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A Novel Heterozygous Deletion Variant in KLOTHO Gene Leading to Haploinsufficiency and Impairment of Fibroblast Growth Factor 23 Signaling Pathway.

Martín-Núñez E, Donate-Correa J, Kannengiesser C, De Brauwere DP, Leroy C, Oudin C, Friedlander G, Prieto-Morín C, Tagua VG, Ureña-Torres PA, Navarro-González JF.

J Clin Med. 2019 Apr 12;8(4). pii: E500. doi: 10.3390/jcm8040500.


FGF23 and Klotho Levels are Independently Associated with Diabetic Foot Syndrome in Type 2 Diabetes Mellitus.

Donate-Correa J, Martín-Núñez E, Ferri C, Hernández-Carballo C, Tagua VG, Delgado-Molinos A, López-Castillo Á, Rodríguez-Ramos S, Cerro-López P, López-Tarruella VC, Arévalo-González MA, Pérez-Delgado N, Mora-Fernández C, Navarro-González JF.

J Clin Med. 2019 Apr 3;8(4). pii: E448. doi: 10.3390/jcm8040448.


Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons.

Donate-Correa J, Tagua VG, Ferri C, Martín-Núñez E, Hernández-Carballo C, Ureña-Torres P, Ruiz-Ortega M, Ortiz A, Mora-Fernández C, Navarro-González JF.

J Clin Med. 2019 Feb 27;8(3). pii: E287. doi: 10.3390/jcm8030287. Review.


Will the new molecules be effective in renal and cardiovascular protection in diabetes mellitus and diabetic kidney disease?

Martinez Martinez-Castelao A, Soler MJ, Navarro-González JF, Górriz JL.

Nefrologia. 2019 Jan - Feb;39(1):3-10. doi: 10.1016/j.nefro.2018.05.011. Epub 2018 Oct 2. English, Spanish. No abstract available.


Inflammation in Diabetic Kidney Disease.

Pérez-Morales RE, Del Pino MD, Valdivielso JM, Ortiz A, Mora-Fernández C, Navarro-González JF.

Nephron. 2018 Oct 1:1-5. doi: 10.1159/000493278. [Epub ahead of print] Review.


Association of the rs495392 Klotho polymorphism with atheromatosis progression in patients with chronic kidney disease.

Valdivielso JM, Bozic M, Galimudi RK, Bermudez-López M, Navarro-González JF, Fernández E, Betriu À; NEFRONA investigators.

Nephrol Dial Transplant. 2018 Jul 13. doi: 10.1093/ndt/gfy207. [Epub ahead of print]


Effects of Pentoxifylline on Soluble Klotho Concentrations and Renal Tubular Cell Expression in Diabetic Kidney Disease.

Navarro-González JF, Sánchez-Niño MD, Donate-Correa J, Martín-Núñez E, Ferri C, Pérez-Delgado N, Górriz JL, Martínez-Castelao A, Ortiz A, Mora-Fernández C.

Diabetes Care. 2018 Aug;41(8):1817-1820. doi: 10.2337/dc18-0078. Epub 2018 Jun 4.


Phenotypic Modulation of Cultured Primary Human Aortic Vascular Smooth Muscle Cells by Uremic Serum.

Cazaña-Pérez V, Cidad P, Donate-Correa J, Martín-Núñez E, López-López JR, Pérez-García MT, Giraldez T, Navarro-González JF, Alvarez de la Rosa D.

Front Physiol. 2018 Feb 12;9:89. doi: 10.3389/fphys.2018.00089. eCollection 2018.


Soluble levels and endogenous vascular gene expression of KLOTHO are related to inflammation in human atherosclerotic disease.

Martín-Núñez E, Donate-Correa J, López-Castillo Á, Delgado-Molinos A, Ferri C, Rodríguez-Ramos S, Cerro P, Pérez-Delgado N, Castro V, Hernández-Carballo C, Mora-Fernández C, Navarro-González JF.

Clin Sci (Lond). 2017 Oct 25;131(21):2601-2609. doi: 10.1042/CS20171242. Print 2017 Nov 1.


ERBP guideline on management of patients with diabetes and chronic kidney disease stage 3B or higher. Metformin for all?

Martínez-Castelao A, Górriz JL, Ortiz A, Navarro-González JF.

Nefrologia. 2017 Nov - Dec;37(6):567-571. doi: 10.1016/j.nefro.2017.06.001. Epub 2017 Jun 29. English, Spanish. No abstract available.


Anti-inflammatory profile of paricalcitol in kidney transplant recipients.

Donate-Correa J, Henríquez-Palop F, Martín-Núñez E, Hernández-Carballo C, Ferri C, Pérez-Delgado N, Muros-de-Fuentes M, Mora-Fernández C, Navarro-González JF.

Nefrologia. 2017 Nov - Dec;37(6):622-629. doi: 10.1016/j.nefro.2017.03.028. Epub 2017 Jun 15. English, Spanish.


Effect of Paricalcitol on FGF-23 and Klotho in Kidney Transplant Recipients.

Donate-Correa J, Henríquez-Palop F, Martín-Núñez E, Pérez-Delgado N, Muros-de-Fuentes M, Mora-Fernández C, Navarro-González JF.

Transplantation. 2016 Nov;100(11):2432-2438.


What is the optimal level of vitamin D in non-dialysis chronic kidney disease population?

Molina P, Górriz JL, Molina MD, Beltrán S, Vizcaíno B, Escudero V, Kanter J, Ávila AI, Bover J, Fernández E, Nieto J, Cigarrán S, Gruss E, Fernández-Juárez G, Martínez-Castelao A, Navarro-González JF, Romero R, Pallardó LM.

World J Nephrol. 2016 Sep 6;5(5):471-81. doi: 10.5527/wjn.v5.i5.471.


Implications of Fibroblast growth factor/Klotho system in glucose metabolism and diabetes.

Donate-Correa J, Martín-Núñez E, Delgado NP, de Fuentes MM, Arduan AO, Mora-Fernández C, Navarro González JF.

Cytokine Growth Factor Rev. 2016 Apr;28:71-7. doi: 10.1016/j.cytogfr.2015.12.003. Epub 2015 Dec 10. Review.


Predictors of Subclinical Atheromatosis Progression over 2 Years in Patients with Different Stages of CKD.

Gracia M, Betriu À, Martínez-Alonso M, Arroyo D, Abajo M, Fernández E, Valdivielso JM; NEFRONA Investigators.

Clin J Am Soc Nephrol. 2016 Feb 5;11(2):287-96. doi: 10.2215/CJN.01240215. Epub 2015 Dec 14.


Klotho in cardiovascular disease: Current and future perspectives.

Donate-Correa J, Martín-Núñez E, Mora-Fernández C, Muros-de-Fuentes M, Pérez-Delgado N, Navarro-González JF.

World J Biol Chem. 2015 Nov 26;6(4):351-7. doi: 10.4331/wjbc.v6.i4.351. Review.


Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease.

Donate-Correa J, Martín-Núñez E, Martínez-Sanz R, Muros-de-Fuentes M, Mora-Fernández C, Pérez-Delgado N, Navarro-González JF.

J Cell Mol Med. 2016 Jan;20(1):128-33. doi: 10.1111/jcmm.12710. Epub 2015 Nov 5.


Nephroprotection by Hypoglycemic Agents: Do We Have Supporting Data?

Górriz JL, Nieto J, Navarro-González JF, Molina P, Martínez-Castelao A, Pallardó LM.

J Clin Med. 2015 Oct 23;4(10):1866-89. doi: 10.3390/jcm4101866. Review.


Horizon 2020 in Diabetic Kidney Disease: The Clinical Trial Pipeline for Add-On Therapies on Top of Renin Angiotensin System Blockade.

Perez-Gomez MV, Sanchez-Niño MD, Sanz AB, Martín-Cleary C, Ruiz-Ortega M, Egido J, Navarro-González JF, Ortiz A, Fernandez-Fernandez B.

J Clin Med. 2015 Jun 18;4(6):1325-47. doi: 10.3390/jcm4061325. Review.


The Concept and the Epidemiology of Diabetic Nephropathy Have Changed in Recent Years.

Martínez-Castelao A, Navarro-González JF, Górriz JL, de Alvaro F.

J Clin Med. 2015 May 28;4(6):1207-16. doi: 10.3390/jcm4061207. Review.

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