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Items: 1 to 20 of 30

1.

Structural basis for chemically-induced homodimerization of a single domain antibody.

Lesne J, Chang HJ, De Visch A, Paloni M, Barthe P, Guichou JF, Mayonove P, Barducci A, Labesse G, Bonnet J, Cohen-Gonsaud M.

Sci Rep. 2019 Feb 12;9(1):1840. doi: 10.1038/s41598-019-38752-y.

2.

Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis.

Guca E, Nagy GN, Hajdú F, Marton L, Izrael R, Hoh F, Yang Y, Vial H, Vértessy BG, Guichou JF, Cerdan R.

Sci Rep. 2018 Jul 25;8(1):11215. doi: 10.1038/s41598-018-29500-9.

3.

Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti-Flaviviridae Activity.

Nevers Q, Ruiz I, Ahnou N, Donati F, Brillet R, Softic L, Chazal M, Jouvenet N, Fourati S, Baudesson C, Bruscella P, Gelin M, Guichou JF, Pawlotsky JM, Ahmed-Belkacem A.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00126-18. doi: 10.1128/AAC.00126-18. Print 2018 Jul.

4.

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

Gibault F, Coevoet M, Sturbaut M, Farce A, Renault N, Allemand F, Guichou JF, Drucbert AS, Foulon C, Magnez R, Thuru X, Corvaisier M, Huet G, Chavatte P, Melnyk P, Bailly F, Cotelle P.

Cancers (Basel). 2018 May 8;10(5). pii: E140. doi: 10.3390/cancers10050140.

5.

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.

Ahmed-Belkacem A, Colliandre L, Ahnou N, Nevers Q, Gelin M, Bessin Y, Brillet R, Cala O, Douguet D, Bourguet W, Krimm I, Pawlotsky JM, Guichou JF.

Nat Commun. 2016 Sep 22;7:12777. doi: 10.1038/ncomms12777.

6.

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication.

Lahaye X, Satoh T, Gentili M, Cerboni S, Silvin A, Conrad C, Ahmed-Belkacem A, Rodriguez EC, Guichou JF, Bosquet N, Piel M, Le Grand R, King MC, Pawlotsky JM, Manel N.

Cell Rep. 2016 Apr 26;15(4):879-892. doi: 10.1016/j.celrep.2016.03.074. Epub 2016 Apr 14.

7.

New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.

Zghaib Z, Guichou JF, Vappiani J, Bec N, Hadj-Kaddour K, Vincent LA, Paniagua-Gayraud S, Larroque C, Moarbess G, Cuq P, Kassab I, Deleuze-Masquéfa C, Diab-Assaf M, Bonnet PA.

Bioorg Med Chem. 2016 Jun 1;24(11):2433-40. doi: 10.1016/j.bmc.2016.04.004. Epub 2016 Apr 1.

PMID:
27094151
8.

New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors.

Moarbess G, Guichou JF, Paniagua-Gayraud S, Chouchou A, Marcadet O, Leroy F, Ruédas R, Cuq P, Deleuze-Masquéfa C, Bonnet PA.

Eur J Med Chem. 2016 Jun 10;115:268-74. doi: 10.1016/j.ejmech.2016.03.006. Epub 2016 Mar 17.

PMID:
27017554
9.

Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study.

Kaplan E, Guichou JF, Chaloin L, Kunzelmann S, Leban N, Serpersu EH, Lionne C.

Biochim Biophys Acta. 2016 Apr;1860(4):802-13. doi: 10.1016/j.bbagen.2016.01.016. Epub 2016 Jan 21.

10.

Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.

Gelin M, Delfosse V, Allemand F, Hoh F, Sallaz-Damaz Y, Pirocchi M, Bourguet W, Ferrer JL, Labesse G, Guichou JF.

Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1777-87. doi: 10.1107/S1399004715010342. Epub 2015 Jul 31.

PMID:
26249358
11.

Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution.

Bianchin A, Allemand F, Bell A, Chubb AJ, Guichou JF.

Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1319-27. doi: 10.1107/S1399004715006239. Epub 2015 May 14.

PMID:
26057671
12.

Protein-ligand structure guided by backbone and side-chain proton chemical shift perturbations.

Aguirre C, ten Brink T, Cala O, Guichou JF, Krimm I.

J Biomol NMR. 2014 Nov;60(2-3):147-56. doi: 10.1007/s10858-014-9864-9. Epub 2014 Sep 26.

PMID:
25256941
13.

Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.

Sagnol S, Yang Y, Bessin Y, Allemand F, Hapkova I, Notarnicola C, Guichou JF, Faure S, Labesse G, de Santa Barbara P.

Nucleic Acids Res. 2014 Sep;42(15):10173-84. doi: 10.1093/nar/gku692. Epub 2014 Jul 26.

14.

Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention.

Ahmed-Belkacem A, Guichou JF, Brillet R, Ahnou N, Hernandez E, Pallier C, Pawlotsky JM.

Nucleic Acids Res. 2014 Aug;42(14):9399-409. doi: 10.1093/nar/gku632. Epub 2014 Jul 22.

15.

Comparing binding modes of analogous fragments using NMR in fragment-based drug design: application to PRDX5.

Aguirre C, ten Brink T, Guichou JF, Cala O, Krimm I.

PLoS One. 2014 Jul 15;9(7):e102300. doi: 10.1371/journal.pone.0102300. eCollection 2014.

16.

Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA.

Eldin P, Chazal N, Fenard D, Bernard E, Guichou JF, Briant L.

Nucleic Acids Res. 2014 Feb;42(3):1698-710. doi: 10.1093/nar/gkt974. Epub 2013 Oct 30.

17.

Fragment and conquer: from structure to complexes to function.

Guichou JF, Labesse G.

Structure. 2012 Oct 10;20(10):1617-9. doi: 10.1016/j.str.2012.09.008.

18.

e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design.

Pihan E, Colliandre L, Guichou JF, Douguet D.

Bioinformatics. 2012 Jun 1;28(11):1540-1. doi: 10.1093/bioinformatics/bts186. Epub 2012 Apr 26.

PMID:
22539672
19.

In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.

le Maire A, Gelin M, Pochet S, Hoh F, Pirocchi M, Guichou JF, Ferrer JL, Labesse G.

Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):747-55. doi: 10.1107/S0907444911023249. Epub 2011 Aug 9.

PMID:
21904027
20.

Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization.

Nahoum V, Lipski A, Quillard F, Guichou JF, Boublik Y, Pérez E, Germain P, de Lera AR, Bourguet W.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt 7):614-6. doi: 10.1107/S1744309108015492. Epub 2008 Jun 11.

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