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Items: 12

1.

Pharmacokinetics and disposition of miltefosine in healthy mice and hamsters experimentally infected with Leishmania infantum.

Jiménez-Antón MD, García-Calvo E, Gutiérrez C, Escribano MD, Kayali N, Luque-García JL, Olías-Molero AI, Corral MJ, Costi MP, Torrado JJ, Alunda JM.

Eur J Pharm Sci. 2018 Aug 30;121:281-286. doi: 10.1016/j.ejps.2018.06.002. Epub 2018 Jun 5.

PMID:
29883726
2.

Proteomic and Bioinformatic Studies for the Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian Cancer.

Severi L, Losi L, Fonda S, Taddia L, Gozzi G, Marverti G, Magni F, Chinello C, Stella M, Sheouli J, Braicu EI, Genovese F, Lauriola A, Marraccini C, Gualandi A, D'Arca D, Ferrari S, Costi MP.

Front Pharmacol. 2018 May 8;9:454. doi: 10.3389/fphar.2018.00454. eCollection 2018.

3.

In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I.

Herrmann FC, Sivakumar N, Jose J, Costi MP, Pozzi C, Schmidt TJ.

Molecules. 2017 Dec 6;22(12). pii: E2166. doi: 10.3390/molecules22122166.

4.

Label-free fiber optic optrode for the detection of class C β-lactamases expressed by drug resistant bacteria.

Zuppolini S, Quero G, Consales M, Diodato L, Vaiano P, Venturelli A, Santucci M, Spyrakis F, Costi MP, Giordano M, Cutolo A, Cusano A, Borriello A.

Biomed Opt Express. 2017 Oct 23;8(11):5191-5205. doi: 10.1364/BOE.8.005191. eCollection 2017 Nov 1.

5.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

Linciano P, Dawson A, Pöhner I, Costa DM, Sá MS, Cordeiro-da-Silva A, Luciani R, Gul S, Witt G, Ellinger B, Kuzikov M, Gribbon P, Reinshagen J, Wolf M, Behrens B, Hannaert V, Michels PAM, Nerini E, Pozzi C, di Pisa F, Landi G, Santarem N, Ferrari S, Saxena P, Lazzari S, Cannazza G, Freitas-Junior LH, Moraes CB, Pascoalino BS, Alcântara LM, Bertolacini CP, Fontana V, Wittig U, Müller W, Wade RC, Hunter WN, Mangani S, Costantino L, Costi MP.

ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11.

6.

Decoding the Structural Basis For Carbapenem Hydrolysis By Class A β-lactamases: Fishing For A Pharmacophore.

Tondi D, Cross S, Venturelli A, Costi MP, Cruciani G, Spyrakis F.

Curr Drug Targets. 2016;17(9):983-1005. Review.

PMID:
26424401
7.

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.

Eadsforth TC, Pinto A, Luciani R, Tamborini L, Cullia G, De Micheli C, Marinelli L, Cosconati S, Novellino E, Lo Presti L, Cordeiro da Silva A, Conti P, Hunter WN, Costi MP.

J Med Chem. 2015 Oct 22;58(20):7938-48. doi: 10.1021/acs.jmedchem.5b00687. Epub 2015 Sep 16.

8.

Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.

Tochowicz A, Santucci M, Saxena P, Guaitoli G, Trande M, Finer-Moore J, Stroud RM, Costi MP.

J Med Chem. 2015 Jan 22;58(2):1012-8. doi: 10.1021/jm5011176. Epub 2014 Dec 29.

PMID:
25427005
9.

Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines.

Giudice S, Benassi L, Bertazzoni G, Veratti E, Morini D, Azzoni P, Costi MP, Venturelli A, Pirondi S, Seidenari S, Magnoni C.

Invest New Drugs. 2012 Aug;30(4):1484-92. doi: 10.1007/s10637-011-9733-2. Epub 2011 Sep 1.

PMID:
21881917
10.

Permeation through the cell membrane of a boron-based β-lactamase inhibitor.

Minozzi M, Lattanzi G, Benz R, Costi MP, Venturelli A, Carloni P.

PLoS One. 2011;6(8):e23187. doi: 10.1371/journal.pone.0023187. Epub 2011 Aug 17.

11.

Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs.

Garg D, Henrich S, Salo-Ahen OM, Myllykallio H, Costi MP, Wade RC.

J Med Chem. 2010 Sep 23;53(18):6539-49. doi: 10.1021/jm901869w. Review. No abstract available.

PMID:
20527892
12.

Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines.

Marverti G, Ligabue A, Guerrieri D, Paglietti G, Piras S, Costi MP, Farina D, Frassineti C, Monti MG, Moruzzi MS.

Gynecol Oncol. 2010 May;117(2):202-10. doi: 10.1016/j.ygyno.2009.11.030. Epub 2010 Jan 19.

PMID:
20031193

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