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Items: 1 to 20 of 264

1.

Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein.

Mori M, Dasso Lang MC, Saladini F, Palombi N, Kovalenko L, De Forni D, Poddesu B, Friggeri L, Giannini A, Malancona S, Summa V, Zazzi M, Mely Y, Botta M.

ACS Med Chem Lett. 2018 Dec 7;10(4):463-468. doi: 10.1021/acsmedchemlett.8b00506. eCollection 2019 Apr 11.

PMID:
30996780
2.

Highlighting Medicinal Chemistry in Italy Special Issue.

Botta M.

ACS Med Chem Lett. 2019 Apr 11;10(4):395. doi: 10.1021/acsmedchemlett.9b00137. eCollection 2019 Apr 11. No abstract available.

PMID:
30996768
3.

Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02.

Iralde-Lorente L, Cau Y, Clementi L, Franci L, Tassone G, Valensin D, Mori M, Angelucci A, Chiariello M, Botta M.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):657-664. doi: 10.1080/14756366.2019.1574779.

PMID:
30727786
4.

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.

Brai A, Martelli F, Riva V, Garbelli A, Fazi R, Zamperini C, Pollutri A, Falsitta L, Ronzini S, Maccari L, Maga G, Giannecchini S, Botta M.

J Med Chem. 2019 Mar 14;62(5):2333-2347. doi: 10.1021/acs.jmedchem.8b01403. Epub 2019 Feb 21.

PMID:
30721061
5.

Novel broad spectrum virucidal molecules against enveloped viruses.

Cagno V, Tintori C, Civra A, Cavalli R, Tiberi M, Botta L, Brai A, Poli G, Tapparel C, Lembo D, Botta M.

PLoS One. 2018 Dec 7;13(12):e0208333. doi: 10.1371/journal.pone.0208333. eCollection 2018.

6.

One-pot synthesis of spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitriles as p53-MDM2 interaction inhibitors.

Ibrahim HS, Eldehna WM, Fallacara AL, Ahmed ER, Ghabbour HA, Elaasser MM, Botta M, Abou-Seri SM, Abdel-Aziz HA.

Future Med Chem. 2018 Dec;10(24):2771-2789. doi: 10.4155/fmc-2018-0288. Epub 2018 Dec 10.

PMID:
30526032
7.

Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization.

Pasero C, D'Agostino I, De Luca F, Zamperini C, Deodato D, Truglio GI, Sannio F, Del Prete R, Ferraro T, Visaggio D, Mancini A, Guglielmi MB, Visca P, Docquier JD, Botta M.

J Med Chem. 2018 Oct 25;61(20):9162-9176. doi: 10.1021/acs.jmedchem.8b00619. Epub 2018 Oct 11.

PMID:
30265809
8.

Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.

Molinari A, Fallacara AL, Di Maria S, Zamperini C, Poggialini F, Musumeci F, Schenone S, Angelucci A, Colapietro A, Crespan E, Kissova M, Maga G, Botta M.

Bioorg Med Chem Lett. 2018 Nov 15;28(21):3454-3457. doi: 10.1016/j.bmcl.2018.09.024. Epub 2018 Sep 20.

PMID:
30262428
9.

Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.

Tassone G, Mangani S, Botta M, Pozzi C.

Biochim Biophys Acta Proteins Proteom. 2018 Nov;1866(11):1190-1198. doi: 10.1016/j.bbapap.2018.09.005. Epub 2018 Sep 21.

PMID:
30248409
10.

Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction.

D'Agostino I, Giacchello I, Nannetti G, Fallacara AL, Deodato D, Musumeci F, Grossi G, Palù G, Cau Y, Trist IM, Loregian A, Schenone S, Botta M.

Eur J Med Chem. 2018 Sep 5;157:743-758. doi: 10.1016/j.ejmech.2018.08.032. Epub 2018 Aug 13.

PMID:
30142611
11.

Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-d]pyrimidines for Targeting Hepatocellular Carcinoma.

Calandro P, Iovenitti G, Zamperini C, Candita F, Dreassi E, Chiariello M, Angelucci A, Schenone S, Botta M, Mancini A.

ACS Med Chem Lett. 2018 May 7;9(7):646-651. doi: 10.1021/acsmedchemlett.8b00062. eCollection 2018 Jul 12.

PMID:
30034594
12.

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.

Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI.

J Med Chem. 2018 Jul 12;61(13):5679-5691. doi: 10.1021/acs.jmedchem.8b00641. Epub 2018 Jun 25.

PMID:
29894182
13.

Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides.

Tintori C, Iovenitti G, Ceresola ER, Ferrarese R, Zamperini C, Brai A, Poli G, Dreassi E, Cagno V, Lembo D, Canducci F, Botta M.

PLoS One. 2018 Jun 5;13(6):e0198478. doi: 10.1371/journal.pone.0198478. eCollection 2018.

14.

Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

Mori M, Deodato D, Kasula M, Ferraris DM, Sanna A, De Logu A, Rizzi M, Botta M.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):637-641. doi: 10.1016/j.bmcl.2018.01.031. Epub 2018 Jan 31.

PMID:
29395975
15.

Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein.

Gamba E, Mori M, Kovalenko L, Giannini A, Sosic A, Saladini F, Fabris D, Mély Y, Gatto B, Botta M.

Eur J Med Chem. 2018 Feb 10;145:154-164. doi: 10.1016/j.ejmech.2017.12.073. Epub 2017 Dec 24.

PMID:
29324338
16.

Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.

Mascarello A, Orbem Menegatti AC, Calcaterra A, Martins PGA, Chiaradia-Delatorre LD, D'Acquarica I, Ferrari F, Pau V, Sanna A, De Logu A, Botta M, Botta B, Terenzi H, Mori M.

Eur J Med Chem. 2018 Jan 20;144:277-288. doi: 10.1016/j.ejmech.2017.11.087. Epub 2017 Dec 7.

PMID:
29275228
17.

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.

Cau Y, Vullo D, Mori M, Dreassi E, Supuran CT, Botta M.

Molecules. 2017 Dec 22;23(1). pii: E17. doi: 10.3390/molecules23010017.

18.

Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains.

Mori M, Kovalenko L, Malancona S, Saladini F, De Forni D, Pires M, Humbert N, Real E, Botzanowski T, Cianférani S, Giannini A, Dasso Lang MC, Cugia G, Poddesu B, Lori F, Zazzi M, Harper S, Summa V, Mely Y, Botta M.

ACS Chem Biol. 2018 Jan 19;13(1):253-266. doi: 10.1021/acschembio.7b00907. Epub 2017 Dec 28.

PMID:
29235845
19.

Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.

Poli G, Di Fabio R, Ferrante L, Summa V, Botta M.

ChemMedChem. 2017 Dec 7;12(23):1917-1926. doi: 10.1002/cmdc.201700563. Epub 2017 Nov 17. Review.

PMID:
29117473
20.

Modulators of 14-3-3 Protein-Protein Interactions.

Stevers LM, Sijbesma E, Botta M, MacKintosh C, Obsil T, Landrieu I, Cau Y, Wilson AJ, Karawajczyk A, Eickhoff J, Davis J, Hann M, O'Mahony G, Doveston RG, Brunsveld L, Ottmann C.

J Med Chem. 2018 May 10;61(9):3755-3778. doi: 10.1021/acs.jmedchem.7b00574. Epub 2017 Oct 19.

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