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Items: 1 to 20 of 196

1.

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.

Mavroeidi P, Arvanitaki F, Karakitsou AK, Vetsi M, Kloukina I, Zweckstetter M, Giller K, Becker S, Sorrentino ZA, Giasson BI, Jensen PH, Stefanis L, Xilouri M.

Acta Neuropathol. 2019 Apr 22. doi: 10.1007/s00401-019-02014-y. [Epub ahead of print]

PMID:
31011860
2.

Structure and Functions of Microtubule Associated Proteins Tau and MAP2c: Similarities and Differences.

Melková K, Zapletal V, Narasimhan S, Jansen S, Hritz J, Škrabana R, Zweckstetter M, Ringkjøbing Jensen M, Blackledge M, Žídek L.

Biomolecules. 2019 Mar 16;9(3). pii: E105. doi: 10.3390/biom9030105. Review.

3.

In response to: The validity of 18F-GE180 as a TSPO imaging agent.

Albert NL, Unterrainer M, Brendel M, Kaiser L, Zweckstetter M, Cumming P, Bartenstein P.

Eur J Nucl Med Mol Imaging. 2019 Jun;46(6):1208-1211. doi: 10.1007/s00259-019-04294-8. Epub 2019 Mar 2. No abstract available.

PMID:
30826897
4.

Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism.

Gong J, Szego ÉM, Leonov A, Benito E, Becker S, Fischer A, Zweckstetter M, Outeiro T, Schneider A.

J Neurosci. 2019 May 8;39(19):3752-3769. doi: 10.1523/JNEUROSCI.2070-18.2019. Epub 2019 Feb 22.

PMID:
30796158
5.

Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-protein in children with neurodevelopmental disorders.

Rankovic M, Zweckstetter M.

Neurosci Biobehav Rev. 2019 Mar;98:1-9. doi: 10.1016/j.neubiorev.2018.12.014. Epub 2018 Dec 11. Review.

PMID:
30550860
6.

Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa.

Pellkofer H, Ihler F, Weiss BG, Trothe J, Kadavath H, Chongtham M, Kunadt M, Riedel D, Lornsen F, Wilken P, Bartels C, Hirschel S, Russo SG, Stransky E, Trojan L, Schmidt B, Mandelkow E, Zweckstetter M, Canis M, Schneider A.

Eur Arch Psychiatry Clin Neurosci. 2018 Nov 12. doi: 10.1007/s00406-018-0955-6. [Epub ahead of print]

PMID:
30421149
7.

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.

Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M.

Nat Commun. 2018 Oct 31;9(1):4532. doi: 10.1038/s41467-018-06880-0.

8.

Insights into Cholesterol/Membrane Protein Interactions Using Paramagnetic Solid-State NMR.

Jaipuria G, Giller K, Leonov A, Becker S, Zweckstetter M.

Chemistry. 2018 Nov 27;24(66):17606-17611. doi: 10.1002/chem.201804550. Epub 2018 Nov 5.

PMID:
30255522
9.

Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features.

Gentile I, Garro HA, Delgado Ocaña S, Gonzalez N, Strohäker T, Schibich D, Quintanar L, Sambrotta L, Zweckstetter M, Griesinger C, Menacho Márquez M, Fernández CO.

Metallomics. 2018 Oct 17;10(10):1383-1389. doi: 10.1039/c8mt00232k.

PMID:
30246210
10.

Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.

Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Piqué A, Szego É, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.

Hum Mol Genet. 2019 Jan 1;28(1):31-50. doi: 10.1093/hmg/ddy326.

PMID:
30219847
11.

Local and Global Dynamics in Intrinsically Disordered Synuclein.

Rezaei-Ghaleh N, Parigi G, Soranno A, Holla A, Becker S, Schuler B, Luchinat C, Zweckstetter M.

Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15262-15266. doi: 10.1002/anie.201808172. Epub 2018 Oct 18.

PMID:
30184304
12.

RNA polymerase II clustering through carboxy-terminal domain phase separation.

Boehning M, Dugast-Darzacq C, Rankovic M, Hansen AS, Yu T, Marie-Nelly H, McSwiggen DT, Kokic G, Dailey GM, Cramer P, Darzacq X, Zweckstetter M.

Nat Struct Mol Biol. 2018 Sep;25(9):833-840. doi: 10.1038/s41594-018-0112-y. Epub 2018 Aug 20.

PMID:
30127355
13.

Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics.

Melková K, Zapletal V, Jansen S, Nomilner E, Zachrdla M, Hritz J, Nováček J, Zweckstetter M, Jensen MR, Blackledge M, Žídek L.

J Biol Chem. 2018 Aug 24;293(34):13297-13309. doi: 10.1074/jbc.RA118.001769. Epub 2018 Jun 20.

PMID:
29925592
14.

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.

Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE.

Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30.

15.

The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease.

Aliakbari F, Mohammad-Beigi H, Rezaei-Ghaleh N, Becker S, Dehghani Esmatabad F, Eslampanah Seyedi HA, Bardania H, Tayaranian Marvian A, Collingwood JF, Christiansen G, Zweckstetter M, Otzen DE, Morshedi D.

Nanoscale. 2018 May 17;10(19):9174-9185. doi: 10.1039/c8nr00632f.

PMID:
29725687
16.

Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity.

Tolö J, Taschenberger G, Leite K, Stahlberg MA, Spehlbrink G, Kues J, Munari F, Capaldi S, Becker S, Zweckstetter M, Dean C, Bähr M, Kügler S.

Front Mol Neurosci. 2018 Mar 7;11:49. doi: 10.3389/fnmol.2018.00049. eCollection 2018.

17.

Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view.

Jaipuria G, Ukmar-Godec T, Zweckstetter M.

Cell Mol Life Sci. 2018 Jun;75(12):2137-2151. doi: 10.1007/s00018-018-2789-9. Epub 2018 Mar 8. Review.

PMID:
29520423
18.

The Binding Mode of a Tau Peptide with Tubulin.

Kadavath H, Cabrales Fontela Y, Jaremko M, Jaremko Ł, Overkamp K, Biernat J, Mandelkow E, Zweckstetter M.

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3246-3250. doi: 10.1002/anie.201712089. Epub 2018 Feb 22.

PMID:
29314492
19.

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.

Cabrales Fontela Y, Kadavath H, Biernat J, Riedel D, Mandelkow E, Zweckstetter M.

Nat Commun. 2017 Dec 7;8(1):1981. doi: 10.1038/s41467-017-02230-8.

20.

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.

Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A.

EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825.

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