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Items: 1 to 20 of 26

1.

Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain.

Vicario N, Pasquinucci L, Spitale FM, Chiechio S, Turnaturi R, Caraci F, Tibullo D, Avola R, Gulino R, Parenti R, Parenti C.

Mol Neurobiol. 2019 Apr 28. doi: 10.1007/s12035-019-1607-1. [Epub ahead of print]

PMID:
31030416
2.

Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells.

Zappalà A, Vicario N, Calabrese G, Turnaturi R, Pasquinucci L, Montenegro L, Spadaro A, Parenti R, Parenti C.

Nat Prod Res. 2019 Apr 2:1-7. doi: 10.1080/14786419.2019.1587428. [Epub ahead of print]

PMID:
30938188
3.

(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist.

Pasquinucci L, Turnaturi R, Calò G, Pappalardo F, Ferrari F, Russo G, Arena E, Montenegro L, Chiechio S, Prezzavento O, Parenti C.

Eur J Med Chem. 2019 Apr 15;168:189-198. doi: 10.1016/j.ejmech.2019.02.043. Epub 2019 Feb 18.

PMID:
30822708
4.

Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation.

Pasquinucci L, Turnaturi R, Montenegro L, Caraci F, Chiechio S, Parenti C.

Eur J Pharmacol. 2019 Mar 15;847:97-102. doi: 10.1016/j.ejphar.2019.01.031. Epub 2019 Jan 25.

PMID:
30690004
5.

Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review.

Turnaturi R, Montenegro L, Marrazzo A, Parenti R, Pasquinucci L, Parenti C.

Eur J Med Chem. 2018 Jul 15;155:492-502. doi: 10.1016/j.ejmech.2018.06.017. Epub 2018 Jun 7. Review.

PMID:
29908442
6.

Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives.

Pasquinucci L, Parenti C, Amata E, Georgoussi Z, Pallaki P, Camarda V, Calò G, Arena E, Montenegro L, Turnaturi R.

Pharmaceuticals (Basel). 2018 May 5;11(2). pii: E40. doi: 10.3390/ph11020040.

7.

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists.

Turnaturi R, Parenti C, Prezzavento O, Marrazzo A, Pallaki P, Georgoussi Z, Amata E, Pasquinucci L.

Molecules. 2018 Mar 16;23(3). pii: E677. doi: 10.3390/molecules23030677.

8.

In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations.

Montenegro L, Turnaturi R, Parenti C, Pasquinucci L.

Pharmaceutics. 2018 Feb 27;10(1). pii: E27. doi: 10.3390/pharmaceutics10010027.

9.

Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review.

Turnaturi R, Marrazzo A, Parenti C, Pasquinucci L.

Eur J Med Chem. 2018 Mar 25;148:410-422. doi: 10.1016/j.ejmech.2018.02.046. Epub 2018 Feb 17. Review.

PMID:
29477074
10.

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy.

Montenegro L, Turnaturi R, Parenti C, Pasquinucci L.

Nanomaterials (Basel). 2018 Feb 5;8(2). pii: E87. doi: 10.3390/nano8020087. Review.

11.

Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.

Montenegro L, Parenti C, Turnaturi R, Pasquinucci L.

Pharmaceutics. 2017 Dec 10;9(4). pii: E58. doi: 10.3390/pharmaceutics9040058.

12.

Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles.

Montenegro L, Pasquinucci L, Zappalà A, Chiechio S, Turnaturi R, Parenti C.

Pharmaceutics. 2017 Oct 21;9(4). pii: E48. doi: 10.3390/pharmaceutics9040048.

13.

Development of novel LP1-based analogues with enhanced delta opioid receptor profile.

Pasquinucci L, Turnaturi R, Prezzavento O, Arena E, Aricò G, Georgoussi Z, Parenti R, Cantarella G, Parenti C.

Bioorg Med Chem. 2017 Sep 1;25(17):4745-4752. doi: 10.1016/j.bmc.2017.07.021. Epub 2017 Jul 11.

PMID:
28734666
14.

Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management.

Turnaturi R, Arico G, Ronsisvalle G, Pasquinucci L, Parenti C.

Curr Med Chem. 2016;23(40):4506-4528. Review.

PMID:
27781944
15.

An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain.

Ronsisvalle S, Aricò G, Panarello F, Spadaro A, Pasquinucci L, Pappalardo MS, Parenti C, Ronsisvalle N.

Bioorg Med Chem. 2016 Nov 1;24(21):5280-5290. doi: 10.1016/j.bmc.2016.08.057. Epub 2016 Aug 30.

PMID:
27624520
16.

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation.

Arena E, Cacciatore I, Cerasa LS, Turkez H, Pittalà V, Pasquinucci L, Marrazzo A, Parenti C, Di Stefano A, Prezzavento O.

Bioorg Med Chem. 2016 Jul 15;24(14):3149-56. doi: 10.1016/j.bmc.2016.05.045. Epub 2016 May 21.

PMID:
27262426
17.

Evaluation of N-substituent structural variations in opioid receptor profile of LP1.

Pasquinucci L, Turnaturi R, Aricò G, Parenti C, Pallaki P, Georgoussi Z, Ronsisvalle S.

Bioorg Med Chem. 2016 Jun 15;24(12):2832-42. doi: 10.1016/j.bmc.2016.05.005. Epub 2016 May 5.

PMID:
27234885
18.

Multitarget opioid ligands in pain relief: New players in an old game.

Turnaturi R, Aricò G, Ronsisvalle G, Parenti C, Pasquinucci L.

Eur J Med Chem. 2016 Jan 27;108:211-228. doi: 10.1016/j.ejmech.2015.11.028. Epub 2015 Nov 22. Review.

PMID:
26656913
19.

Differential scanning calorimetry approach to investigate the transfer of the multitarget opioid analgesic LP1 to biomembrane model.

Accolla ML, Turnaturi R, Sarpietro MG, Ronsisvalle S, Castelli F, Pasquinucci L.

Eur J Med Chem. 2014 Apr 22;77:84-90. doi: 10.1016/j.ejmech.2014.02.056. Epub 2014 Feb 25.

PMID:
24631726
20.

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.

Parenti C, Marrazzo A, Aricò G, Parenti R, Pasquinucci L, Ronsisvalle S, Ronsisvalle G, Scoto GM.

Inflamm Res. 2014 Mar;63(3):231-7. doi: 10.1007/s00011-013-0692-2. Epub 2013 Dec 8.

PMID:
24316864

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