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Items: 1 to 20 of 65

1.

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

Milton ME, Minrovic BM, Harris DL, Kang B, Jung D, Lewis CP, Thompson RJ, Melander RJ, Zeng D, Melander C, Cavanagh J.

Front Mol Biosci. 2018 Feb 13;5:15. doi: 10.3389/fmolb.2018.00015. eCollection 2018.

2.

The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism.

Draughn GL, Milton ME, Feldmann EA, Bobay BG, Roth BM, Olson AL, Thompson RJ, Actis LA, Davies C, Cavanagh J.

J Mol Biol. 2018 Mar 16;430(6):806-821. doi: 10.1016/j.jmb.2018.02.002. Epub 2018 Feb 10.

3.

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds.

Milton ME, Allen CL, Feldmann EA, Bobay BG, Jung DK, Stephens MD, Melander RJ, Theisen KE, Zeng D, Thompson RJ, Melander C, Cavanagh J.

Mol Microbiol. 2017 Oct;106(2):223-235. doi: 10.1111/mmi.13759. Epub 2017 Aug 16.

4.

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections.

Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J.

Drug Des Devel Ther. 2017 Jan 16;11:153-162. doi: 10.2147/DDDT.S111865. eCollection 2017.

5.

Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.

Stephens MD, Hubble VB, Ernst RK, van Hoek ML, Melander RJ, Cavanagh J, Melander C.

Medchemcomm. 2016 Jan 1;7(1):128-131. Epub 2015 Sep 30.

6.

Teaching old drugs new tricks: Addressing resistance in Francisella.

Feldmann EA, Cavanagh J.

Virulence. 2015;6(5):414-6. doi: 10.1080/21505594.2015.1053689. No abstract available.

7.

Augmenting anti-cancer natural products with a small molecule adjuvant.

Wahome PG, Beauchesne KR, Pedone AC, Cavanagh J, Melander C, Zimba P, Moeller PD.

Mar Drugs. 2014 Dec 26;13(1):65-75. doi: 10.3390/md13010065.

8.

Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii.

Stowe SD, Thompson RJ, Peng L, Su Z, Blackledge MS, Draughn GL, Coe WH, Johannes E, Lapham VK, Mackenzie J, Melander C, Cavanagh J.

Curr Drug Deliv. 2015;12(2):223-30.

9.

Structure and DNA-binding traits of the transition state regulator AbrB.

Olson AL, Tucker AT, Bobay BG, Soderblom EJ, Moseley MA, Thompson RJ, Cavanagh J.

Structure. 2014 Nov 4;22(11):1650-6. doi: 10.1016/j.str.2014.08.018. Epub 2014 Oct 9.

10.

Small-molecule suppression of β-lactam resistance in multidrug-resistant gram-negative pathogens.

Brackett CM, Melander RJ, An IH, Krishnamurthy A, Thompson RJ, Cavanagh J, Melander C.

J Med Chem. 2014 Sep 11;57(17):7450-8. doi: 10.1021/jm501050e. Epub 2014 Aug 28.

PMID:
25137478
11.

A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA.

Tucker AT, Bobay BG, Banse AV, Olson AL, Soderblom EJ, Moseley MA, Thompson RJ, Varney KM, Losick R, Cavanagh J.

J Mol Biol. 2014 May 1;426(9):1911-24. doi: 10.1016/j.jmb.2014.02.010. Epub 2014 Feb 15.

12.

Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum.

Bobay BG, Thompson RJ, Milton DL, Cavanagh J.

Biomol NMR Assign. 2014 Apr;8(1):177-9. doi: 10.1007/s12104-013-9478-2. Epub 2013 Apr 21.

13.

Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis.

Stowe SD, Olson AL, Losick R, Cavanagh J.

Biomol NMR Assign. 2014 Apr;8(1):155-8. doi: 10.1007/s12104-013-9473-7. Epub 2013 Mar 10.

14.

Chemical crosslinking and LC/MS analysis to determine protein domain orientation: application to AbrB.

Olson AL, Liu F, Tucker AT, Goshe MB, Cavanagh J.

Biochem Biophys Res Commun. 2013 Feb 8;431(2):253-7. doi: 10.1016/j.bbrc.2012.12.124. Epub 2013 Jan 9.

15.

Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii.

Olson AL, Thompson RJ, Melander C, Cavanagh J.

Biomol NMR Assign. 2014 Apr;8(1):67-70. doi: 10.1007/s12104-012-9454-2. Epub 2012 Dec 21.

16.

Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent.

Thompson RJ, Bobay BG, Stowe SD, Olson AL, Peng L, Su Z, Actis LA, Melander C, Cavanagh J.

Biochemistry. 2012 Dec 11;51(49):9776-8. doi: 10.1021/bi3015289. Epub 2012 Nov 29.

17.

Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3.

Bobay BG, Stewart AL, Tucker AT, Thompson RJ, Varney KM, Cavanagh J.

FEBS Lett. 2012 Oct 19;586(20):3582-9. doi: 10.1016/j.febslet.2012.08.032. Epub 2012 Sep 13.

18.

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems.

Stowe SD, Tucker AT, Thompson R, Piper A, Richards JJ, Rogers SA, Mathies LD, Melander C, Cavanagh J.

Drug Chem Toxicol. 2012 Jul;35(3):310-5. doi: 10.3109/01480545.2011.614620. Epub 2012 Jan 31.

19.

Dynamics and activation in response regulators: the β4-α4 loop.

Bobay BG, Hoch JA, Cavanagh J.

Biomol Concepts. 2012 Feb 1;3(2):175-182.

20.

Intercepting bacterial indole signaling with flustramine derivatives.

Bunders CA, Minvielle MJ, Worthington RJ, Ortiz M, Cavanagh J, Melander C.

J Am Chem Soc. 2011 Dec 21;133(50):20160-3. doi: 10.1021/ja209836z. Epub 2011 Nov 22.

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