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Angew Chem Int Ed Engl. 2019 Mar 18;58(12):4027-4030. doi: 10.1002/anie.201814088. Epub 2019 Feb 14.

Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach.

Author information

1
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
2
National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie, 510-0294, Japan.

Abstract

Flash chemistry based on flow microreactor systems allowed alkyllithiums bearing electrophilic functional groups to be successfully generated and used for subsequent reactions. The series of reactions with high reactivity was achieved by extremely accurate control over residence time in a controlled and selective manner.

KEYWORDS:

flow chemistry; lithium; microreactors; nucleophilic addition; synthetic methods

PMID:
30690827
DOI:
10.1002/anie.201814088

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