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Toxins (Basel). 2016 Jul 6;8(7). pii: E208. doi: 10.3390/toxins8070208.

How Safe Is Safe for Marine Toxins Monitoring?

Author information

1
Departamento de Farmacología, Facultad Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain. luis.botana@usc.es.
2
Departamento de Farmacología, Facultad Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain. amparo.alfonso@usc.es.
3
Departamento de Farmacología, Facultad Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain. ines.rodriguez@usc.es.
4
Facultad de Ciencias, Universidad de Santiago, 27002 Lugo, Spain. anamaria.botana@usc.es.
5
Departamento de Farmacología, Facultad Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain. mcarmen.louzao@usc.es.
6
Departamento de Fisiología, Facultad Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain. mmercedes.rodriguez@usc.es.

Abstract

Current regulation for marine toxins requires a monitoring method based on mass spectrometric analysis. This method is pre-targeted, hence after searching for pre-assigned masses, it identifies those compounds that were pre-defined with available calibrants. Therefore, the scope for detecting novel toxins which are not included in the monitoring protocol are very limited. In addition to this, there is a poor comprehension of the toxicity of some marine toxin groups. Also, the validity of the current approach is questioned by the lack of sufficient calibrants, and by the insufficient coverage by current legislation of the toxins reported to be present in shellfish. As an example, tetrodotoxin, palytoxin analogs, or cyclic imines are mentioned as indicators of gaps in the system that require a solid comprehension to assure consumers are protected.

KEYWORDS:

food safety; marine toxin; mass spectrometry; monitoring; toxicity equivalency factor

PMID:
27399774
PMCID:
PMC4963841
DOI:
10.3390/toxins8070208
[Indexed for MEDLINE]
Free PMC Article

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