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Items: 1 to 20 of 41


Clobetasol Modulates Adult Neural Stem Cell Growth via Canonical Hedgehog Pathway Activation.

Vicario N, Bernstock JD, Spitale FM, Giallongo C, Giunta MAS, Li Volti G, Gulisano M, Leanza G, Tibullo D, Parenti R, Gulino R.

Int J Mol Sci. 2019 Apr 23;20(8). pii: E1991. doi: 10.3390/ijms20081991.


SUMOylation in Glioblastoma: A Novel Therapeutic Target.

Fox BM, Janssen A, Estevez-Ordonez D, Gessler F, Vicario N, Chagoya G, Elsayed G, Sotoudeh H, Stetler W, Friedman GK, Bernstock JD.

Int J Mol Sci. 2019 Apr 15;20(8). pii: E1853. doi: 10.3390/ijms20081853. Review.


Roseamonas gilardii Bacteremia in a Patient With HbSβ0-thalassemia: Clinical Implications and Literature Review.

Schlappi C, Bernstock JD, Ricketts W, Nix GA, Poole C, Lebensburger J, Friedman GK.

J Pediatr Hematol Oncol. 2019 Apr 3. doi: 10.1097/MPH.0000000000001476. [Epub ahead of print]


Safety and efficacy of oncolytic HSV-1 G207 inoculated into the cerebellum of mice.

Bernstock JD, Vicario N, Li R, Nan L, Totsch SK, Schlappi C, Gessler F, Han X, Parenti R, Beierle EA, Whitley RJ, Aban I, Gillespie GY, Markert JM, Friedman GK.

Cancer Gene Ther. 2019 Mar 28. doi: 10.1038/s41417-019-0091-0. [Epub ahead of print]


SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke.

Bernstock JD, Peruzzotti-Jametti L, Leonardi T, Vicario N, Ye D, Lee YJ, Maric D, Johnson KR, Mou Y, Van Den Bosch A, Winterbone M, Friedman GK, Franklin RJM, Hallenbeck JM, Pluchino S.

EBioMedicine. 2019 Apr;42:214-224. doi: 10.1016/j.ebiom.2019.03.035. Epub 2019 Mar 21.


Stereotactic Placement of Intratumoral Catheters for Continuous Infusion Delivery of Herpes Simplex Virus -1 G207 in Pediatric Malignant Supratentorial Brain Tumors.

Bernstock JD, Wright Z, Bag AK, Gessler F, Gillespie GY, Markert JM, Friedman GK, Johnston JM.

World Neurosurg. 2019 Feb;122:e1592-e1598. doi: 10.1016/j.wneu.2018.11.122. Epub 2018 Nov 24.


Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression.

Friedman GK, Bernstock JD, Chen D, Nan L, Moore BP, Kelly VM, Youngblood SL, Langford CP, Han X, Ring EK, Beierle EA, Gillespie GY, Markert JM.

Sci Rep. 2018 Sep 17;8(1):13930. doi: 10.1038/s41598-018-32353-x.


The Impact of Early Corticosteroid Pretreatment Before Initiation of Chemotherapy in Patients With Primary Central Nervous System Lymphoma.

Gessler F, Bernstock JD, Behmanesh B, Brunnberg U, Harter P, Ye D, Friedman GK, Hansmann ML, Wagner M, Seifert V, Weise L, Marquardt G.

Neurosurgery. 2018 Jul 17. doi: 10.1093/neuros/nyy272. [Epub ahead of print]


Drugging SUMOylation for neuroprotection and oncotherapy.

Bernstock JD, Ye DG, Lee YJ, Gessler F, Friedman GK, Zheng W, Hallenbeck JM.

Neural Regen Res. 2018 Mar;13(3):415-416. doi: 10.4103/1673-5374.228718. No abstract available.


Surgery for Glioblastoma in Light of Molecular Markers: Impact of Resection and MGMT Promoter Methylation in Newly Diagnosed IDH-1 Wild-Type Glioblastomas.

Gessler F, Bernstock JD, Braczynski A, Lescher S, Baumgarten P, Harter PN, Mittelbronn M, Wu T, Seifert V, Senft C.

Neurosurgery. 2019 Jan 1;84(1):190-197. doi: 10.1093/neuros/nyy049.


Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.

Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok CK, Leonardi T, Booty LM, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Donegà M, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C, Pluchino S.

Cell Stem Cell. 2018 Mar 1;22(3):355-368.e13. doi: 10.1016/j.stem.2018.01.020. Epub 2018 Feb 22.


Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.

Karhausen J, Bernstock JD, Johnson KR, Sheng H, Ma Q, Shen Y, Yang W, Hallenbeck JM, Paschen W.

Lab Invest. 2018 Jun;98(6):799-813. doi: 10.1038/s41374-018-0035-6. Epub 2018 Feb 22.


Akt Protein Kinase, miR-200/miR-182 Expression and Epithelial-Mesenchymal Transition Proteins in Hibernating Ground Squirrels.

Lee YJ, Bernstock JD, Klimanis D, Hallenbeck JM.

Front Mol Neurosci. 2018 Jan 30;11:22. doi: 10.3389/fnmol.2018.00022. eCollection 2018.


Cerebral Ischemia Increases Small Ubiquitin-Like Modifier Conjugation within Human Penumbral Tissue: Radiological-Pathological Correlation.

Bernstock JD, Ye DG, Griffin A, Lee YJ, Lynch J, Latour LL, Friedman GK, Maric D, Hallenbeck JM.

Front Neurol. 2018 Jan 12;8:738. doi: 10.3389/fneur.2017.00738. eCollection 2017.


SUMOylation in brain ischemia: Patterns, targets, and translational implications.

Bernstock JD, Yang W, Ye DG, Shen Y, Pluchino S, Lee YJ, Hallenbeck JM, Paschen W.

J Cereb Blood Flow Metab. 2018 Jan;38(1):5-16. doi: 10.1177/0271678X17742260. Epub 2017 Nov 17. Review.


Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.

Bernstock JD, Ye D, Smith JA, Lee YJ, Gessler FA, Yasgar A, Kouznetsova J, Jadhav A, Wang Z, Pluchino S, Zheng W, Simeonov A, Hallenbeck JM, Yang W.

FASEB J. 2018 Mar;32(3):1677-1691. doi: 10.1096/fj.201700711R. Epub 2018 Jan 3.


Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.

Bernstock JD, Ye D, Gessler FA, Lee YJ, Peruzzotti-Jametti L, Baumgarten P, Johnson KR, Maric D, Yang W, Kögel D, Pluchino S, Hallenbeck JM.

Sci Rep. 2017 Aug 7;7(1):7425. doi: 10.1038/s41598-017-07631-9.


Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3.

Klover PJ, Thangapazham RL, Kato J, Wang JA, Anderson SA, Hoffmann V, Steagall WK, Li S, McCart E, Nathan N, Bernstock JD, Wilkerson MD, Dalgard CL, Moss J, Darling TN.

Elife. 2017 Jul 11;6. pii: e23202. doi: 10.7554/eLife.23202.


Extracellular vesicles are independent metabolic units with asparaginase activity.

Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S.

Nat Chem Biol. 2017 Sep;13(9):951-955. doi: 10.1038/nchembio.2422. Epub 2017 Jul 3.


Assessment of molecular markers demonstrates concordance between samples acquired via stereotactic biopsy and open craniotomy in both anaplastic astrocytomas and glioblastomas.

Gessler F, Baumgarten P, Bernstock JD, Harter P, Lescher S, Senft C, Seifert V, Marquardt G, Weise L.

J Neurooncol. 2017 Jun;133(2):399-407. doi: 10.1007/s11060-017-2448-2. Epub 2017 May 15.


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