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Items: 1 to 20 of 54


Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH.

Singh V, Pacitto A, Donini S, Ferraris DM, Boros S, Illyés E, Szokol B, Rizzi M, Blundell TL, Ascher DB, Pato J, Mizrahi V.

Eur J Med Chem. 2019 Jul 15;174:309-329. doi: 10.1016/j.ejmech.2019.04.027. Epub 2019 Apr 15.


The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue.

Rossi F, Miggiano R, Ferraris DM, Rizzi M.

Front Mol Biosci. 2019 Feb 27;6:7. doi: 10.3389/fmolb.2019.00007. eCollection 2019. Review.


Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.

Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L.

J Med Chem. 2018 Jun 14;61(11):4739-4756. doi: 10.1021/acs.jmedchem.7b01839. Epub 2018 May 30.


Hit discovery of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase, GuaB2, inhibitors.

Sahu NU, Singh V, Ferraris DM, Rizzi M, Kharkar PS.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1714-1718. doi: 10.1016/j.bmcl.2018.04.045. Epub 2018 Apr 18.


Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

Mori M, Deodato D, Kasula M, Ferraris DM, Sanna A, De Logu A, Rizzi M, Botta M.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):637-641. doi: 10.1016/j.bmcl.2018.01.031. Epub 2018 Jan 31.


Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets.

Ferraris DM, Miggiano R, Rossi F, Rizzi M.

Pathogens. 2018 Feb 1;7(1). pii: E17. doi: 10.3390/pathogens7010017. Review.


Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights.

Miggiano R, Valenti A, Rossi F, Rizzi M, Perugino G, Ciaramella M.

Int J Mol Sci. 2017 Dec 5;18(12). pii: E2613. doi: 10.3390/ijms18122613. Review.


Mycobacterium tuberculosis UvrB forms dimers in solution and interacts with UvrA in the absence of ligands.

Lahiri S, Rizzi M, Rossi F, Miggiano R.

Proteins. 2018 Jan;86(1):98-109. doi: 10.1002/prot.25412. Epub 2017 Nov 11.


Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.

Donini S, Ferraris DM, Miggiano R, Massarotti A, Rizzi M.

Sci Rep. 2017 Apr 26;7(1):1180. doi: 10.1038/s41598-017-01057-z.


Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis.

Donini S, Garavaglia S, Ferraris DM, Miggiano R, Mori S, Shibayama K, Rizzi M.

PLoS One. 2017 Apr 18;12(4):e0175815. doi: 10.1371/journal.pone.0175815. eCollection 2017.


Interdomain interactions rearrangements control the reaction steps of a thermostable DNA alkyltransferase.

Morrone C, Miggiano R, Serpe M, Massarotti A, Valenti A, Del Monaco G, Rossi M, Rossi F, Rizzi M, Perugino G, Ciaramella M.

Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):86-96. doi: 10.1016/j.bbagen.2016.10.020. Epub 2016 Oct 22.


Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD+ and retinoic acid.

Moretti A, Li J, Donini S, Sobol RW, Rizzi M, Garavaglia S.

Sci Rep. 2016 Oct 19;6:35710. doi: 10.1038/srep35710.


The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.

Singh V, Donini S, Pacitto A, Sala C, Hartkoorn RC, Dhar N, Keri G, Ascher DB, Mondésert G, Vocat A, Lupien A, Sommer R, Vermet H, Lagrange S, Buechler J, Warner DF, McKinney JD, Pato J, Cole ST, Blundell TL, Rizzi M, Mizrahi V.

ACS Infect Dis. 2017 Jan 13;3(1):5-17. doi: 10.1021/acsinfecdis.6b00102. Epub 2016 Sep 8.


Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

Park Y, Pacitto A, Bayliss T, Cleghorn LA, Wang Z, Hartman T, Arora K, Ioerger TR, Sacchettini J, Rizzi M, Donini S, Blundell TL, Ascher DB, Rhee K, Breda A, Zhou N, Dartois V, Jonnala SR, Via LE, Mizrahi V, Epemolu O, Stojanovski L, Simeons F, Osuna-Cabello M, Ellis L, MacKenzie CJ, Smith AR, Davis SH, Murugesan D, Buchanan KI, Turner PA, Huggett M, Zuccotto F, Rebollo-Lopez MJ, Lafuente-Monasterio MJ, Sanz O, Diaz GS, Lelièvre J, Ballell L, Selenski C, Axtman M, Ghidelli-Disse S, Pflaumer H, Bösche M, Drewes G, Freiberg GM, Kurnick MD, Srikumaran M, Kempf DJ, Green SR, Ray PC, Read K, Wyatt P, Barry CE 3rd, Boshoff HI.

ACS Infect Dis. 2017 Jan 13;3(1):18-33. doi: 10.1021/acsinfecdis.6b00103. Epub 2016 Oct 17.


Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.

Miggiano R, Perugino G, Ciaramella M, Serpe M, Rejman D, Páv O, Pohl R, Garavaglia S, Lahiri S, Rizzi M, Rossi F.

Biochem J. 2016 Jan 15;473(2):123-33. doi: 10.1042/BJ20150833. Epub 2015 Oct 28.


Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.

Perugino G, Miggiano R, Serpe M, Vettone A, Valenti A, Lahiri S, Rossi F, Rossi M, Rizzi M, Ciaramella M.

Nucleic Acids Res. 2015 Oct 15;43(18):8801-16. doi: 10.1093/nar/gkv774. Epub 2015 Jul 30.


Crystal structure of human nicotinic acid phosphoribosyltransferase.

Marletta AS, Massarotti A, Orsomando G, Magni G, Rizzi M, Garavaglia S.

FEBS Open Bio. 2015 May 7;5:419-28. doi: 10.1016/j.fob.2015.05.002. eCollection 2015.


Structures of citrate synthase and malate dehydrogenase of Mycobacterium tuberculosis.

Ferraris DM, Spallek R, Oehlmann W, Singh M, Rizzi M.

Proteins. 2015 Feb;83(2):389-94. doi: 10.1002/prot.24743. Epub 2015 Jan 7.


Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.

Audrito V, Serra S, Brusa D, Mazzola F, Arruga F, Vaisitti T, Coscia M, Maffei R, Rossi D, Wang T, Inghirami G, Rizzi M, Gaidano G, Garcia JG, Wolberger C, Raffaelli N, Deaglio S.

Blood. 2015 Jan 1;125(1):111-23. doi: 10.1182/blood-2014-07-589069. Epub 2014 Nov 3.


Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.

Mori M, Moraca F, Deodato D, Ferraris DM, Selchow P, Sander P, Rizzi M, Botta M.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2508-11. doi: 10.1016/j.bmcl.2014.04.004. Epub 2014 Apr 13.


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