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Items: 1 to 20 of 54


Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator.

Vella A, Freeman JLR, Dunn I, Keller K, Buse JB, Valcarce C.

Sci Transl Med. 2019 Jan 16;11(475). pii: eaau3441. doi: 10.1126/scitranslmed.aau3441.


Microarray, IPA and GSEA Analysis in Mice Models.

Oprescu SN, Horzmann KA, Yue F, Freeman JL, Kuang S.

Bio Protoc. 2018 Sep 5;8(17). pii: e2999. doi: 10.21769/BioProtoc.2999.


Comparative Assessment of Tungsten Toxicity in the Absence or Presence of Other Metals.

Wasel O, Freeman JL.

Toxics. 2018 Nov 9;6(4). pii: E66. doi: 10.3390/toxics6040066. Review.


Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures.

Horzmann KA, Reidenbach LS, Thanki DH, Winchester AE, Qualizza BA, Ryan GA, Egan KE, Hedrick VE, Sobreira TJP, Peterson SM, Weber GJ, Wirbisky-Hershberger SE, Sepúlveda MS, Freeman JL.

J Proteomics. 2018 Aug 30;186:71-82. doi: 10.1016/j.jprot.2018.07.006. Epub 2018 Jul 20.


Embryonic exposure to an aqueous coal dust extract results in gene expression alterations associated with the development and function of connective tissue and the hematological system, immunological and inflammatory disease, and cancer in zebrafish.

Caballero-Gallardo K, Wirbisky-Hershberger SE, Olivero-Verbel J, de la Rosa J, Freeman JL.

Metallomics. 2018 Mar 1;10(3):463-473. doi: 10.1039/c7mt00300e. Epub 2018 Feb 27.


Making Waves: New Developments in Toxicology With the Zebrafish.

Horzmann KA, Freeman JL.

Toxicol Sci. 2018 May 1;163(1):5-12. doi: 10.1093/toxsci/kfy044. Review.


MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation.

Zhou W, Pal AS, Hsu AY, Gurol T, Zhu X, Wirbisky-Hershberger SE, Freeman JL, Kasinski AL, Deng Q.

Cell Rep. 2018 Feb 13;22(7):1810-1823. doi: 10.1016/j.celrep.2018.01.058.


An embryonic 100μg/L lead exposure results in sex-specific expression changes in genes associated with the neurological system in female or cancer in male adult zebrafish brains.

Lee J, Horzmann KA, Freeman JL.

Neurotoxicol Teratol. 2018 Jan - Feb;65:60-69. doi: 10.1016/ Epub 2017 Oct 24.


Comparative analytical and toxicological assessment of methylcyclohexanemethanol (MCHM) mixtures associated with the Elk River chemical spill.

Horzmann KA, de Perre C, Lee LS, Whelton AJ, Freeman JL.

Chemosphere. 2017 Dec;188:599-607. doi: 10.1016/j.chemosphere.2017.09.026. Epub 2017 Sep 6.


Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression.

Wirbisky-Hershberger SE, Sanchez OF, Horzmann KA, Thanki D, Yuan C, Freeman JL.

Food Chem Toxicol. 2017 Nov;109(Pt 1):727-734. doi: 10.1016/j.fct.2017.08.041. Epub 2017 Aug 30.


Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity.

Horzmann KA, Freeman JL.

Toxics. 2016 Sep;4(3). pii: 19. doi: 10.3390/toxics4030019. Epub 2016 Aug 27.


Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I.

Elsayed MSA, Su Y, Wang P, Sethi T, Agama K, Ravji A, Redon CE, Kiselev E, Horzmann KA, Freeman JL, Pommier Y, Cushman M.

J Med Chem. 2017 Jul 13;60(13):5364-5376. doi: 10.1021/acs.jmedchem.6b01870. Epub 2017 Jun 28.


Toxicogenomics to Evaluate Endocrine Disrupting Effects of Environmental Chemicals Using the Zebrafish Model.

Caballero-Gallardo K, Olivero-Verbel J, Freeman JL.

Curr Genomics. 2016 Dec;17(6):515-527. doi: 10.2174/1389202917666160513105959.


Atrazine exposure elicits copy number alterations in the zebrafish genome.

Wirbisky SE, Freeman JL.

Comp Biochem Physiol C Toxicol Pharmacol. 2017 Apr;194:1-8. doi: 10.1016/j.cbpc.2017.01.003. Epub 2017 Jan 19.


Lead (Pb) exposure reduces global DNA methylation level by non-competitive inhibition and alteration of dnmt expression.

Sanchez OF, Lee J, Yu King Hing N, Kim SE, Freeman JL, Yuan C.

Metallomics. 2017 Feb 22;9(2):149-160. doi: 10.1039/c6mt00198j.


Regulatory landscape and clinical implication of MBD3 in human malignant glioma.

Cui Y, Li J, Weng L, Wirbisky SE, Freeman JL, Liu J, Liu Q, Yuan X, Irudayaraj J.

Oncotarget. 2016 Dec 6;7(49):81698-81714. doi: 10.18632/oncotarget.13173.


Embryonic atrazine exposure alters zebrafish and human miRNAs associated with angiogenesis, cancer, and neurodevelopment.

Wirbisky SE, Weber GJ, Schlotman KE, Sepúlveda MS, Freeman JL.

Food Chem Toxicol. 2016 Dec;98(Pt A):25-33. doi: 10.1016/j.fct.2016.03.027. Epub 2016 Apr 1.


Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice.

Bi P, Yue F, Karki A, Castro B, Wirbisky SE, Wang C, Durkes A, Elzey BD, Andrisani OM, Bidwell CA, Freeman JL, Konieczny SF, Kuang S.

J Exp Med. 2016 Sep 19;213(10):2019-37. doi: 10.1084/jem.20160157. Epub 2016 Aug 29.


Embryonic Atrazine Exposure Elicits Alterations in Genes Associated with Neuroendocrine Function in Adult Male Zebrafish.

Wirbisky SE, Sepúlveda MS, Weber GJ, Jannasch AS, Horzmann KA, Freeman JL.

Toxicol Sci. 2016 Sep;153(1):149-64. doi: 10.1093/toxsci/kfw115. Epub 2016 Jul 13.

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