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Int J Mol Sci. 2019 Jan 8;20(1). pii: E217. doi: 10.3390/ijms20010217.

Evaluation of the Biological Behavior of a Gold Nanocore-Encapsulated Human Serum Albumin Nanoparticle (Au@HSANP) in a CT-26 Tumor/Ascites Mouse Model after Intravenous/Intraperitoneal Administration.

Author information

1
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. jimmy10421@gmail.com.
2
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. uvpxyz@gmail.com.
3
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. dognew0811@gmail.com.
4
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. boxes129@gmail.com.
5
Radiotherapy, Department of Medical Imaging, Cheng Hsin General Hospital, Taipei 112, Taiwan. chungyihwang@yahoo.com.tw.
6
Institute of Nuclear Energy Research, Taoyuan 325, Taiwan. jezon@iner.gov.tw.
7
Institute of Nuclear Energy Research, Taoyuan 325, Taiwan. wjlin@iner.gov.tw.
8
Shin Kong Wu Ho-Su memorial hospital, Taipei 111, Taiwan. M006565@ms.skh.org.tw.
9
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. yjlee2@ym.edu.tw.
10
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. rsliu@vghtpe.gov.tw.
11
Molecular and Genetic Imaging Core/Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei 115, Taiwan. rsliu@vghtpe.gov.tw.
12
Department of Nuclear Medicine and National PET/Cyclotron Center, Taipei Veterans General Hospital, Taipei 112, Taiwan. rsliu@vghtpe.gov.tw.
13
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. clchen2@ym.edu.tw.
14
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. hewang@ym.edu.tw.

Abstract

Colorectal cancer is one of the major causes of cancer-related death in Taiwan and worldwide. Patients with peritoneal metastasis from colorectal cancer have reduced overall survival and poor prognosis. Hybrid protein-inorganic nanoparticle systems have displayed multifunctional applications in solid cancer theranostics. In this study, a gold nanocore-encapsulated human serum albumin nanoparticle (Au@HSANP), which is a hybrid protein-inorganic nanoparticle, and its radioactive surrogate 111In-labeled Au@HSANP (111In-Au@HSANP), were developed and their biological behaviors were investigated in a tumor/ascites mouse model. 111In-Au@HSANP was injected either intravenously (iv) or intraperitoneally (ip) in CT-26 tumor/ascites-bearing mice. After ip injection, a remarkable and sustained radioactivity retention in the abdomen was noticed, based on microSPECT images. After iv injection, however, most of the radioactivity was accumulated in the mononuclear phagocyte system. The results of biodistribution indicated that ip administration was significantly more effective in increasing intraperitoneal concentration and tumor accumulation than iv administration. The ratios of area under the curve (AUC) of the ascites and tumors in the ip-injected group to those in the iv-injected group was 93 and 20, respectively. This study demonstrated that the ip injection route would be a better approach than iv injections for applying gold-albumin nanoparticle in peritoneal metastasis treatment.

KEYWORDS:

Hybrid protein-inorganic nanoparticle; intraperitoneal injection; intravenous injection; tumor/ascites animal model

PMID:
30626093
PMCID:
PMC6337091
DOI:
10.3390/ijms20010217
[Indexed for MEDLINE]
Free PMC Article

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