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Items: 1 to 20 of 23

1.

Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90.

Montoir D, Barillé-Nion S, Tonnerre A, Juin P, Duflos M, Bazin MA.

Eur J Med Chem. 2016 Aug 25;119:17-33. doi: 10.1016/j.ejmech.2016.04.050. Epub 2016 Apr 22.

PMID:
27153346
2.

The Marine-Derived Fungus Clonostachys rosea, Source of a Rare Conjugated 4-Me-6E,8E-hexadecadienoic Acid Reducing Viability of MCF-7 Breast Cancer Cells and Gene Expression of Lipogenic Enzymes.

Dias AC, Ruiz N, Couzinet-Mossion A, Bertrand S, Duflos M, Pouchus YF, Barnathan G, Nazih H, Wielgosz-Collin G.

Mar Drugs. 2015 Aug 6;13(8):4934-48. doi: 10.3390/md13084934.

3.

Discovery of a novel broad-spectrum antifungal agent derived from albaconazole.

Guillon R, Pagniez F, Picot C, Hédou D, Tonnerre A, Chosson E, Duflos M, Besson T, Logé C, Le Pape P.

ACS Med Chem Lett. 2013 Jan 17;4(2):288-92. doi: 10.1021/ml300429p. eCollection 2013 Feb 14.

4.

Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.

Loidreau Y, Marchand P, Dubouilh-Benard C, Nourrisson MR, Duflos M, Loaëc N, Meijer L, Besson T.

Eur J Med Chem. 2013 Jan;59:283-95. doi: 10.1016/j.ejmech.2012.11.030. Epub 2012 Nov 24.

PMID:
23237976
5.

Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors.

Loidreau Y, Marchand P, Dubouilh-Benard C, Nourrisson MR, Duflos M, Lozach O, Loaëc N, Meijer L, Besson T.

Eur J Med Chem. 2012 Dec;58:171-83. doi: 10.1016/j.ejmech.2012.10.006. Epub 2012 Oct 16.

PMID:
23124214
6.

Design, synthesis, and biological evaluation of 1-[(biarylmethyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as potent antifungal agents: new insights into structure-activity relationships.

Guillon R, Pagniez F, Rambaud C, Picot C, Duflos M, Logé C, Le Pape P.

ChemMedChem. 2011 Oct 4;6(10):1806-15. doi: 10.1002/cmdc.201100262. Epub 2011 Jul 11.

PMID:
21748853
7.

Design, synthesis, and in vitro antifungal activity of 1-[(4-substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

Guillon R, Pagniez F, Giraud F, Crépin D, Picot C, Le Borgne M, Morio F, Duflos M, Logé C, Le Pape P.

ChemMedChem. 2011 May 2;6(5):816-25. doi: 10.1002/cmdc.201000530. Epub 2011 Mar 2.

PMID:
21370476
8.

Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1-[(1H-indol-3-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

Guillon R, Logé C, Pagniez F, Ferchaud-Roucher V, Duflos M, Picot C, Le Pape P.

J Enzyme Inhib Med Chem. 2011 Apr;26(2):261-9. doi: 10.3109/14756366.2010.503607. Epub 2010 Aug 9.

PMID:
20695753
9.

Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.

Giraud F, Marchand P, Carbonnelle D, Sartor M, Lang F, Duflos M.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5203-6. doi: 10.1016/j.bmcl.2010.07.001. Epub 2010 Jul 6.

PMID:
20655209
10.

A novel indole-3-propanamide exerts its immunosuppressive activity by inhibiting JAK3 in T cells.

Carbonnelle D, Duflos M, Marchand P, Chauvet C, Petit JY, Lang F.

J Pharmacol Exp Ther. 2009 Nov;331(2):710-6. doi: 10.1124/jpet.109.155986. Epub 2009 Aug 26.

PMID:
19710367
11.

N-Pyridinyl(methyl)-indole-1- or 3-propanamides and propenamides acting as topical and systemic inflammation inhibitors.

Dassonville A, Lardic M, Breteche A, Nourrisson MR, Le Baut G, Grimaud N, Petit JY, Duflos M.

J Enzyme Inhib Med Chem. 2008 Oct;23(5):728-38. doi: 10.1080/14756360802208251 .

PMID:
18821260
12.

Indole carboxamides inhibit bovine testes hyaluronidase at pH 7.0 and indole acetamides activate the enzyme at pH 3.5 by different mechanisms.

Kaessler A, Nourrisson MR, Duflos M, Jose J.

J Enzyme Inhib Med Chem. 2008 Oct;23(5):719-27. doi: 10.1080/14756360802208152 .

PMID:
18821259
13.

Design, synthesis and evaluation of new 6-substituted-5-benzyloxy-4-oxo-4H-pyran-2-carboxamides as potential Src inhibitors.

Farard J, Lanceart G, Logé C, Nourrisson MR, Cruzalegui F, Pfeiffer B, Duflos M.

J Enzyme Inhib Med Chem. 2008 Oct;23(5):629-40. doi: 10.1080/14756360802205299 . Erratum in: J Enzyme Inhib Med Chem. 2008 Dec;23(6):1028.

PMID:
18686137
14.

Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety.

Lebouvier N, Pagniez F, Duflos M, Le Pape P, Na YM, Le Baut G, Le Borgne M.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3686-9. Epub 2007 Apr 19.

PMID:
17482460
15.

Synthetic N-pyridinyl(methyl)-indol-3-ylpropanamides as new potential immunosuppressive agents.

Carbonnelle D, Lardic M, Dassonville A, Verron E, Petit JY, Duflos M, Lang F.

Eur J Med Chem. 2007 May;42(5):686-93. Epub 2007 Jan 9.

PMID:
17316917
16.

Synthesis and primary cytotoxicity evaluation of arylmethylenenaphthofuranones derivatives.

Lardic M, Patry C, Duflos M, Guillon J, Massip S, Cruzalegui F, Edmonds T, Giraudet S, Marini L, Leonce S.

J Enzyme Inhib Med Chem. 2006 Jun;21(3):313-25.

PMID:
16918079
17.

Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors.

Lézé MP, Le Borgne M, Pinson P, Palusczak A, Duflos M, Le Baut G, Hartmann RW.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1134-7. Epub 2005 Dec 27.

PMID:
16380254
18.

New N-pyridinyl(methyl)-indolalkanamides acting as topical inflammation inhibitors.

Dassonville A, Bretéché A, Evano J, Duflos M, le Baut G, Grimaud N, Petit JY.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5441-4.

PMID:
15454241
19.

Potential inhibitors of angiogenesis. Part II: 3-(azolylmethylene)-2,3-dihydrobenzo[b]furan-2-ones.

Braud E, Duflos M, Le Baut G, Renard P, Pfeiffer B, Tucker G.

J Enzyme Inhib Med Chem. 2003 Jun;18(3):253-7.

PMID:
14506916
20.

Potential inhibitors of angiogenesis. Part I: 3-(imidazol-4(5)-ylmethylene)indolin-2-ones.

Braud E, Duflos M, Nourrisson MR, Tonnerre A, Picot C, Le Baut G, Renard P, Pfeiffer B, Tucker G.

J Enzyme Inhib Med Chem. 2003 Jun;18(3):243-52.

PMID:
14506915

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