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Items: 7


Millisecond Timescale Motions Connect Amino Acid Interaction Networks in Alpha Tryptophan Synthase.

O'Rourke KF, Axe JM, D'Amico RN, Sahu D, Boehr DD.

Front Mol Biosci. 2018 Nov 8;5:92. doi: 10.3389/fmolb.2018.00092. eCollection 2018.


Assigning methyl resonances for protein solution-state NMR studies.

Gorman SD, Sahu D, O'Rourke KF, Boehr DD.

Methods. 2018 Sep 15;148:88-99. doi: 10.1016/j.ymeth.2018.06.010. Epub 2018 Jun 26.


Engineered control of enzyme structural dynamics and function.

Boehr DD, D'Amico RN, O'Rourke KF.

Protein Sci. 2018 Apr;27(4):825-838. doi: 10.1002/pro.3379. Epub 2018 Feb 16. Review.


Biophysical and computational methods to analyze amino acid interaction networks in proteins.

O'Rourke KF, Gorman SD, Boehr DD.

Comput Struct Biotechnol J. 2016 Jun 22;14:245-51. doi: 10.1016/j.csbj.2016.06.002. eCollection 2016. Review.


Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase.

Axe JM, O'Rourke KF, Kerstetter NE, Yezdimer EM, Chan YM, Chasin A, Boehr DD.

Protein Sci. 2015 Apr;24(4):484-94. doi: 10.1002/pro.2598. Epub 2014 Dec 11.


Amino acid networks in a (β/α)₈ barrel enzyme change during catalytic turnover.

Axe JM, Yezdimer EM, O'Rourke KF, Kerstetter NE, You W, Chang CE, Boehr DD.

J Am Chem Soc. 2014 May 14;136(19):6818-21. doi: 10.1021/ja501602t. Epub 2014 May 2.


Loop-loop interactions govern multiple steps in indole-3-glycerol phosphate synthase catalysis.

Zaccardi MJ, O'Rourke KF, Yezdimer EM, Loggia LJ, Woldt S, Boehr DD.

Protein Sci. 2014 Mar;23(3):302-11. doi: 10.1002/pro.2416. Epub 2014 Feb 4.

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