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Int J Environ Res Public Health. 2018 Jun 28;15(7). pii: E1358. doi: 10.3390/ijerph15071358.

A Physiologically-Based Pharmacokinetic Modeling Approach Using Biomonitoring Data in Order to Assess the Contribution of Drinking Water for the Achievement of an Optimal Fluoride Dose for Dental Health in Children.

Author information

1
Institut National de Santé Publique du Québec (INSPQ), Montréal, QC H2P 1E2, Canada. keven.biomed@outlook.com.
2
Département de Santé Environnementale et Santé au Travail, École de Santé Publique de l'Université de Montréal (ESPUM), Montréal, QC H3C 3J7, Canada. keven.biomed@outlook.com.
3
Institut National de Santé Publique du Québec (INSPQ), Montréal, QC H2P 1E2, Canada. nancy.wassef@inspq.qc.ca.
4
Institut National de Santé Publique du Québec (INSPQ), Montréal, QC H2P 1E2, Canada. fabien.gagnon@inspq.qc.ca.
5
Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, QC J1H 5N4, Canada. fabien.gagnon@inspq.qc.ca.
6
Institut National de Santé Publique du Québec (INSPQ), Montréal, QC H2P 1E2, Canada. mathieu.valcke@inspq.qc.ca.
7
Département de Santé Environnementale et Santé au Travail, École de Santé Publique de l'Université de Montréal (ESPUM), Montréal, QC H3C 3J7, Canada. mathieu.valcke@inspq.qc.ca.

Abstract

Due to an optimal fluoride concentration in drinking water advised for caries prevention purposes, the population is now exposed to multiple sources of fluoride. The availability of population biomonitoring data currently allow us to evaluate the magnitude of this exposure. The objective of this work was, therefore, to use such data in order to estimate whether community water fluoridation still represents a significant contribution toward achieving a suggested daily optimal fluoride (external) intake of 0.05 mg/kg/day. Therefore, a physiologically-based pharmacokinetic model for fluoride published in the literature was used and adapted in Excel for a typical 4-year-old and 8-year-old child. Biomonitoring data from the Canadian Health Measures Survey among people living in provinces with very different drinking water fluoridation coverage (Quebec, 2.5%; Ontario, 70% of the population) were analyzed using this adapted model. Absorbed doses for the 4-year-old and 8-year-old children were, respectively, 0.03 mg/kg/day and 0.02 mg/kg/day in Quebec and of 0.06 mg/kg/day and 0.05 mg/kg/day in Ontario. These results show that community water fluoridation contributes to increased fluoride intake among children, which leads to reaching, and in some cases even exceeding, the suggested optimal absorbed dose of 0.04 mg/kg/day, which corresponds to the suggested optimal fluoride intake mentioned above. In conclusion, this study constitutes an incentive to further explore the multiple sources of fluoride intake and suggests that a new balance between them including drinking water should be examined in accordance with the age-related physiological differences that influence fluoride metabolism.

KEYWORDS:

biomonitoring; dental health; drinking water; fluoride; pharmacokinetic modeling

PMID:
29958421
PMCID:
PMC6069276
DOI:
10.3390/ijerph15071358
[Indexed for MEDLINE]
Free PMC Article

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