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Mater Sci Eng C Mater Biol Appl. 2015 Nov 1;56:286-93. doi: 10.1016/j.msec.2015.05.025. Epub 2015 May 9.

Microwave assisted synthesis and characterization of magnesium substituted calcium phosphate bioceramics.

Author information

1
Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, M. A. Jinnah Campus, Defence Road, Off Raiwind Road, Lahore, Pakistan; Medical Implant Technology Group (MEDITEG), Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor Darul Takzim, Malaysia.
2
Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, M. A. Jinnah Campus, Defence Road, Off Raiwind Road, Lahore, Pakistan.
3
Medical Implant Technology Group (MEDITEG), Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor Darul Takzim, Malaysia.
4
Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai, Johore, Malaysia.
5
Department of Physics, COMSATS Institute of Information Technology, Chakshahzad Campus, Islamabad, Pakistan.
6
Clean Materials Technology Group, Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H 0AJ, UK.
7
The Kroto Research Institute, North Campus, University of Sheffield, Broad Lane, Sheffield S3 7HQ, UK.
8
Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, M. A. Jinnah Campus, Defence Road, Off Raiwind Road, Lahore, Pakistan. Electronic address: aqifanwar@ciitlahore.edu.pk.

Abstract

Hydroxyapatite is used extensively in hard tissue repair due to its biocompatibility and similarity to biological apatite, the mineral component of bone. It differs subtly in composition from biological apatite which contains other ions such as magnesium, zinc, carbonate and silicon (believed to play biological roles). Traditional methods of hydroxyapatite synthesis are time consuming and require strict reaction parameter control. This paper outlines synthesis of magnesium substituted hydroxyapatite using simple microwave irradiation of precipitated suspensions. Microwave irradiation resulted in a drastic decrease in ageing times of amorphous apatitic phases. Time taken to synthesize hydroxyapatite (which remained stable upon heat treatment at 900°C for 1h) reduced twelve folds (to 2h) as compared to traditionally required times. The effects of increasing magnesium concentration in the precursors on particle size, surface area, phase-purity, agglomeration and thermal stability, were observed using scanning electron microscopy, BET surface area analysis, X-ray diffraction and photo acoustic Fourier transform infra-red spectroscopy. Porous agglomerates were obtained after a brief heat-treatment (1h) at 900°C.

KEYWORDS:

Bioceramics; Calcium phosphates; Magnesium substitution; Microwave synthesis

PMID:
26249592
DOI:
10.1016/j.msec.2015.05.025
[Indexed for MEDLINE]

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