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Items: 1 to 20 of 135


How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers.

Bhat S, Newman AH, Freissmuth M.

Biochem Soc Trans. 2019 May 7. pii: BST20180512. doi: 10.1042/BST20180512. [Epub ahead of print] Review.


para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter.

Niello M, Cintulova D, Hellsberg E, Jäntsch K, Holy M, Ayatollahi LH, Cozzi NV, Freissmuth M, Sandtner W, Ecker GF, Mihovilovic MD, Sitte HH.

Neuropharmacology. 2019 Apr 24. pii: S0028-3908(19)30137-6. doi: 10.1016/j.neuropharm.2019.04.021. [Epub ahead of print]


Nature-Derived Peptides: A Growing Niche for GPCR Ligand Discovery.

Muratspahić E, Freissmuth M, Gruber CW.

Trends Pharmacol Sci. 2019 May;40(5):309-326. doi: 10.1016/ Epub 2019 Apr 5. Review.


Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome.

El-Kasaby A, Kasture A, Koban F, Hotka M, Asjad HMM, Kubista H, Freissmuth M, Sucic S.

Neuropharmacology. 2019 Mar 15. pii: S0028-3908(19)30100-5. doi: 10.1016/j.neuropharm.2019.03.015. [Epub ahead of print]


Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction.

Kasture AS, Bartel D, Steinkellner T, Sucic S, Hummel T, Freissmuth M.

Neuropharmacology. 2019 Mar 6. pii: S0028-3908(19)30084-X. doi: 10.1016/j.neuropharm.2019.03.007. [Epub ahead of print]


Functional Selectivity and Partial Efficacy at the Monoamine Transporters: A Unified Model of Allosteric Modulation and Amphetamine-Induced Substrate Release.

Hasenhuetl PS, Bhat S, Freissmuth M, Sandtner W.

Mol Pharmacol. 2019 Mar;95(3):303-312. doi: 10.1124/mol.118.114793. Epub 2018 Dec 19.


Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome.

Themanns M, Koban F, Bergmayr C, Chrzan A, Strohmaier W, Haybaeck J, Freissmuth M, Zebedin-Brandl E.

J Mol Med (Berl). 2019 Feb;97(2):201-213. doi: 10.1007/s00109-018-1726-6. Epub 2018 Dec 7.


Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum.

Kovalchuk V, Samluk Ł, Juraszek B, Jurkiewicz-Trząska D, Sucic S, Freissmuth M, Nałęcz KA.

Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):252-263. doi: 10.1016/j.bbamcr.2018.11.005. Epub 2018 Nov 14.


Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems.

Kasture AS, Hummel T, Sucic S, Freissmuth M.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1788. doi: 10.3390/ijms19061788. Review.


Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter.

Hamali B, Pichler S, Wischnitzki E, Schicker K, Burger M, Holy M, Jaentsch K, Molin M, Sehr EM, Kudlacek O, Freissmuth M.

PLoS Negl Trop Dis. 2018 Apr 27;12(4):e0006428. doi: 10.1371/journal.pntd.0006428. eCollection 2018 Apr.


A label-free approach to detect ligand binding to cell surface proteins in real time.

Burtscher V, Hotka M, Li Y, Freissmuth M, Sandtner W.

Elife. 2018 Apr 26;7. pii: e34944. doi: 10.7554/eLife.34944.


A kinetic account for amphetamine-induced monoamine release.

Hasenhuetl PS, Bhat S, Mayer FP, Sitte HH, Freissmuth M, Sandtner W.

J Gen Physiol. 2018 Feb 9. pii: jgp.201711915. doi: 10.1085/jgp.201711915. [Epub ahead of print]


Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation.

Nizet S, Muñoz E, Fiebich BL, Abuja PM, Kashofer K, Zatloukal K, Tangermann S, Kenner L, Tschegg C, Nagl D, Scheichl L, Meisslitzer-Ruppitsch C, Freissmuth M, Berger T.

Inflamm Bowel Dis. 2017 Dec 19;24(1):54-66. doi: 10.1093/ibd/izx042. Erratum in: Inflamm Bowel Dis. 2018 Oct 12;24(11):2478.


Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.

Asjad HMM, Nasrollahi-Shirazi S, Sucic S, Freissmuth M, Nanoff C.

Int J Mol Sci. 2017 Nov 14;18(11). pii: E2416. doi: 10.3390/ijms18112416. Review.


SLC6 Transporter Folding Diseases and Pharmacochaperoning.

Freissmuth M, Stockner T, Sucic S.

Handb Exp Pharmacol. 2018;245:249-270. doi: 10.1007/164_2017_71. Review.


Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism.

Asjad HMM, Kasture A, El-Kasaby A, Sackel M, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2017 Nov 24;292(47):19250-19265. doi: 10.1074/jbc.M117.797092. Epub 2017 Sep 29.


An unfolding story: Small molecules remedy misfolded monoamine transporters.

Kasture A, Stockner T, Freissmuth M, Sucic S.

Int J Biochem Cell Biol. 2017 Nov;92:1-5. doi: 10.1016/j.biocel.2017.09.004. Epub 2017 Sep 7. Review.


Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M.

J Biol Chem. 2017 Oct 6;292(40):16773-16786. doi: 10.1074/jbc.M117.794081. Epub 2017 Aug 23.


Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition.

Yang Q, Puhm F, Freissmuth M, Nanoff C.

Cancer Chemother Pharmacol. 2017 Oct;80(4):673-684. doi: 10.1007/s00280-017-3390-x. Epub 2017 Aug 4.


Cocaine adulteration.

Kudlacek O, Hofmaier T, Luf A, Mayer FP, Stockner T, Nagy C, Holy M, Freissmuth M, Schmid R, Sitte HH.

J Chem Neuroanat. 2017 Oct;83-84:75-81. doi: 10.1016/j.jchemneu.2017.06.001. Epub 2017 Jun 12. Review.


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