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Items: 1 to 20 of 36


Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis.

Mota AH, Direito R, Carrasco MP, Rijo P, Ascensão L, Viana AS, Rocha J, Eduardo-Figueira M, Rodrigues MJ, Custódio L, Kuplennik N, Sosnik A, Almeida AJ, Gaspar MM, Reis CP.

Int J Pharm. 2019 Mar 25;559:13-22. doi: 10.1016/j.ijpharm.2019.01.017. Epub 2019 Jan 18.


Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies.

Trampetti F, Pereira C, Rodrigues MJ, Celaj O, D'Abrosca B, Zengin G, Mollica A, Stefanucci A, Custódio L.

J Pharm Biomed Anal. 2019 Feb 20;165:119-128. doi: 10.1016/j.jpba.2018.11.053. Epub 2018 Nov 24.


Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from Turkey.

Zengin G, Rodrigues MJ, Abdallah HH, Custodio L, Stefanucci A, Aumeeruddy MZ, Mollica A, Rengasamy KRR, Mahomoodally MF.

Comput Biol Chem. 2018 Dec;77:178-186. doi: 10.1016/j.compbiolchem.2018.10.005. Epub 2018 Oct 9.


Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles.

Zengin G, Stefanucci A, Rodrigues MJ, Mollica A, Custodio L, Aumeeruddy MZ, Mahomoodally MF.

J Pharm Biomed Anal. 2019 Jan 5;162:225-233. doi: 10.1016/j.jpba.2018.09.035. Epub 2018 Sep 18.


In vitro and in silico approaches to unveil the mechanisms underlying the cytotoxic effect of juncunol on human hepatocarcinoma cells.

Rodrigues MJ, Vizetto-Duarte C, Gangadhar KN, Zengin G, Mollica A, Varela J, Barreira L, Custódio L.

Pharmacol Rep. 2018 Oct;70(5):896-899. doi: 10.1016/j.pharep.2018.02.001. Epub 2018 Feb 2.


Antitubercular and anti-inflammatory properties screening of natural products from Plectranthus species.

Andrade JM, Custódio L, Romagnoli A, Reis CP, Rodrigues MJ, Garcia C, Petruccioli E, Goletti D, Faustino C, Fimia GM, Rijo P.

Future Med Chem. 2018 Jul 1;10(14):1677-1691. doi: 10.4155/fmc-2018-0043. Epub 2018 Jun 29.


Health promoting potential of herbal teas and tinctures from Artemisia campestris subsp. maritima: from traditional remedies to prospective products.

Pereira CG, Barreira L, Bijttebier S, Pieters L, Marques C, Santos TF, Rodrigues MJ, Varela J, Custódio L.

Sci Rep. 2018 Mar 16;8(1):4689. doi: 10.1038/s41598-018-23038-6.


Report of in vitro antileishmanial properties of Iberian macroalgae.

Bruno de Sousa C, Lago JHG, Macridachis J, Oliveira M, Brito L, Vizetto-Duarte C, Florindo C, Hendrickx S, Maes L, Morais T, Uemi M, Neto L, Dionísio L, Cortes S, Barreira L, Custódio L, Alberício F, Campino L, Varela J.

Nat Prod Res. 2018 Feb 9:1-5. doi: 10.1080/14786419.2018.1434637. [Epub ahead of print]


Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.

Uysal S, Ugurlu A, Zengin G, Baloglu MC, Altunoglu YC, Mollica A, Custodio L, Neng NR, Nogueira JMF, Mahomoodally MF.

Food Chem Toxicol. 2018 Jan;111:525-536. doi: 10.1016/j.fct.2017.11.058. Epub 2017 Dec 5.


Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea (Camellia sinensis) and rooibos tisane (Aspalathus linearis).

Pereira CG, Barreira L, Bijttebier S, Pieters L, Neves V, Rodrigues MJ, Rivas R, Varela J, Custódio L.

J Pharm Biomed Anal. 2017 Oct 25;145:593-603. doi: 10.1016/j.jpba.2017.07.007. Epub 2017 Jul 18.


A first glance into the nutritional properties of the sea cucumber Parastichopus regalis from the Mediterranean Sea (SE Spain).

Roggatz CC, González-Wangüemert M, Pereira H, Vizetto-Duarte C, Rodrigues MJ, Barreira L, da Silva MM, Varela J, Custódio L.

Nat Prod Res. 2018 Jan;32(1):116-120. doi: 10.1080/14786419.2017.1331224. Epub 2017 May 19.


First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast.

Oliveira M, João Rodrigues M, Pereira C, Neto RLDM, Junior PAS, Neng NDR, Nogueira JMF, Varela J, Barreira L, Custódio L.

Nat Prod Res. 2018 Mar;32(5):600-604. doi: 10.1080/14786419.2017.1326489. Epub 2017 May 11.


Searching for new sources of innovative products for the food industry within halophyte aromatic plants: In vitro antioxidant activity and phenolic and mineral contents of infusions and decoctions of Crithmum maritimum L.

Pereira CG, Barreira L, da Rosa Neng N, Nogueira JMF, Marques C, Santos TF, Varela J, Custódio L.

Food Chem Toxicol. 2017 Sep;107(Pt B):581-589. doi: 10.1016/j.fct.2017.04.018. Epub 2017 Apr 18.


Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies.

Rodrigues MJ, Gangadhar KN, Zengin G, Mollica A, Varela J, Barreira L, Custódio L.

Food Chem Toxicol. 2017 Sep;107(Pt B):590-596. doi: 10.1016/j.fct.2017.04.006. Epub 2017 Apr 8.


Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum.

Rodrigues MJ, Custódio L, Lopes A, Oliveira M, Neng NR, Nogueira JM, Martins A, Rauter AP, Varela J, Barreira L.

Pharm Biol. 2017 Dec;55(1):1348-1357. doi: 10.1080/13880209.2017.1301493.


Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata.

Bruno de Sousa C, Gangadhar KN, Morais TR, Conserva GA, Vizetto-Duarte C, Pereira H, Laurenti MD, Campino L, Levy D, Uemi M, Barreira L, Custódio L, Passero LF, Lago JH, Varela J.

Exp Parasitol. 2017 Mar;174:1-9. doi: 10.1016/j.exppara.2017.01.002. Epub 2017 Jan 24.


Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations.

Zengin G, Uysal A, Aktumsek A, Mocan A, Mollica A, Locatelli M, Custodio L, Neng NR, Nogueira JMF, Aumeeruddy-Elalfi Z, Mahomoodally MF.

Biomed Pharmacother. 2017 Mar;87:27-36. doi: 10.1016/j.biopha.2016.12.063. Epub 2016 Dec 29.


Isolation of a euryhaline microalgal strain, Tetraselmis sp. CTP4, as a robust feedstock for biodiesel production.

Pereira H, Gangadhar KN, Schulze PS, Santos T, de Sousa CB, Schueler LM, Custódio L, Malcata FX, Gouveia L, Varela JC, Barreira L.

Sci Rep. 2016 Oct 21;6:35663. doi: 10.1038/srep35663.


Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal.

Oliveira M, Sales Junior PA, Rodrigues MJ, DellaGreca M, Barreira L, Murta SM, Romanha AJ, Custódio L.

Asian Pac J Trop Med. 2016 Aug;9(8):735-41. doi: 10.1016/j.apjtm.2016.06.015. Epub 2016 Jun 29.


Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage.

Vizetto-Duarte C, Custódio L, Gangadhar KN, Lago JH, Dias C, Matos AM, Neng N, Nogueira JM, Barreira L, Albericio F, Rauter AP, Varela J.

Phytomedicine. 2016 May 15;23(5):550-7. doi: 10.1016/j.phymed.2016.02.008. Epub 2016 Feb 26.


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