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Items: 1 to 20 of 38

1.

Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation.

Ortíz C, Botti H, Buschiazzo A, Comini MA.

J Mol Biol. 2019 Mar 28. pii: S0022-2836(18)30691-0. doi: 10.1016/j.jmb.2019.03.023. [Epub ahead of print]

PMID:
30930048
2.

Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites.

Manta B, Möller MN, Bonilla M, Deambrosi M, Grunberg K, Bellanda M, Comini MA, Ferrer-Sueta G.

J Biol Chem. 2019 Mar 1;294(9):3235-3248. doi: 10.1074/jbc.RA118.006366. Epub 2018 Dec 28.

PMID:
30593501
3.

Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi.

Mesías AC, Sasoni N, Arias DG, Pérez Brandán C, Orban OCF, Kunick C, Robello C, Comini MA, Garg NJ, Zago MP.

Free Radic Biol Med. 2019 Jan;130:23-34. doi: 10.1016/j.freeradbiomed.2018.10.436. Epub 2018 Oct 23.

PMID:
30359758
4.

The thiol-polyamine metabolism of Trypanosoma cruzi: molecular targets and drug repurposing strategies.

Talevi A, Carrillo C, Comini MA.

Curr Med Chem. 2018 Sep 26. doi: 10.2174/0929867325666180926151059. [Epub ahead of print]

PMID:
30259812
5.

The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region.

Sturlese M, Manta B, Bertarello A, Bonilla M, Lelli M, Zambelli B, Grunberg K, Mammi S, Comini MA, Bellanda M.

Sci Rep. 2018 Sep 12;8(1):13716. doi: 10.1038/s41598-018-31817-4.

6.

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes.

Ebersoll S, Musunda B, Schmenger T, Dirdjaja N, Bonilla M, Manta B, Ulrich K, Comini MA, Krauth-Siegel RL.

Redox Biol. 2018 May;15:532-547. doi: 10.1016/j.redox.2018.01.011. Epub 2018 Jan 31.

7.

Alternative Thiol-Based Redox Systems.

Salinas G, Comini MA.

Antioxid Redox Signal. 2018 Feb 20;28(6):407-409. doi: 10.1089/ars.2017.7464. Epub 2018 Jan 5.

PMID:
29207877
8.

Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions.

Manta B, Bonilla M, Fiestas L, Sturlese M, Salinas G, Bellanda M, Comini MA.

Antioxid Redox Signal. 2018 Feb 20;28(6):463-486. doi: 10.1089/ars.2017.7133. Epub 2017 Nov 27. Review.

PMID:
29048199
9.

Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes.

Franco J, Sardi F, Szilágyi L, Kövér KE, Fehér K, Comini MA.

Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):303-313. doi: 10.1016/j.ijpddr.2017.08.001. Epub 2017 Aug 12.

10.

Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony.

Fonseca MS, Comini MA, Resende BV, Santi AM, Zoboli AP, Moreira DS, Murta SM.

Exp Parasitol. 2017 Apr;175:36-43. doi: 10.1016/j.exppara.2017.02.001. Epub 2017 Feb 3.

PMID:
28167207
11.

In vitro activity and mode of action of distamycin analogues against African trypanosomes.

Franco J, Medeiros A, Benítez D, Perelmuter K, Serra G, Comini MA, Scarone L.

Eur J Med Chem. 2017 Jan 27;126:776-788. doi: 10.1016/j.ejmech.2016.12.002. Epub 2016 Dec 2.

PMID:
27951486
12.

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms.

Orban OC, Korn RS, Benítez D, Medeiros A, Preu L, Loaëc N, Meijer L, Koch O, Comini MA, Kunick C.

Bioorg Med Chem. 2016 Aug 15;24(16):3790-800. doi: 10.1016/j.bmc.2016.06.023. Epub 2016 Jun 13.

PMID:
27349574
13.

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.

Benítez D, Medeiros A, Fiestas L, Panozzo-Zenere EA, Maiwald F, Prousis KC, Roussaki M, Calogeropoulou T, Detsi A, Jaeger T, Šarlauskas J, Peterlin Mašič L, Kunick C, Labadie GR, Flohé L, Comini MA.

PLoS Negl Trop Dis. 2016 Apr 12;10(4):e0004617. doi: 10.1371/journal.pntd.0004617. eCollection 2016 Apr.

14.

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi.

Ortiz C, Moraca F, Medeiros A, Botta M, Hamilton N, Comini MA.

Molecules. 2016 Mar 17;21(3):368. doi: 10.3390/molecules21030368.

15.

Selenoproteins of African trypanosomes are dispensable for parasite survival in a mammalian host.

Bonilla M, Krull E, Irigoín F, Salinas G, Comini MA.

Mol Biochem Parasitol. 2016 Mar-Apr;206(1-2):13-9. doi: 10.1016/j.molbiopara.2016.03.002. Epub 2016 Mar 11.

PMID:
26975431
16.

Glutaredoxin-deficiency confers bloodstream Trypanosoma brucei with improved thermotolerance.

Musunda B, Benítez D, Dirdjaja N, Comini MA, Krauth-Siegel RL.

Mol Biochem Parasitol. 2015 Dec;204(2):93-105. doi: 10.1016/j.molbiopara.2016.02.001. Epub 2016 Feb 6.

PMID:
26854591
17.

Measurement and meaning of cellular thiol:disufhide redox status.

Comini MA.

Free Radic Res. 2016;50(2):246-71. doi: 10.3109/10715762.2015.1110241. Review.

PMID:
26695718
18.

A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters.

Bisio H, Bonilla M, Manta B, Graña M, Salzman V, Aguilar PS, Gladyshev VN, Comini MA, Salinas G.

Antioxid Redox Signal. 2016 Jan 27;24(4):205-216. Epub 2015 Oct 27.

PMID:
26381228
19.

Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands.

Miserachs HG, Cipriani M, Grau J, Vilaseca M, Lorenzo J, Medeiros A, Comini MA, Gambino D, Otero L, Moreno V.

J Inorg Biochem. 2015 Sep;150:38-47. doi: 10.1016/j.jinorgbio.2015.06.007. Epub 2015 Jun 9.

PMID:
26079954
20.

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.

Maiwald F, Benítez D, Charquero D, Dar MA, Erdmann H, Preu L, Koch O, Hölscher C, Loaëc N, Meijer L, Comini MA, Kunick C.

Eur J Med Chem. 2014 Aug 18;83:274-83. doi: 10.1016/j.ejmech.2014.06.020. Epub 2014 Jun 11.

PMID:
24973661

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