials.2009.04.009. Epub 2009 May 8. Review.


The PPAR-gamma activator, Rosiglitazone, inhibits actin polymerisation in monocytes: involvement of Akt and intracellular calcium.

Singh N, Webb R, Adams R, Evans SA, Al-Mosawi A, Evans M, Roberts AW, Thomas AW.

Biochem Biophys Res Commun. 2005 Jul 29;333(2):455-62.


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