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Items: 1 to 20 of 30

1.

In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial.

Basilico N, Parapini S, Sparatore A, Romeo S, Misiano P, Vivas L, Yardley V, Croft SL, Habluetzel A, Lucantoni L, Renia L, Russell B, Suwanarusk R, Nosten F, Dondio G, Bigogno C, Jabes D, Taramelli D.

Molecules. 2017 Dec 1;22(12). pii: E2102. doi: 10.3390/molecules22122102.

2.

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.

Amewu RK, Chadwick J, Hussain A, Panda S, Rinki R, Janneh O, Ward SA, Miguel C, Burrell-Saward H, Vivas L, O'Neill PM.

Bioorg Med Chem. 2013 Dec 1;21(23):7392-7. doi: 10.1016/j.bmc.2013.09.047. Epub 2013 Oct 1.

PMID:
24148834
3.

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.

Lauinger IL, Vivas L, Perozzo R, Stairiker C, Tarun A, Zloh M, Zhang X, Xu H, Tonge PJ, Franzblau SG, Pham DH, Esguerra CV, Crawford AD, Maes L, Tasdemir D.

J Nat Prod. 2013 Jun 28;76(6):1064-70. doi: 10.1021/np400083k. Epub 2013 Jun 19.

4.

Hepatitis B Co-Infection is Associated with Poorer Survival of HIV-Infected Patients on Highly Active Antiretroviral Therapy in West Africa.

Ladep NG, Agbaji OO, Agaba PA, Muazu A, Ugoagwu P, Imade G, Cooke GS, Vivas L, Cormack SM, Taylor-Robinson SD, Idoko J, Kanki P.

J AIDS Clin Res. 2013 Jun 29;Suppl 3. pii: 006.

5.

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.

Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E, Thongphanchang C, Taweechai S, Vanichtanankul J, Rattanajak R, Arwon U, Fantauzzi P, Yuvaniyama J, Charman WN, Matthews D.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. doi: 10.1073/pnas.1204556109. Epub 2012 Oct 3.

6.

Curcumin enhances non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages.

Mimche PN, Thompson E, Taramelli D, Vivas L.

J Antimicrob Chemother. 2012 Aug;67(8):1895-904. doi: 10.1093/jac/dks132. Epub 2012 Apr 17.

PMID:
22511637
7.

Indolone-N-oxide derivatives: in vitro activity against fresh clinical isolates of Plasmodium falciparum, stage specificity and in vitro interactions with established antimalarial drugs.

Tahar R, Vivas L, Basco L, Thompson E, Ibrahim H, Boyer J, Nepveu F.

J Antimicrob Chemother. 2011 Nov;66(11):2566-72. doi: 10.1093/jac/dkr320. Epub 2011 Aug 22.

PMID:
21862474
8.

Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives.

Singh P, Sachdeva S, Raj R, Kumar V, Mahajan MP, Nasser S, Vivas L, Gut J, Rosenthal PJ, Feng TS, Chibale K.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4561-3. doi: 10.1016/j.bmcl.2011.05.119. Epub 2011 Jun 12.

PMID:
21705220
9.

The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria.

Mimche PN, Taramelli D, Vivas L.

Malar J. 2011 Mar 15;10 Suppl 1:S10. doi: 10.1186/1475-2875-10-S1-S10. Review.

10.

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

O'Neill PM, Amewu RK, Nixon GL, Bousejra ElGarah F, Mungthin M, Chadwick J, Shone AE, Vivas L, Lander H, Barton V, Muangnoicharoen S, Bray PG, Davies J, Park BK, Wittlin S, Brun R, Preschel M, Zhang K, Ward SA.

Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5693-7. doi: 10.1002/anie.201001026. No abstract available.

PMID:
20629058
11.

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.

Amewu R, Gibbons P, Mukhtar A, Stachulski AV, Ward SA, Hall C, Rimmer K, Davies J, Vivas L, Bacsa J, Mercer AE, Nixon G, Stocks PA, O'Neill PM.

Org Biomol Chem. 2010 May 7;8(9):2068-77. doi: 10.1039/b924319d. Epub 2010 Mar 3.

PMID:
20401383
12.

Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.

Nepveu F, Kim S, Boyer J, Chatriant O, Ibrahim H, Reybier K, Monje MC, Chevalley S, Perio P, Lajoie BH, Bouajila J, Deharo E, Sauvain M, Tahar R, Basco L, Pantaleo A, Turini F, Arese P, Valentin A, Thompson E, Vivas L, Petit S, Nallet JP.

J Med Chem. 2010 Jan 28;53(2):699-714. doi: 10.1021/jm901300d.

PMID:
20014857
13.

Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.

Pacorel B, Leung SC, Stachulski AV, Davies J, Vivas L, Lander H, Ward SA, Kaiser M, Brun R, O'Neill PM.

J Med Chem. 2010 Jan 28;53(2):633-40. doi: 10.1021/jm901216v.

PMID:
19957999
14.

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA.

J Med Chem. 2009 Apr 9;52(7):1828-44. doi: 10.1021/jm8012757.

15.

Antioxidant C-glucosylxanthones from the leaves of Arrabidaea patellifera.

Martin F, Hay AE, Cressend D, Reist M, Vivas L, Gupta MP, Carrupt PA, Hostettmann K.

J Nat Prod. 2008 Nov;71(11):1887-90. doi: 10.1021/np800406q. Epub 2008 Oct 25.

PMID:
18950229
16.

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM.

J Med Chem. 2008 Apr 10;51(7):2170-7. doi: 10.1021/jm701435h. Epub 2008 Mar 15.

PMID:
18341274
17.

Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo.

Vivas L, Rattray L, Stewart L, Bongard E, Robinson BL, Peters W, Croft SL.

Acta Trop. 2008 Mar;105(3):222-8. doi: 10.1016/j.actatropica.2007.12.005. Epub 2007 Dec 23.

PMID:
18279817
18.

Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives.

Vicente E, Charnaud S, Bongard E, Villar R, Burguete A, Solano B, Ancizu S, Pérez-Silanes S, Aldana I, Vivas L, Monge A.

Molecules. 2008 Jan 17;13(1):69-77.

19.

Hyperreactive malarial splenomegaly is associated with low levels of antibodies against red blood cell and Plasmodium falciparum derived glycolipids in Yanomami Amerindians from Venezuela.

Vivas L, O'Dea KP, Noya O, Pabon R, Magris M, Botto C, Holder AA, Brown KN.

Acta Trop. 2008 Mar;105(3):207-14. doi: 10.1016/j.actatropica.2007.12.007. Epub 2007 Dec 27.

PMID:
18243148
20.

Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents.

Vicente E, Lima LM, Bongard E, Charnaud S, Villar R, Solano B, Burguete A, Perez-Silanes S, Aldana I, Vivas L, Monge A.

Eur J Med Chem. 2008 Sep;43(9):1903-10. doi: 10.1016/j.ejmech.2007.11.024. Epub 2007 Dec 7.

PMID:
18215443

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